A coarse-grained model is used to simulate lipid bilayers (LB) interacting with nanoparticles (NP). Different equilibrium states are observed as the size of the NP is varied along with the interaction strength between the NP and LB. Sufficient attraction causes the NP to become wrapped by the LB. Large NP are able to form pores in the LB. These various outcomes are explained using a continuum theory.The same model is used to simulate pore healing in LB. It is observed that the area of the pore decreases linearly with time as explained by Allen-Cahn theory. Bulk properties of the LB can be used to predict the closing time of a pore as well as the amount of charge able to flow through the pore while it is open.
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