!!!!!"#$#%&'!($)!$*$+"#$#%&'!,('%*-.!(,,#'%&$"!./-0&0(1!*,!"1&*21(.%*3(!3/1%&,*-3#!4(%&#$%.!!25!!6789+:89!:89;!<7!!!!!!!!!!!!!!!!!!!!(!%:#.&.!!.7=>?@@AB!@C!3?DE?F89!.@8@A!/9?GAHI?@5!?9!J8H@?8K!L7KL?KK>A9@!CL!@EA!HAM7?HA>A9@I!LCH!@EA!BAFHAA!CL!!2?CI@8@?I@?DI!N!38I@AH!CL!.D?A9DA!!OPQR!!!!!"#$%&"'%!!"#$#%&'!($)!$*$+"#$#%&'!,('%*-.!(,,#'%&$"!./-0&0(1!*,!"1&*21(.%*3(!3/1%&,*-3#!4(%&#$%.!!25!!6789+:89!:89;!<7!!Glioblastoma Multiforme (GBM) is the most malignant and common primary brain tumor. Despite improvements in clinical treatment, the five-year survival rate is only 10%. In recent years, given the increased availability of omic data, the analysis of cancer datasets has seen a change in emphasis from non-genetic factors to understanding the genetic factors contributing to the disease. The goal of this study is to jointly model time to death of GBM patients with clinical and demographic covariates along with target SNP and GE. For this study we applied 2 datasets, The Cancer Genome Atlas (TCGA) and Surveillance, Epidemiology, and End Results (SEER). In concordance with previous studies, the non-genetic factors found to significantly affect survival included: age, race, area of residence in the US, treatment, Karnofsky performance score, number of primary tumors, and tumor location. Additionally, expression quantitative trait loci (eQTL) analysis was performed to assess the genetic regulation of gene expression. Finally, a gene expression wide association study (GE-WAS) was also performed to capture associations between survival and the whole genome gene expression. %SC!EC@IJC@!.$4!SAHA!?BA9@?L?AB!=5!AT%1!898K5I?IU!8KKAKA!V(W!?9!=C@E!EC@IJC@I!@A9BAB!@C!=A!8IICD?8@AB!S?@E!KC9FAH!I7HG?G8K!?9!=C@E!EC@IJC@IX!:CSAGAHY!@EAIA!EC@IJC@I!SAHA!9C@!I?F9?L?D89@K5!8IICD?8@AB!S?@E!I7HG?G8KX!,?98KK5Y!LC7H@AA9!FA9AI!SAHA!LC79B!@C!=A!I?F9?L?D89@K5!8IICD?8@AB!S?@E!I7HG?G8K!?9!"23!J8@?A9@I!8K@EC7FE!@E?I!I?F9?L?D89DA!B?I8JJA8HAB!8L@AH!DC9@HCKK?9F!LCH!BA>CFH8JE?D!DCG8H?8@AIX !!???!"'()*+,-./-0-)%$!!!&!SC7KB!K?;A!@C!AZJHAII!>5!FH8@?@7BA!@C!8KK!@EA!DC>>?@@AA!>A>=AHI!LCH!@EA?H!?9I?FE@!89B!AZJAH@?IAX!&!SC7KB!AIJAD?8KK5!K?;A!@C!@E89;!)HX!(98!&X!08[M7A[Y!>5!DC>>?@@AA!DE8?HX!<?@EC7@!EAH!AZDAKKA9@!8BG?DAY!?9J7@Y!89B!>A9@CHIE?JY!@EA!BCCH!CL!I@8@?I@?D8K!FA9A@?DI!SC7KB!9C@!E8GA!=AA9!CJA9ABY!89B!&!SC7KB!9C@!E8GA!=AA9!8=KA!@C!L?9?IE!>5!@EAI?IX!&!SC7KB!8KIC!K?;A!@C!@E89;!)HX!\789!4ABHC!.@A?=AKX!:?I!F7?B89DA!?9!@EA!>A@ECBCKCF5!CL!AT%1!898K5I?I!EAKJAB!>A!@C!=7?KB!@EA!EA8H@!CL!>5!@EAI?IX!!,?98KK5Y!&!SC7KB!K?;A!@C!@E89;!)HX!"7I@8GC!BA!KCI!'8>JCI!89B!)HX!\CIAJE!"8HB?9AH!LCH!@EA?H!JHCLAII?C98K!CJ?9?C9I!89B!?9G8K78=KA!?>JHCGA>A9@I!@C!>5!@EAI?IX!!&!8KIC!@E89;!>5!K8=!>A>=AHI!]A9?!2AH98KY!(F7I@?9!"C9[8KA[Y!89B!]CF8I7BE8!0A@7H?!LCH!@EA?H!I7JJCH@!?9!B8@8!898K5I?IY!I@8@?I@?D8K!ICL@S8HA!DCB?9FY!89B!@EA?H!L7H@EAH!EAKJ!?9!SH?@?9F!89B!DC9B7D@?9F!@EA!I@7B5X!%E89;I!8KIC!@C!@EA!A9@?HA!T789@"A9!HAIA8HDE!FHC7J!LCH!@EA?H!A9DC7H8FA>A9@!89B!@EA!I7JJCH@?GA!8@>CIJEAHA!@EA5!JHCG?BABX!&!SC7KB!K?;A!@C!HADCF9?[A!The Cancer Genome Atlas and Surveillance, Epidemiology, and End Results for making datasets available. 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V., Waller, S., Smith, T., & Hahn, T. 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Journal of Gerontology, 46(4), M139-M144.) 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nGene 1 2 3 4 5 6 7 8 9 nSNP 3,314 377 119 55 36 18 16 13 1 nGene 10 11 12 13 14 15 17 20!26 nSNP 6 6 1 1 3 1 1 1!1 nGene: number of significant genes per SNP; nSNP: amount of SNP. The significant eQTL (cis & trans) was filtered by FDR < 0.05.  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     0 copy     1 copy     2 copies Total rs3172494 294  (CC) 75  (AC) 8  (AA) 377 rs7698461 7  (GG) 61  (AG) 309  (AA) 377 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