Campylobacter is a zoonotic agent and the leading cause of human gastroenteritis worldwide. An increasing trend for both campylobacteriosis incidence and antimicrobial resistance of Campylobacter, especially of C. jejuni, is reported globally. In the U.S., Center for Disease Control and Prevention (CDC) conducts surveillance systems in 10 sites to monitor the incidence and track the trends of antimicrobial resistance of Campylobacter, however, Michigan is not included in the system. This dissertation is dedicated to describe the epidemiology of campylobacteriosis in Michigan, and further characterize the antimicrobial resistance and genetic diversity using a subset of recovered human isolates. Furthermore, C. jejuni isolates from cattle were characterized for the genotypes and antimicrobial resistance, and compared with human isolates to elucidate the association, and possibly the transmission dynamics of C. jejuni between two species.
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