Impact of anthocyanins and dietary carbohydrates on intestinal tumorigenesis in ApcMin/+ mice
Consumption of anthocyanins reduces the development of intestinal tumors in ApcMin/+ mice, whereas diets rich in sucrose increase intestinal tumor development. The aim of this study was to determine the efficacy of anthocyanins to reduce intestinal tumorigenesis in ApcMin/+ mice consuming diets rich in sucrose and other dietary carbohydrates. Mice were assigned to six different modified AIN-93G diets, which contained different carbohydrate sources (starch, sucrose, or glucose) and different doses of anthocyanins (0 or 1500 mg/kg) in a factorial design. To enhance tumor development, mice were injected for three consecutive weeks with azoxymethane (8 mg/kg) prior to dietary intervention. Mice consuming sucrose showed the largest colonic adenomas compared to mice consuming anthocyanin-sucrose, anthocyanin-glucose, glucose, and starch (P<0.05). These results demonstrate that anthocyanins and different carbohydrates influence intestinal adenoma development in ApcMin/+ mice; however, additional research is required to determine the mechanisms for the observed effects.
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- In Collections
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Electronic Theses & Dissertations
- Copyright Status
- In Copyright
- Material Type
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Theses
- Authors
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Walker, Ryan (Ryan Adam)
- Thesis Advisors
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Bourquin, Leslie D.
- Committee Members
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Nair, Muraleedharan
Fenton, Jenifer
- Date
- 2013
- Subjects
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Anthocyanins
Carbohydrates
Intestines--Tumors
- Program of Study
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Human Nutrition - Master of Science
- Degree Level
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Masters
- Language
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English
- Pages
- viii, 98 pages
- ISBN
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9781303065217
1303065215
- Permalink
- https://doi.org/doi:10.25335/pvj4-bg31