IRIDIUM CATALYZED C-H BORYLATION: IMPROVED SELECTIVITY THROUGH CATALYST DESIGN AND THE VALUE OF SPECTROSCOPY UNDER CATALYTICALLY RELEVANT CONDITION By Behnaz Ghaffari        A DISSERTATION Submitted to Michigan State University in partial fulfillment of the requirements for the degree of Chemistry  Doctor of Philosophy 2016   ABSTRACT IRIDIUM CATALYZED C-H BORYLATION: IMPROVED SELECTIVITY THROUGH CATALYST DESIGN AND THE VALUE OF SPECTROSCOPY UNDER CATALYTICALLY RELEVANT CONDITION By Behnaz Ghaffari In homogeneous transition metal catalysis, the precatalyst usually needs to undergo a series of rearrangements or changes in the coordination sphere to form the active catalyst, which is responsible for the desired transformation. Isolation of these active intermediates along with mechanistic studies would provide greater insight to how the transformation works and would be extremely beneficial for modifying and designing a new catalyst/ligand system.  In Ir-catalyzed C-H activation/borylation, 5-coordinate iridium boryl species are reported to be the active catalytic species. Despite the initial report for utilizing phosphine ligands in thermal catalytic aromatic C-H borylation, bidentate nitrogen donor ligands have been used more frequently due to their higher reactivity.1 To analyze the origin of this difference, we studied a previously reported 5-coordinate iridium trisboryl complex stabilized by a bidentate phosphine ligand, which reacts directly with sp2 C-H bonds, providing a rare opportunity for examining the fundamental step in CH borylation. Previously, this complex had been shown to react stoichiometrically at room temperature, but under catalytic conditions elevated temperatures were required. We have found that the 16 electron 5-coordinate trisboryl complex and HBpin are in equilibrium with generating a six-coordinate borylene complex, which is the dominant species at the outset of the reaction. As borylation commences during the catalytic   reaction, the H2 produced from CH activation converts the borylene to a series of intermediates. These intermediates represent multiple resting states of CH borylation catalyst, which operate in parallel catalytic cycles. The complexes were isolated and characterized by 31P and 1H NMR, and X-ray crystallography, making this the most fully characterized catalytic system for CH borylation described to date. Insights from these studies are being used to design new bidentate catalysts for sp2 and sp3 CH functionalizations. In the second part of this dissertation, ortho directed C-H borylation of aromatic compounds will be discussed. In our novel approach without need of installation and removal of directing or protecting group, borylation of benzoates, benzamides, ketones, anisoles, and phenyl pyridines occurs ortho to the functional group. In this systems, 14-electron intermediates likely mediate these processes. We have shown that low-coordinate Ir precatalysts can be obtained by using donor ligands that incorporate pendant silanes. These species are active for directed CH borylations with a range of substrates. We will discuss mechanisms by which these catalysts operate, present structures that pertain to catalysis, and discuss substrate scope in the context of other methodologies.  iv           To My family  & those who dedicated their lives to peace and education    ~ Albert Einstein   v  ACKNOWLEDGMENTS  I would like to express my sincere and foremost appreciation to my advisor Professor Mitch Smith; I was delighted to work on fascinating chemistry that he discovered in his group; I was fortunate to learn from such a smart, knowledgeable and great scientist. Without his guidance and resolute help, this dissertation would not have always indebted to him.  I also like to offer a very genuine appreciation to Professor Rob Maleczka for his important suggestions and remarks during boron collaboration meetings, for his endless support throughout my doctoral studies, and serving as my committee member. Special and earnest thanks go to my other committee members, Professor Aaron Odom and Professor Thomas Hamann, for all their helpful guidance during my time at defense within a very short notice. ofessors Gary Blanchard, Babak Borhan and Late professor Greg Baker and all the admission committee that gave me the opportunity to come to Michigan State for graduate study. In addition, thank you to Dr. Richard Staples and Dr. Daniel Holmes for their valuable help with X-Ray crystallography and NMR studies. Special thanks go to Drs. Shane Krska and Peter Maligres from Merck for their great discussion on MSU-Merck collaborative projects.  vi  I owe many thanks to all my lab mates; Sean, Phil, John, Marie, Hong-tu, Buddha, Don, Kristin, Yu-Ling, Dmitry, Tim, Olivia, Po-Jen, Reza, Ryan and Tyler; I could not have wished for better lab mates than you, I was fortunate to work with great pool of scientists and learn a great deal from everyone. Yu-Ling and Olivia, I appreciate all your help with editing my dissertation, you made my last week of graduate school more pleasant. Thanks to Hao, Damith, Suzi, Fangyi, Aaron, Ruwi, Gayanthi, and Jonathan for all valuable discussion during the Maleczka-Smith group meeting. I also would like to  This voyage would not have been possible without the support of my family, thank you Mom and Dad, for cheering me in all of my pursuits and inspiring me to follow my dreams. I always knew that you believed in me and desired the best for me. Special thanks to my brother Omid, my sister Farnaz, my sister-in-law Azadeh and my nephew Artin, your love, support and encouragement was worth more than I can state on paper.  vii  TABLE OF CONTENTS  LIST OF TABLES ........................................................................................................... ix LIST OF FIGURES .......................................................................................................... x LIST OF ABBREVIATIONS AND SYMBOLS ......................................................... xvi CHAPTER ONE  INTRODUCTION ........................................................................... 1 General Introduction to Aromatic Functionalization .................................................. 1 Transition Metal CH Functionalization ..................................................................... 5 Boration of Hydrocarbons ........................................................................................... 9 Regio and Chemoselectivity of Transition Metal CHB Catalysts .............................. 14 Regioselectivity Origins in Ir-catalyzed CHBs .......................................................... 18 Electronic Effects in Ir-catalyzed CHBs. ................................................................... 19 Chelate-Directed, ortho selective Ir-catalyzed CHBs. ............................................... 20 Relay-Directed, ortho selective,  Ir-catalyzed CHBs. ................................................ 21 Hydrogen-bond directed, ortho selective Ir-catalyzed CHBs. ................................... 22 Other ortho-selective CHBs. ...................................................................................... 22 Meta-Selective CHBs. ................................................................................................. 23 Para-Selective CHBs. ................................................................................................. 24 REFERENCES ........................................................................................................... 25 CHAPTER 2  REVERSIBLE BORYLENE FORMATION FROM RING-OPENING OF PINACOLBORANE AND OTHER INTERMEDIATES GENERATED FROM 5-COORDINATE TRISBORYL COMPLEXES: IMPLICATIONS FOR CATALYTIC C-H BORYLATION ..................................... 32 Studies of 5-coordinate boryl catalysts. ..................................................................... 32 Results ........................................................................................................................ 34 Discussion .................................................................................................................. 45 Conclusions ................................................................................................................ 52 REFERENCES ........................................................................................................... 53 CHAPTER 3  SILYL PHOSPHORUS AND NITROGEN DONOR CHELATES FOR HOMOGENEOUS ORTHO BORYLATION .................................................... 56 Directed Aromatic Functionalization ......................................................................... 56 Results ........................................................................................................................ 58 Conclusions ................................................................................................................ 68 REFERENCES ........................................................................................................... 69 CHAPTER 4  EXPERIMENTAL ............................................................................... 72 General Procedures ................................................................................................... 72 Analytical Methods ..................................................................................................... 72  viii  X-ray Crystallography Details ................................................................................... 72 Computational Methods ............................................................................................. 73 Synthesis of compounds .............................................................................................. 74 REFERENCES ......................................................................................................... 110 APPENDICES ............................................................................................................... 113 APPENDIX A, NMR Spectra .................................................................................. 114 APPENDIX B, Crystal Data and Structure .............................................................. 173 APPENDIX C, Computational Results .................................................................... 178   ix  LIST OF TABLES  Table 1. Comparison of catalyst efficiency for ortho-borylation ..................................... 60 Table 2. Ortho-borylation of alkylbenzoates.a .................................................................. 61 Table 3. Borylations with 15/[Ir(OMe)(cod)]2 catalyst .................................................... 64 Table 4. Comparison of Silyl Ligands with Pendant P- and N-donors ............................. 67 Table 5. Comparing reactivity of  Ir-catalyzed CHB using ligand 15 and 20 ................ 109   x  LIST OF FIGURES  Figure 1. Nitration of benzene ............................................................................................ 2 Figure 2. Electrophilic aromatic substitution (EAS) .......................................................... 2 Figure 3. Regioselectivities of EAS for disubstituted arene (ortho/para directors shown in blue and meta directors shown in red) ................................................................................ 3 Figure 4. Synthesis of 3-bromo-5-chlorophenol ................................................................ 3 Figure 5. Early reports on DoM ......................................................................................... 4 Figure 6. Regioselectivity of DoM in presence of two directing groups ........................... 5 Figure 7. Synthesis of isolated C-H activated organometallic complex by Chatt and Davidson ............................................................................................................................. 6 Figure 8. Sterically directed C-H bond activation of aromatics by Ittel ............................ 7 Figure 9. Catalytic cyclization of 2,6-xylyl isocyanide ...................................................... 8 Figure 10. Meta selective, Rh-catalyzed silylation of meta-xylene. .................................. 9 Figure 11. Synthetic utility of arylboron compounds. ...................................................... 10 Figure 12. Methods for synthesizing C-B bonds .............................................................. 12 Figure 13. Thermodynamic calculation of methane C-H bond borylation ...................... 12 Figure 14. First thermal catalytic borylation of benzene .................................................. 13 Figure 15. Regio- and chemoselectivity of iridium and rhodium catalyzed borylation of aromatics ........................................................................................................................... 14 Figure 16. Iridium catalyzd CHB cycle reported by Smith and Maleczka ...................... 16 Figure 17. A proposed catalytic cycle for Ir-catalyzed CHB of arenes, heteroarenes, and alkanes ............................................................................................................................... 17 Figure 18. First attempt to quantify steric effect in Ir-catalyzed CHBs ........................... 18 Figure 19. Correlation -group charge ............................................. 19  xi  Figure 20. Chelate directed ortho borylation of benzoate using bulky, electron deficient, mono dentate phosphine ................................................................................................... 20 Figure 21. Solid supported Iridium catalyst for ortho-directed borylation ...................... 21 Figure 22. Silyl-Directed, Iridium-Catalyzed ortho-Borylation of Arenes ...................... 22 Figure 23. Mechanism for outer-sphere ortho-borylation ................................................ 22 Figure 24. Selective meta borylation by using a secondary interaction between ligand and the substrate ...................................................................................................................... 23 Figure 25. Directed meta C-H borylation by ion pair mechanism ................................... 24 Figure 26. Para selective C-H borylation by using the bulky ligand ................................ 24 Figure 27. Catalytic cycle for iridium catalyzed C-H borylation using bidentate ligand . 33 Figure 28. Proposed mechanism for borylene formation ................................................. 34 Figure 29. 11B NMR of compound 6 in benzene-d6 ......................................................... 35 Figure 30. Equilibrium between complex 6 with complex 5 and HBpin ......................... 36 Figure 31. X-ray structure for compound 8 with thermal ellipsoids calculated at 50% probability levels. The two independent molecules (8a and 8b) are shown with selected angles and distances .......................................................................................................... 38 Figure 32. Calculated structures (M06//SDD/6-31G*) for 8a and 8b (red) overlaid with coordinates from their X-ray structures (blue). Calculated bond distances and angles correspond to the numbering in Figure 31 ........................................................................ 40 Figure 33. X-ray structure for compound 9 with thermal ellipsoids calculated at 50% probability levels. Hydride ligands are shown and other hydrogens are omitted for clarity. Selected experimental and computational metric parameters are given ........................... 41 Figure 34. The calculated structure (red, M06//SDD/6-31G*) is overlaid with crystallographic coordinates ............................................................................................. 42 Figure 35. X-ray structure for compound 10 with thermal ellipsoids calculated at 50% probability levels. Hydride ligands are shown and other hydrogens are omitted for clarity, selected experimental metric parameters are given .......................................................... 43 Figure 36. The calculated structure (red, M06//SDD/6-31G*) is overlaid with crystallographic coordinates. Selected computational metric parameters are given ........ 44  xii  Figure 37. 31P{1H} NMR spectra showing catalysts evolution during the reaction ........ 44 Figure 38. Putative equilibria for hydride exchange in compound 8 ............................... 46 Figure 39. 1H NMR spectrum (500 MHz, toluene-d8, 5 °C) of the hydride region for compound 10 ..................................................................................................................... 48 Figure 40. Possible structures for compound 7 ................................................................ 50 Figure 41. H2 induced equilibria by H2 addition to compound 5 ..................................... 50 Figure 42. Parallel catalytic cycles for CH borylation ................................................... 51 Figure 43. Chelate assisted mechanism for bulky, electron deficient monodentate phosphine .......................................................................................................................... 57 Figure 44. Ortho borylation of phenylpyridine using hemilabile ligand .......................... 57 Figure 45. General chelate assisted mechanism for homogenous borylation .................. 58 Figure 46. Designing a bidentate, monoanionic ligand. ................................................... 58 Figure 47. Designing a bidentate, monoanionic ligand .................................................... 59 Figure 48. Ligand dependent borylation regioselectivity ................................................. 62 Figure 49. Crystal structure of compound 19 with H atoms omitted ............................... 66 Figure 50. Expansion of 1H NMR in benzene-d6 for calculation of equilibrium constant 75 Figure 51. Catalytic conversion of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin ........................................................................................................ 77 Figure 52. Catalytic intermediates for borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin. ........................................................................................ 78  Figure A 1. 31P{1H} NMR of reaction intermediates for catalytic borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin in cyclohexane-d12 ......................................................................................................................................... 114 Figure A 2. 31P{1H} NMR spectra in cyclohexane-d12  at the end of catalytic borylation run of 2-methylthiophene with 0.5 equivalents of  HBpin, mainly shows compound 10 ......................................................................................................................................... 115 Figure A 3. 1H NMR spectra of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10 116  xiii  Figure A 4. gCOSY spectrum of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10 117 Figure A 5. 1H31P HMQC spectrum of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10 ................................................................................................................... 118 Figure A 6. 31P{1H} NMR of reaction intermediates for early stage of catalytic conversion of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin ... 119 Figure A 7. Hydride region in 1H NMR spectra of reaction intermediates for early stage of catalytic borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin in toluene-d8. ....................................................................................................... 120 Figure A 8. 31P NMR spectrum with selective decoupling of aliphatic protons for compound 7 at -45 °C, (J= 9.9 Hz) ................................................................................. 121 Figure A 9. 31P NMR spectrum with selective decoupling of aliphatic protons for compound 9 (J= 18.3 Hz) ................................................................................................ 122 Figure A 10. 31P{1H} NMR of reaction of H2 with compound 5. 1) Initial spectrum at -45 °C, 2) At -15 °C after 10 sec of shaking the tube, 3) At rt after 15 minutes of shaking the tube .................................................................................................................................. 123 Figure A 11. Hydride region in 1H NMR spectra of reaction of H2 with compound 5 1) Initial 1HNMR at -45 °C, 2) At -15 °C after 10 sec of shaking the tube, 3) At rt after 15 minutes of shaking the mixture ....................................................................................... 124 Figure A 12. Hydride region in 1H NMR spectra of compound 10 in toluene d-8  at different temperatures ..................................................................................................... 125 Figure A 13. 31P{1H} NMR spectra of compound 10 in toluene d-8  at different temperatures .................................................................................................................... 126 Figure A 14. 1H NMR spectra of thermolysis of compound 10, in toluene d-8  at different temperatures .................................................................................................................... 126 Figure A 15. 31P{1H} NMR spectra of thermolysis of compound 10, in toluene d-8  at different temperatures ..................................................................................................... 127 Figure A 16. 1H NMR of compound 15 .......................................................................... 128 Figure A 17. 13C NMR of compound 15......................................................................... 129 Figure A 18. 31P NMR of compound 15 ......................................................................... 130  xiv  Figure A 19. 1H NMR of compound 16b ........................................................................ 131 Figure A 20. 13C NMR of compound 16b....................................................................... 132 Figure A 21. 1H NMR of compound 16e' ....................................................................... 133 Figure A 22. 13C NMR of compound 16e' ...................................................................... 134 Figure A 23. 1H NMR of compound 16f ........................................................................ 135 Figure A 24. 13C NMR of compound 16f ....................................................................... 136 Figure A 25. 1H NMR of compound 16i ......................................................................... 137 Figure A 26. 13C NMR of compound 16i ....................................................................... 138 Figure A 27. 19F NMR of compound 16i ........................................................................ 139 Figure A 28. 1H NMR of compound 16k' ....................................................................... 140 Figure A 29. 1H NMR of compound 16k' ....................................................................... 141 Figure A 30. 1H NMR of compound 16l ......................................................................... 142 Figure A 31. 13C NMR of compound 16l ....................................................................... 143 Figure A 32 19F NMR of compound 16l ......................................................................... 144 Figure A 33. 1H NMR of compound 16n ........................................................................ 145 Figure A 34. 13C NMR of compound 16n ....................................................................... 146 Figure A 35. 1H NMR of compound 16o ........................................................................ 147 Figure A 36. 13C NMR of compound 16o....................................................................... 148 Figure A 37. 19F NMR of compound 16o ....................................................................... 149 Figure A 38. 1H NMR of compound 18a ........................................................................ 150 Figure A 39. 13C NMR of compound 18a ....................................................................... 151 Figure A 40. 1H NMR of compound 18c ........................................................................ 152 Figure A 41. 13C NMR of compound 18c ....................................................................... 153  xv  Figure A 42. 1H NMR of compound 18d ........................................................................ 154 Figure A 43. 1H NMR of compound 18f ......................................................................... 155 Figure A 44. 13C NMR of compound 18f ....................................................................... 156 Figure A 45. 1H NMR of compound 18g ........................................................................ 157 Figure A 46. 13C NMR of compound 18g....................................................................... 158 Figure A 47. 1H NMR of compound 18i ......................................................................... 159 Figure A 48. 13C NMR of compound 18i ....................................................................... 160 Figure A 49. gCOSY NMR of compound 18i ................................................................ 161 Figure A 50. Expansion of gCOSY NMR of compound 18i .......................................... 162 Figure A 51. 1H NMR of compound 18j' ........................................................................ 163 Figure A 52. 13C NMR of compound 18j' ....................................................................... 164 Figure A 53. gCOSY NMR of compound 18j' ............................................................... 165 Figure A 54. Expansion of gCOSY NMR of compound 18j' ......................................... 166 Figure A 55. 1H NMR of compound 19 .......................................................................... 167 Figure A 56. 13C NMR of compound 19......................................................................... 168 Figure A 57. 31P NMR of compound 19 ......................................................................... 169 Figure A 58. 1H NMR of compound 20 .......................................................................... 170 Figure A 59. 1H NMR of compound 20 .......................................................................... 171 Figure A 60. 1H NMR of compound 22a ........................................................................ 172   xvi  LIST OF ABBREVIATIONS AND SYMBOLS  Å Ångstrom Ac acetyl BDE bond dissociation energy Bn benzyl Boc butoxycarbonyl BOX -bisoxazoline Bu butyl cat catecholate Cp cyclopentadienyl Cp* pentamethylcyclopentadienyl cod 1,5-cyclooctadiene coe cyclooctene Cy cyclohexyl DMG directed metallating group dmpe 1,2-bis(dimethylphosphino)ethane DoM directed ortho metalation dcpe 1,2-bis(dicyclohexylphosphino)ethane dippe 1,2-bis(di-iso-propylphosphino)ethane dmpe 1,2-bis(dimethylphosphino)ethane dppe 1,2-bis(diphenylphosphino)ethane dtbpy -di(tert-butyl)--bipyridine  xvii  E+ electrophile EAS electrophilic aromatic substitution EDG electron donating group EI electron ionization equiv equivalents ESI electrospray ionization Et ethyl  hapticity, denotes how many contiguous atoms of a ligand bind to a metal  EWG electron withdrawing group FG functional group GC gas chromatography gCOSY gradient-select correlated spectroscopy  HRMS high-resolution mass spectrometry Ind indenyl kcal mol-1 kilocalorie per mole  kappa, denotes how many, and which atoms of a ligand are binding Keq equilibrium constant  [M] metal [M]+ molecular ion peak m meta Me methyl Mes mesityl  xviii  mp melting point mu, denotes bridging ligand NAS nucleophilic aromatic substitution NMR nuclear magnetic resonance o ortho ORTEP Oak Ridge Thermal Ellipsoid Plot Program p para P(ArF)3 tris[3,5-bis(trifluoromethyl)phenyl]phosphine Ph phenyl pin pinacolate pKa acid dissociation constant at logarithmic scale ppm parts per million Pr propyl  R remaining attachments RT room temperature sec- secondary- SMAP silicon constrained monodentate phosphine t- tertiary- t1/2 half-life THF tetrahydrofuran TNT 2,4,6-trinitrotoluene TON turnover number  1  CHAPTER ONE  INTRODUCTION General Introduction to Aromatic Functionalization Rapid development in science and technology over the past several decades has made aromatic hydrocarbons of high value and interest to modern society. Aromatic hydrocarbons are widely used in fuels, various biologically active molecules, agrochemicals and pharmaceuticals, and have also made countless appearances in polymeric materials.1 Despite the need for a variety of aromatic hydrocarbons, the process of catalytic reforming is currently the major source of aromatic production, supplying raw aromatics including benzene, toluene and xylenes. Additional derivatization is necessary to substitute C-H bonds for other functional groups (FGs) to diversify these basic feedstocks for particular end use.2 The challenges with functionalizing hydrocarbons can be attributed to inherent properties, including their (i) low dipole moments (ii) high pKa values of C-H bonds and (iii) small polarizabilities. Despite these challenges, chemists have been able to functionalize aromatic C-H bonds by several methods including (1) aromatic substitution (2) deprotonation and (3) transition metal CH activation. In 1825, Faraday performed the reaction of benzene with nitric acid (Figure 1).3 A decade later, Mitscherlich determined that nitrobenzene was the product of the reaction, initiating intense research in electrophilic aromatic substitution (EAS), which remains a powerful tool for arene functionalization.4   2   Figure 1. Nitration of benzene   The regioselectivity of these transformations is dictated by the electronic properties of the substituents on the ring. For example, electron donating groups like amine, alkoxides, or halogens result in ortho/para functionalization. Holleman named these substituents as ortho/para directors. A second group of substituents are electron withdrawing through resonance (e.g. NO2 and C(O)R) and deactivate the arene toward ortho/para substitutions, which results in meta selectivity. These are called meta directors (Figure 2).5   Figure 2. Electrophilic aromatic substitution (EAS)  There are nine regioisomeric permutations for a disubstituted benzene where the substituents are chemically inequivalent. Of all possible combinations of ortho/para and meta directors, only one of them (1,3-disubstituted benzene with both meta director groups) yields a single regioisomer according the selectivity rules for EAS (Figure 3).   3   Figure 3. Regioselectivities of EAS for disubstituted arene (ortho/para directors shown in blue and meta directors shown in red)  For polysubstituted aromatics, the selectivities are influenced by combinations of electronic steric effects from all substituents. This makes the preparation of specific regioisomers a daunting task, especially for preparing compounds where meta regiochemistry of ortho/para directing groups is desired. This is illustrated by the preparation of 3-choro-5-bromophenol using conventional organic chemistry in Figure 4.6   Figure 4. Synthesis of 3-bromo-5-chlorophenol While aromatic CH bonds are very weak acids (the pKa of C6H6 = 37),7 they can be metalated in reactions with Group 1 and 2 metal alkyls and amides. The metalated arene intermediates can be converted to a range of arene products through reactions with electrophiles. Gilman in 1939, reported the deprotonation of a C-H bond in benzene ring  4  ortho to oxygen in dibenzofuran using lithium and sodium alkyls (Figure 5).8 Wittig, Pockels and Dröge were able to isolate ortho-methoxy-triphenylcarbinol (68% yield) by adding benzophenone to a mixture of phenyl lithium and anisole, and introduced the concept of the directing metalating group (DMG).9 This marked the beginning of directed ortho metalation (DoM), which is now a widely used synthetic method.10a-10c   Figure 5. Early reports on DoM  Subsequent research on several classes of substrates revealed that DMGs such as amides, carbamates, protected alcohols and tertiary amines may interact with metal reagents through a heteroatom in the substituted arene and direct the metalation to the ortho position. The deprotonation site can be predicted by considering several factors, including the electronic properties of the ring and the strength of DMG. In cases where two meta-related DMGs share an ortho CH site, the directing effect is reinforced. Thus, 1,3-DMG-substituted arenes exhibit high DoM selectivity for the 2-position. In contrast, the regioselectivity in 1,2 and 1,4-disubstituted arenes is determined by the relative power of the directing metalation group, which generates a competition for the base, yielding product mixtures (Figure 6).10a-10c  5   Figure 6. Regioselectivity of DoM in presence of two directing groups While DoM is a very powerful tool for functionalizing many arenes, there are some drawbacks. These include (1) restricted FG tolerance, (2) a necessity for at least a stoichiometric amount of metal (This increases when FGs are more acidic than the CH bonds present), and (3) a requirement of cryogenic temperatures. CH functionalization of hydrocarbons using EAS and DoM prove that the low reactivity of arene CH bonds toward functionalization can be overcome. Nevertheless, new complementary methods are particularly valuable for diversifying the chemist's synthetic toolbox.11-13    Transition Metal CH Functionalization Due to the shortcomings of previous methods, the direct functionalization of hydrocarbons using organometallic precursors has established a great deal of interest.14-22 The general process can be summarized as converting a CH bond to a CFG bond with the aid of a transition metal. The first example of what was later coined CH Complexes of Zerovalent Transition Metals with the Ditertiary Phosphine, Me2P·CH2·CH2·PMe223 Specifically, the authors stated that for the reduction of metal complexes of the formula M(dmpe)2Cl2, Sodium  6  naphthalenide is the most versatile reducing agent we have found but even it gave a hydrido-complex, apparently by taking hydrogen from the naphthalene, in the attempted preparation of [M(Me2P·CH2·CH2·PMe2)2] (M = Ru or Os). This reaction is still under investigation. The the first example where the product of CH activation by a transition metal complex was definitely characterized involved the reaction of azobenzene and nickelocene. This was reported by Kleiman and Dubeck in 1963, and the reaction may have been the first example of chelate-directed CH activation.24 In 1965 Chatt and Davidson published a detailed study of their grouppreliminary observations from 1962.25 When cis-Ru(dmpe)2Cl2 was reduced with Na in the presence of benzene, naphthalene, anthracene and phenanthrene, cis-Ru(dmpe)2(H)(aryl) (aryl = Ph, 2-naphtyl, 2-anthryl, and phenanthryl) compounds were isolated. They proposed that Ru(dmpe)2, generated from the reduction of cis-Ru(dmpe)2Cl2, oxidatively added at the least sterically hindered CH bond of the arene to give the final product (Figure 7).  Figure 7. Synthesis of isolated C-H activated organometallic complex by Chatt and Davidson   7  More than a decade later, Ittel and coworkers reported that C-H oxidative addition for iron analogs of the Chatt cis-Ru(dmpe)2(H)(aryl) compounds was reversible.26 They illustrated that activation of the CH bonds of toluene takes place with excellent regioselectivity at the least sterically-hindered position with an approximate statistical distribution of meta and para-tolyl isomers (Figure 8). This reaction was the earliest evidence that the regioselectivity of transition metal-mediated CH activation of monosubstituted benzenes could be sterically controlled, and the thermodynamic product arises from reaction of the strongest CH bonds. ustrated the potential for transition metal CH functionalizations to complement the selectivities of DoM and EAS.  Figure 8. Sterically directed C-H bond activation of aromatics by Ittel  The subsequent functionalization of the MC bonds that arose from CH activation in a catalytically compatible fashion proved to be far more challenging than  CH bond activation itself. In 1986, Jones and co-workers reported the first viable catalytic CH activation/functionalization reaction.27 Using 20 mol% cis-Ru(dmpe)2H2, they were able to catalytically achieve the formation of 7-methylindole in > 90% yield from 2,6-xylyl isocyanide via an intramolecular cyclization (Figure 9).   8   Figure 9. Catalytic cyclization of 2,6-xylyl isocyanide Their proposed catalytic cycle begins with H2 reductive elimination from cis-RuII(dmpe)2H2 to generate 16-electron square planar Ru0(dmpe)2. Isocyanide coordination, dissociation of one phosphine arm of dmpe, and CH oxidative addition of a substrate methyl group affords the CH activated intermediate. MC functionalization occurs via formal 1,1-insertion of the isocyanide into the RuC bond. Tautomerization gives the trans-2-indolyl species, which isomerizes to the cis-2-indolyl isomer that forms the product via CH reductive elimination, regenerating the active catalyst Ru0(dmpe)2 to close the cycle. Despite the numerous intramolecular C-H activation/ functionalization reactions that followed,28 intermolecular C-H activation/functionalization were limited to isotopic labeling with deuterium gas. The first example to expand this narrow scope was reported in 1998 by Berry and co-workers.29 Their dehydrogenative coupling of arenes and trialkylsilanes using a rhodium catalyst and a sacrificial olefin is shown Figure 10.  9   Figure 10. Meta selective, Rh-catalyzed silylation of meta-xylene.   This landmark paper showed that sterically selective stoichiometric CH oxidative additions that had been discovered more than 30 years earlier could be harnessed for catalysis. In particular, meta functionalizations of 1,3-substituted benzenes were possible, as illustrated in Fig. 10. Likewise, o-xylene gave a single product. Monosubstituted benzenes gave mixtures of meta and para products. The fact that trifluoromethylbenzene and toluene gave nearly statistical 2:1 meta:para ratios is consistent with steric effects dominating electronic effects on regioselectivity. Their reaction had limited FG tolerance, which may be one reason that this seminal discovery has not been heavily cited.29 Boration of Hydrocarbons  Organoboron reagents are used extensively in synthetic chemistry. These compounds can be easily converted to a broad range of FGs. They often serve as intermediates to access more complex compounds, including pharmaceuticals30 and agrochemicals, as well as fluorescent molecules31 and molecular transporters.32 The importance of organoborones may be best reflected by the fact that their synthesis and applications have been recognized twice by the Nobel committee. In 1979 -containing compounds into 33 Thirty-one years later, Akira Suzuki shared the 2010 Nobel Prize for utilizing organoboron compounds in  10  -catalyzed cross-catalytic CC bond formation, but aromatic and heteroaromatic boron reagents have much broader synthetic utility as shown in Figure 11, where BC bonds in organoboron compounds enable CX (X=halogen),34,35 CO ,36-39 CN,37,40 CCN,41 Caryl,42,43 and other  CC44-46 bond formation. It bears mentioning that many of these transformations can be performed in one-pot.38,47   Figure 11. Synthetic utility of arylboron compounds.   Advances in transition metal catalyzed coupling reactions during the past few decades have been heavily represented by reactions between organoboron reagents with carbon electrophilesthe Suzuki coupling reaction being the flagship example.48 Catalysts containing Pd8 and Ni9 have been particularly effective in making air stable organoboron compounds versatile reagents for the formation of carbon-carbon bonds. Currently, Zn, B, and Sn are commonly used metals in Pd-catalyzed cross-coupling.49 The higher air and moisture stability of organoboron reagents relative to organozinc analogs makes the former compounds more popular candidates for coupling reactions. Additionally, the lower toxicity of organoboron compounds relative to organostannanes adds to their appeal. There are several different routes for preparing of aryl boronic acids and esters. Aryl organoboron compounds are conventionally prepared from corresponding aryl  11  halides, which are converted to Grignard or organolithium intermediates. These are usually reacted with trialkyl borates and the boronic acids or esters are isolated after hydrolytic workup. These syntheses rely on the availability of aryl halides that are ideally prepared by direct halogenation of aromatic starting materials. The routes also require stoichiometric amounts of metals. From aromatic starting materials, at least two reaction vessels are required, and a stoichiometric metal halide waste stream is unavoidable. It should be noted that commercially available aryl halides are sometimes prepared via multistep processes. Thus, hidden steps from petrochemical or bio-based feedstocks can be associated with their use.  To avoid the requirement of stoichiometric metals, and their associated waste streams, approaches where arylboronates are prepared from aryl halides and borane reagents have been developed. The most commonly used embodiments use transition metal catalysts (e.g. Pd) (Figure 12).50 In addition to halides, triflates, diazonium salts51 and amines52 can also be utilized as aryl electrophiles. While this route improves FG tolerance, its regiodiversity is tied to that of available aryl electrophiles. Direct conversion of CH bond to CB bonds is potentially the most atom economical approach to their synthesis. These processes offer the potential for accessing regioisomers EAS and DoM cannot. As described below, this can be accomplished with both stoichiometric and catalytic chemistry. 53,54 More recently, there have been several reports on transition metal free C-B bond formation.55-57  12   Figure 12. Methods for synthesizing C-B bonds Fundamental studies regarding the chemistry of transition metal boryl complexes began in the early 1990s. While information on metal-ligand bond energies is vital in understanding what is thermodynamically viable, there was not much data available for boranes and none for transition metal boryl complexes. In 1994, Rablen and Hartwig58 reported calculations of BH and BC bond dissociation enthalpies to provide the first estimated Mboryl BDE. Using their computational data, and accepted values for CH and HH BDEs, the thermodynamic feasibility for the dehydrogenative coupling of CH and BH bonds was illustrated.58 The reaction seen in Figure 13, is essentially thermoneutral, therefore this transformation is a potentially practical process that required a kinetic solution.58-60   Figure 13. Thermodynamic calculation of methane C-H bond borylation   13  In 1993, Marder and coworkers synthesized Ir(6-C6H5Me)(Bcat)3, (Bcat = catecholboryl), from (5- C9H7)Ir(cod), (cod = 1,4-cyclooctadiene).61 Inspection of the GC-MS chromatograms from the supporting information of their paper reveals two species with masses corresponding to C7H7Bcatthe formula for toluene CH borylated products. Four years later, Hartwig reported the first C-H activation/ borylation reactions of aromatics and aliphatic substrates using stoichiometric amounts of Cp(OC)2FeBcat, (OC)5MnBcat and (OC)5ReBcat under photolytic conditions.62,63 The metal hydride products in these reactions are not reactive for this transformation and therefore prevented them from being catalytic. Subsequent chemistry from group has shown that bimetallic cooperativity makes turnover with Fe possible.64 In 1999, Smith and Iverson reported the first thermal catalytic aromatic C-H activation/borylation reaction using Cp*Ir(PMe3)Bpin(H) in the presence of HBpin, (Bpin = pinacolborane) as boron source at 150 °C with 3 turnovers (Figure 14). 65 While the intitial TONs (turn over numbers) were low, this was the first definitive example of thermal, catalytic CH borylation (CHB) of an arene.  Figure 14. First thermal catalytic borylation of benzene One year later, Hartwig and coworkers reported CHBs of benzene and terminal methyl groups of alkanes using substoichiometric quantities of of Cp*Rh(4-C6Me6).66 For benzene, CHB reaction temperatures maintained at 150 °C but TONs increased to 328. In  14  Rh-catalyzed silylations, sacrificial olefins were not necessary for catalysis.29 Regio and Chemoselectivity of Transition Metal CHB Catalysts Comparisons between the two catalytic systems for thermal CHB originally disclosed by Smith and Hartwig revealed differences in their arene selectivities.67 While Ir and Rh catalysts borylated the least sterically hindered position, the Ir sytstems developed by Smith and coworkers offered selectivity advantages, especially for substrates containing aryl CF or benzylic CH bonds (Figure 15).68   Figure 15. Regio- and chemoselectivity of iridium and rhodium catalyzed borylation of aromatics  Due to better regio- and chemoselectivities of the Ir CHB catalysts, further studies were carried out to better define the Ir catalytic manifold. The stoichiometric reaction of (6-mesitylene)Ir(Bpin)3  with benzene gave 3 equivalents (equiv) of borylated  benzene, but (6-mesitylene)Ir(Bpin)3 did not catalyze the reaction in the presence of excess HBpin.42 The addition of PMe3 to solutions of HBpin, (6-mesitylene)Ir(Bpin)3 and  15  benzene led to catalytic turnover (TON = 50, at 150 °C), a 20 fold improvement relative to Cp*Ir(PMe3)(E)(H). Maleczka, Smith, and coworkers performed several experiments to develop their mechanistic hypothesis for the catalytic reaction. The dissociation of PMe3 from Cp*Ir(PMe3)Bpin(H) was excluded based on the observation that CHB with Cp*IrH4, and the boryl complexes that rapidly form when it reacts with HBpin, is too slow for undetected intermediates generated PMe3 dissociation from Cp*Ir(PMe3)Bpin(H) to be viable. This was further supported by substantially different regioselectivities for anisole CHB with precatalysts Cp*Ir(PMe3)Bpin(H) and Cp*IrH4.  The evidence for the IrIII/IrV cycle that was first proposed by the Maleczka and Smith groups was circumstantial. A remarkable finding of their work was the demonstrated compatibility of aryl halides in Ir-catalyzed CHB. With the Ir(I) precatalyst [IrCl(cod)]2, aryl CI bonds did not survive CHB conditions. However, the aryl CI bonds were retained with the IrIII precatalyst, (6-mesitylene)Ir(Bpin)3. This implicated CI oxidative addition, a well-established reaction for IrI, as the source of aryl CI incompatibility when IrI precatalysts were used. Another observation that favors the IrIII/IrV cycle is the stoichiometric reactivity of the IrI complex (Ir(Bpin)(PMe3)4) and the IrIII complex (fac-Ir(Bpin)3(PMe3)3) with arenes. Both borylate benzene stoichiometrically. However, stoichiometric CHB for iodobenzene is only found for the IrIII  complex. The original catalytic proposed by Cho, et al. is shown in Figure 16.  16   Figure 16. Iridium catalyzd CHB cycle reported by Smith and Maleczka Other significant findings were reported in the 2002 Science article from the Maleczka-Smith collaboration. Due to difficulties in isolating (6-mesitylene)Ir(Bpin)3, (5-C9H7)Ir(cod) was tested as a precatalyst for borylation of aromatics since it is the starting material for preparing (6-mesitylene)Ir(Bpin)3. Indeed, solutions containing identical concentrations of (5-C9H7)Ir(cod) and bisphosphine ligands efficiently catalyzed CHB of arenes with high TONs and excellent steric selectivity.42 They also reported the first catalytic CHB of a heterocycle, the first use of an inert solvent, and a one-pot CHB/Suzuki cross-coupling. This was the first demonstration that the spent Ir CHB catalysts could enable subsequent transformations, including transition metal catalyzed reactions.  On the heels of the Maleczka-Smith report, Hartwig and coworkers disclosed a similar reaction, using an IrI precatalyst, 2,2´-bipyridine and B2pin2.69 While the system use of an air stable ligand improved this method, most of the substrates still required high temperatures and excess of arene (60 equiv).  17  Additional experimental42,69,70 and computational71 studies, as well as isolation of the catalyst precursor (dtbpy)Ir(Bpin)3(coe)72 along with independent synthesis of 16-electron (dippe)Ir(Bpin)3 and (dcpe)Ir(Bpin)373 aid in the identification of the active catalytic species and mechanistic cycle (Figure 17).  As depicted in Figure 17, an IrI precatalyst, a donor ligand (usually a bidentate ligand like dmpe, dtbpy, or dppe), and HBpin (or B2pin2, which is not shown) are proposed to generate the 16-electron intermediate (L2)Ir(Bpin)3. This species has been proposed as the intermediate responsible for CH activation, which is typically rate-determining. The commonly proposed product of CH activation is an IrV intermediate thought to arise from CH oxidative addition to (L2)Ir(Bpin)3. Subsequent reductive elimination of the borylated product from IrV affords a 16-electron, IrIII diboryl monohydride. Catalyst regeneration begins with oxidative addition of HBpin to IrIII diboryl monohydride yielding an 18-electron IrV species that reductively eliminates H2 to regenerate (L2)Ir(Bpin)3, which closes the catalytic cycle.   Figure 17. A proposed catalytic cycle for Ir-catalyzed CHB of arenes, heteroarenes, and alkanes  18   Regioselectivity Origins in Ir-catalyzed CHBs As described earlier, -catalyzed CHB was to harness steric effects that are significant in the oxidative additions of CH bonds to transition metal complexes. Indeed, when steric effects dominate, the regioselectivities for Ir-catalyzed CHBs often complement those for DoM and EAS. However, the steric effects in Ir-catalyzed CHBs is not evidence that electronic effects are unimportant. The complete separation of steric and electronic effects is impossible. That does not mean that these concepts are useless, and Ir-catalyzed CHB is useful for delineating relative contributions from steric and electronic effects, particularly in cases where .  The first attempt to quantify steric effects was reported by Smith and coworkers. They attempted to correlate regioselectivities for Ir-catalyzed CHBs of 1,4-disubstituted benzenes (Figure 18). Specifically, the ratios of 2- and 3-borylated isomers were correlated to a slightly modified model. While this work led to selective CHB ortho to nitrile groups, which are weak meta directors in EAS, more detailed studies were clearly warranted.74  Figure 18. First attempt to quantify steric effect in Ir-catalyzed CHBs  19  Electronic Effects in Ir-catalyzed CHBs.  Unlike many monosubstituted benzenes, Ir-catalyzed CHB of anisole using Cp*Ir(PMe3)Bpin(H), does not result in a statistical 2:1 ratio of meta and para products. Instead, the observed 4:1 meta:para ratio reflects modest meta selectivity.65 This arises from electronic effects associated with the OMe group. Another example of the electronic bias is when the sterically small fluorine FG exists in the molecule. For instance, by modifying the ligand, it is possible to obtain the 2-borylated product starting from 1,3-difluorobenzene. Maleczka, Singleton and Smith reported a theoretical calculation that the activation barriers (electronically diverse group of substrates and the energy difference between the reactants a strong correlation, they also demonstrated that there is a 75  Figure 19. -group charge  20   In 2014, Houk and Merlic studied the origin of Ir-catalyzed CHB of mono- and di- substituted arenes using density functional theory. Their computational studies suggest that the regioselectivity of the product is dictated by the interaction energy difference between iridium and arene carbon due to the late nature of the transition state.76 Chelate-Directed, ortho selective Ir-catalyzed CHBs.  In 2000, smith and coworkers first described ortho-selective borylation of benzamide using Cp*Rh(4 -C6Me6), with ortho: meta: para ratio 4:2:1,67  proposing the selectivity arose from chelate direction of a DMG. The other example of directed ortho borylation is chelate-assisted functionalization; in this method, ortho borylations rely on intrinsic substrate functionality. For instance, Ishiyama and Miyaura described ortho borylation of esters using electron deficient monodentate bulky phosphine (Figure 20).77   Figure 20. Chelate directed ortho borylation of benzoate using bulky, electron deficient, mono dentate phosphine Ito and Ishiyama reported ortho borylations of ketones;78 Lassaletta reported N-directed ortho-borylations of phenylpyridines using diimine ligands,79 and Clark and coworkers developed borylations of benzylamines and phosphines.80, 81  21  While the substrate scope for homogeneous ortho-directed iridium catalyzed borylation is limited, Sawamura pioneered heterogenous Ir-catalyzed borylations with a broad scope for ortho directed borylations (Figure 21).82-85  Figure 21. Solid supported Iridium catalyst for ortho-directed borylation While the surface supported phosphine systems of Sawamuras are highly active, their synthesis can be non-trivial, which makes modification of the phosphine structure challenging.86 Relay-Directed, ortho selective,  Ir-catalyzed CHBs. In 2008, Hartwig and Boebel described the first examples of iridium catalyzed ortho borylations using an organosilane moiety as a directing group.87 In this relay directed method, OH and NH bonds need to undergo silane protection to form OSiR2H and NSiR2H moieties. The SiH bonds go through formal sigma bond metathesis with IrBpin groups to create IrSi bound intermediates that direct functionalization of CH bonds ortho to O and N groups, but the necessity of a stoichiometric amount of protecting group is the drawback of this system (Figure 22).  22   Figure 22. Silyl-Directed, Iridium-Catalyzed ortho-Borylation of Arenes Hydrogen-bond directed, ortho selective Ir-catalyzed CHBs.  Recently, Maleczka, Singleton, and Smith have proposed that hydrogen bonding interactions between protected aniline (NBoc or NHBpin) N-H  bonds and Bpin O atoms can direct ortho borylations of anilines (Figure 23).88,89  Figure 23. Mechanism for outer-sphere ortho-borylation  Other ortho-selective CHBs.   Diborylation of indole results in substitution first at the 2-position and then at the 7-position.90 Several other methods have been reported that use an inner-sphere chelation or outer-sphere hydrogen bonding to perform ortho-borylation (more detailed information on ortho-directed borylation will be discussed in Chapter 3).    23  Meta-Selective CHBs.  Due to difficulties and challenges for selective meta functionalization, until 2015 the only meta selectivity could be achieved by use of Ir-- disubstituted arene. In 2015, Kanai and coworkers rep meta-selective CH borylation directed by a secondary interaction between ligand and substrate.91 In this method, the bipyridine ligand that coordinates to the iridium center has a pendant urea moiety and all the substrates that have been screened contain a carbonyl group. A secondary interaction between the urea moiety and carbonyl group (hydrogen-bond acceptor) in the substrate seats the metal center in the vicinity to the meta-CH bond and therefore affect the regioselectivity (Figure 24).  Figure 24. Selective meta borylation by using a secondary interaction between ligand and the substrate In 2016, Chattopadhyay reported the selective meta borylation of benzaldehydes. In this method, by addition of amine, the aldehyde is protected. The author suggested that an electrostatic interaction and a secondary interaction between the ligand (3,4,7,8-tetramethyl-1,10-phenanthroline) and the substrate are responsible for the high meta selectivity.92  24  In 2016, Phipps and coworkers reported a new methodology for selective meta-CH bond borylation. They have introduced an ion-pair interaction between an anionic pendant FG on their ligand and the aromatic quaternary ammonium salts in the substrates (Figure 25).93  Figure 25. Directed meta C-H borylation by ion pair mechanism Para-Selective CHBs. Recently, Itami and coworkers reported the C-H activation of para-selective arenes. By means of a very bulky phosphine ligand and bulky substituents on their monosubstituted aromatics, para-selectivity up to 91% can be obtained, demonstrating that steric factors between substrate and catalyst play a very important role in achieving the desired regioselectivity (Figure 26).94  Figure 26. Para selective C-H borylation by using the bulky ligand  25            REFERENCES  26  REFERENCES  1. Chenier, P. J. Derivatives of Basic Aromatics. In Survey of Industrial Chemistry; 3rd ed.; Kluwer Academic: New York, 2002, p 195-203.  2. Chenier, P. J. Basic Organic Chemicals. In Survey of Industrial Chemistry; 3rd ed.; Kluwer Academic: New York, 2002, p 130.  3. Faraday, M. Trans. Roy. Soc. (London) 1825, 115, 440.  4. Mitscherlich, E. Justus Liebigs Ann. Chem. 1834, 12, 308.  5. Holleman, A. F. Chem. Rev. 1924, 1, 187.  6. 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Kawamorita, S.; Miyazaki, T.; Ohmiya, H.; Iwai, T.; Sawamura, M. J. Am. Chem. Soc. 2011, 133, 19310  86. Recently, threefold cross-linked polystyrenetriphenylphosphane hybrid systems have been developed. Their synthesis is simpler and intial studies indicate that these function similar to silica-supported monophosphines.: Iwai, T.; Harada, T.; Hara, K.; Sawamura, M. Angew. Chem. Int. Ed. 2013, 52, 12322.  87. Boebel, T. A.; Hartwig, J. F. Tetrahedron 2008, 64, 6824.  88. Roosen, P. C.; Kallepalli, V. A.; Chattopadhyay, B.; Singleton, D. A.; Maleczka, R. E., Jr.; Smith, M. R., III J. Am. Chem. Soc. 2012, 134,11350.  89. Preshlock, S. M.; Plattner, D. L.; Maligres, P. E.; Krska, S. W.; Maleczka, R. E., Jr.; Smith, M. R., III Angew. Chem., Int. Ed. 2013, 52, 12915.  90. Paul, S.; Chotana, G. A.; Holmes, D.; Reichle, R. C.; Maleczka, R. E., Jr.; Smith, M. R., III J. Am. Chem. Soc. 2006, 128, 15552.  91. Kuninobu, Y.; Ida, H.; Nishi, M.; Kanai, M. Nat. Chem. 2015, 7, 712.  92. Bisht, R.; Chattopadhyay, B. J. Am. Chem. Soc. 2016, 138, 84.  93. Davis, H. J.;  Mihai, M. T.; Phipps, R. J. J. Am. Chem. Soc. 2016, 138, 12759.   31  94. Saito, Y.; Segawa, Y.; Itami, K. J. Am. Chem. Soc. 2015, 137, 5193.  32  CHAPTER 2  REVERSIBLE BORYLENE FORMATION FROM RING-OPENING OF PINACOLBORANE AND OTHER INTERMEDIATES GENERATED FROM 5-COORDINATE TRISBORYL COMPLEXES: IMPLICATIONS FOR CATALYTIC C-H BORYLATION  Studies of 5-coordinate boryl catalysts.  In homogeneous transition metal catalysis, precatalysts are frequently assembled in situ through reactions with ligands, rearrangements, and/or changes in the coordination sphere. Even then, catalyst resting states often require ligand dissociation to generate more reactive species that carry out the important reactions in a catalytic cycle. Isolation of true intermediates along with mechanistic studies of their reactivity can provide great insights into factors that contribute to reaction rates and catalyst selectivities. This informs the design of improved catalysts. In Ir-catalyzed CHB, 16-electron 5-coordinate iridium boryl species L2Ir(Bpin)3 (1, Figure 26 where L is a neutral, two-electron donor ligand, and L2 can represent neutral bidentate four-electron donors) are the proposed to mediate CH cleavage.1,2 Reported experimental data and calculations provide support for the cycle shown in Figure 27.  Despite the initial report that utilized phosphine ligands in thermal catalytic aromatic C-H borylation,1 bidentate nitrogen donor ligands have been used more frequently due to their higher reactivity.2 While phosphine ligated catalysts have received less attention, there are some computational studies which predict that the intermediates  33  that are generated by CH activation is different from the intermediate generated using bipyridine ligated system and these intermediates are IrIII borane adducts (2).3    Figure 27. Catalytic cycle for iridium catalyzed C-H borylation using bidentate ligand The most popular catalytic system for C-H borylation is the dtbpy/[Ir(OMe)-(cod)]2 ligand/precatalyst combination, where the trisboryl intermediate (dtbpy)Ir(Bpin)3 (3) is proposed to be the active catalyst for C-H activation. Detailed mechanistic studies have been performed using the precatalyst (dtbpy)Ir(Bpin)3(coe) (4). A pre-equilibrium dissociation of coe from compound 4 was proposed to the generation of intermediate 3, which has eluded detection.1 To analyze the origin of the reactivity difference between bisphosphine- and bipyridine-ligated systems, we studied our previously reported 5-coordinate iridium trisboryl complexes stabilized by a bidentate phosphine ligand of the general formula (dippe)Ir(boryl)3, (5).4 These compounds are rare examples where catalytically relevant  34  intermediates are isolable.4-6 Compound (5) reacts directly with sp2 C-H bonds, providing a rare opportunity for examining the fundamental step in CH borylation. Previously, this complex had been shown to react stoichiometrically at room temperature, but elevated temperatures were required to achieve catalytic turnover.  Results In previous work by Dr. Ghayoor Abbas Chotana,7 a color change was observed when HBpin was added to compound 5, and a new resonance was observed (67.24) in the 31P{1H} NMR spectrum. The X-ray crystal structure and spectroscopic data indicated that the resulted compound 6 is a borylene diborohydride that formed from ring-opening of HBpin and is presumably is the source of the hydride ligand (Figure 28).8 A number of borylene complexes have been reported.9-11 These are prepared by various synthetic routes, with the H2 elimination/BH activation described by Sabo-Etienne and coworkers bearing some similarity to the generation of compound 6 in that borylene formation is reversible and arises from BH activation.12 It is noteworthy that compound 6 is the first complex to have both boryl and borylene ligands in the metal coordination sphere.  Figure 28. Proposed mechanism for borylene formation  35  Compound 6 has three different resonances in 11B NMR spectra. The signal for OBpin moiety appears at  22.0 which is the most upfield signal among all. The resonance for the two iridium boryl ligands appears at  38.8, and the signal for boron atom in borylene is the most downfield resonance  54.5 (Figure 28). The 1H NMR spectrum confirms the presence of the hydride ligand by a high field triplet signal at  11.05 (|2JPH| = 19 Hz) in the 1H NMR spectrum. The NMR data including the coupling constant between P and H and also the narrow line will suggest that the hydride does not have any interaction with cis-boryl ligands and therefore is a classical hydride.   Figure 29. 11B NMR of compound 6 in benzene-d6 1H NMR spectrum of compound 6 in benzene-d6, showed resonances for HBpin and compound 5, which suggests that the compound 5 and HBpin are in equilibrium with compound 6 (Figure 30).   36   Figure 30. Equilibrium between complex 6 with complex 5 and HBpin Addition of HBpin to the mixture or placing the mixture under dynamic high vacuum shifts this equilibrium toward compound 6 vacuum removes HBpin and regenerates 5. Recording the 1H NMR spectrum we have noticed that methine signal for compound 5 and 6 are well separated so with the aid of the 1H NMR, we measured the equilibrium constant for this reaction to be Keq = 1.65 x 103 M1 (see experimental section for the calculation of equilibrium constant). In catalytic borylation of 2-methylthiophene with compound 5, the initial 31P{1H} NMR spectroscopy shows that compound 6 is the major species at the start point of the reaction. Catalytic borylation of 2-methylthiphene does not progress at room temperature, even though the t1/2 for stoichiometric borylation by compound 5 at similar concentrations is less than 5 minutes, this would suggest that compound 5 is responsible for borylation, and addition of HBpin shift the equilibrium towards compound 6 which would inhibit catalysis. Upon heating the catalytic reaction mixture at 100 °C, new resonances appears in 31P{1H} NMR spectra ( 53.42, 61.22, 66.75, and 77.78 , indicating that compound 6 converts to a series on intermediate, which their relative concentration changes depending on the reaction time, concentration of HBpin and 2-methylthiophene.    37  Only after heating the reaction for 5 minutes, the intensity of the resonance corresponding to compound 6 ( 67.24) in the 31P{1H} NMR spectrum decreases and a new signal appears at  53.42. Along with the changes in 31P{1H} NMR spectrum, a new triplet appears at  11.16 (|JPH| = 12 Hz) in 1H NMR spectrum. The relative integration of signals in 31P{1H} NMR and 1H NMR spectrum,  suggests that the new species contains two hydrides per dippe ligand. We assign this to a complex with the formula (dippe)Ir(H2Bpin3) (7). Considering this formulation, compound 7 can be generated independently by adding H2 to compound 5 (this will be discussed later).  After heating the NMR tube reaction for 10 minutes, the borylene resonances for compound 6 disappear in 11B NMR spectrum but boryl resonance at  37.7 are still present, and 31P{1H} NMR spectrum shows a new resonance at  61.22, in addition to the resonance for compound 7. This is assigned to the complex (dippe)Ir(H3Bpin2) (8) and a major resonance at  11.21 appeared as a broad triplet (|JPH| = 6 Hz) in the 1H NMR spectrum for compound 8.  While we were not able to isolate compound 8 in analytically pure form, single crystals were obtained by cooling solutions of compound 5 with a 10-fold excess of HBpin. The structure is depicted in Figure 31.   38   Figure 31. X-ray structure for compound 8 with thermal ellipsoids calculated at 50% probability levels. The two independent molecules (8a and 8b) are shown with selected angles and distances Two independent molecules appear in the unit cell (Figure 31), and these differ in the relative orientation of the boryl ligands. In independent molecule 8a, the boryl ligands are both cis to one of the phosphines with the PIr vector of the other phosphorus approximately bisecting the B1Ir1B2 angle. In the second independent molecule (8b), one boryl (B4) is trans to P3 and cis to P4, while the second boryl (B3) is cis to P3 and forms a P4Ir2B3 angle of 143.34(7)°. The IrB distances range from 2.095(2) to 2.117(3) Å and are slightly longer than the Ir-B bonds trans to phosphines in compound 5 (2.07(1) Å). Electron density was located in regions consistent with hydride ligands and  39  refined, but the difficulty in locating hydrides bound to Ir prevents definitive characterization of HB interactions, which contribute to the linewidth of the hydride resonance and the reduced magnitude of |1JPH|. The theoretical calculations done by Professor Milton Smith assist us in gaining more insight into the H3(Bpin)2 framework. Structures were optimized at an M06//SDD/6-31G* level of theory using the X-ray coordinates as a starting point. Figure 31 shows an overlay of the calculated structures (red) with the coordinates from the X-ray structures (blue). Isomer 8a is calculated to be 1.5 kcal more stable than isomer 8b. As can be seen in Figure 23, the calculated coordinates for 8a are shifted significantly from the experimentally determined ones. Essentially, B1 and B2 swing towards H2 leaving the B1Ir1B2 angle unchanged. The shift in the calculated structure allows for a significant BH interaction (1.48 Å) between B1 and H2 and eliminates any interaction between B2 and H3. The structure is best described as an agostic borane complex of an IrIII dihydridoboryl complex. For structure 8b, the calculated structure more closely resembles the experimentally determined one. The biggest changes are lengthening of the Ir2B3 distance and a shortening of the B3H4 distance. Like 8a, the calculated structure of 8b is best represented as an IrIII dihydridoboryl complex.  40   Figure 32. Calculated structures (M06//SDD/6-31G*) for 8a and 8b (red) overlaid with coordinates from their X-ray structures (blue). Calculated bond distances and angles correspond to the numbering in Figure 31 By sustained heating of the NMR tube containing the reaction mixture, the signal for compound 7 in the 31P{1H} NMR spectrum disappears and a new feature at  66.75 accompanied the resonance for compound 8. The 1H NMR spectrum depicts a new triplet at  11.90 (|JPH| = 17 Hz) for compound 9. By recording the 31P NMR spectrum with selective decoupling of the aliphatic protons while the hydride coupling is preserved, we can find the number of hydrides existing in the structure.  The resulting quintet (pentet) evidences that four hydrides are bound to iridium in the structure of compound 9. This  41  compound was crystallized by cooling a 1,3-bis(trifluoromethyl)benzene solution containing compounds 6, 8, and a 10-fold excess of HBpin to 30 °C. After several weeks crystals formed and X-ray diffraction revealed their structure to be (dippe)Ir(H4Bpin) (9, Figure 33). Compound 9 could be generated independently by exposing a THF solution of compound 5.   Figure 33. X-ray structure for compound 9 with thermal ellipsoids calculated at 50% probability levels. Hydride ligands are shown and other hydrogens are omitted for clarity. Selected experimental and computational metric parameters are given The crystal structure of compound 9 is shown in Figure 33. Hydrides were located and refined, but the usual caveat applies to the certainty of their positions. The Ir1B1 distance is relatively long compared to the other boryl ligands in this family of complexes and may reflect contributions from agostic borane or borohydride structures. We carried out calculations starting from the X-ray coordinates, and the calculated structure (red) is shown with its overlap to the crystallographic coordinates (blue). There is good agreement between the calculated and experimental structure with the biggest differences being the elongation of the Ir1B1 bond and B1H3 distance with a shortening of the B1H4 distance in the calculated structure, which is best described as a borane adduct of  42  an IrIII trihydride (Figure 34). Based on the 1H and 31P{1H} NMR data, the hydride positions are rapidly equilibrating on the NMR time scale.  Figure 34. The calculated structure (red, M06//SDD/6-31G*) is overlaid with crystallographic coordinates With sustained heating of the catalytic reaction mixture, the resonance for compound 9 loses intensity and a new resonance at  77.78 appears in the 31P{1H} NMR spectrum. The intensity of the resonance for compound 10 is a maximum at the end of reactions where the initial [HBpin]:[thiophene] = 0.5. Upon cooling the cyclcohexane-d12 solution of the catalytic reaction to 5 °C the 31P{1H} resonance for compound 10 resolves into four distinct features at  78.77, 78.07, 76.52, 76.16. These features are slightly temperature and solvent dependent as the 31P{1H} NMR spectrum in toluene-d8 solution at 68 ° has peaks at  77.46, 76.88, 75.79, and 74.96. 1H NMR spectra at 500 MHz, 5 °C in cyclohexane-d12 show a complex pattern in the hydride region with resonances clustered at  3.77, 13.23, and 22.55. The three resonances have equal integrations, and a 1H COSY spectrum indicates that they are all coupled. At 70 °C the two lower-field hydride region vanish and a broad high-field resonance is observed at  22.73 We were able to obtain X-ray quality crystals by dissolving the crude reaction mixture in pentane and cooling to 35 °C. The X-ray crystal structure in Figure 35  43  reveals a dimeric structure 10, where each Ir center is 2-bound to a dippe ligand. The structure was refined with the constraints of one bridging and two terminal hydrides for each Ir center using distances from the calculated structures. The bridging hydride was fixed with the shorter IrH distance. The hydride formulation is consistent with the hydride resonances in the high temperature NMR spectra (vide infra).  Figure 35. X-ray structure for compound 10 with thermal ellipsoids calculated at 50% probability levels. Hydride ligands are shown and other hydrogens are omitted for clarity, selected experimental metric parameters are given Calculations starting from the X-ray coordinates refine to a similar structure with a slight elongation of the Ir-Ir distance (Figure 36). Attempts to calculate the structure as [(dippe)IrH(µ-H)]2 with one terminal and one bridging hydride gave geometries where the non-hydrogen atoms were shifted significantly from the crystallographically determined positions.  44   Figure 36. The calculated structure (red, M06//SDD/6-31G*) is overlaid with crystallographic coordinates. Selected computational metric parameters are given As was discussed before we start the reaction by using compound 5 as catalyst but in the catalytic reaction condition compound 6, 7, 8, 9 and finally 10 will be formed. Figure 37 is demonstrating the 31P{1H} NMR spectra of catalyst during the course of reaction.  Figure 37. 31P{1H} NMR spectra showing catalysts evolution during the reaction   45  To verify the relationship between compounds 5, 7, 8, 9, and 10, an independent NMR experiment was performed. When a NMR tube containing a toluene-d8 solution of compound 5 precooled in liquid nitrogen bath and then was briefly exposed to H2, 31P{1H}, and 1H NMR spectra at 45 °C show that compound 7 is the major species in solution along with compound 8. 31P NMR spectra with selective decoupling of the aliphatic 1H region give a broad triplet at  53.56, which approves that two high-field Hs are chemically equivalent on the NMR time scale in compound 7. When the NMR tube was removed from the spectrometer and shaken to dissolve H2 in the headspace, compound 8 became the dominant species in solution.  By repeating this process, compound 8 was transformed to compound 9. Lastly, equilibration of compounds 8 and 9 with compound 10 was demonstrated by removing the H2 from an NMR tube where catalytic borylation was complete, leaving compound 10 as the major species. Addition of HBpin to the solution regenerated compounds 8 and 9. Discussion Compound 5 joins a handful of complexes that react directly with CH bonds without requiring prior ligand dissociation13-14 and is a rare example of square pyramidal 16-electron d6 complexes.15  In accord with the tenet that true reactive intermediates are rarely observed under catalytic conditions,16 compound 5 reacts with HBpin to form a more stable initial resting state in 18-electron borylene compound 6, and compound 5 is not detected as an intermediate during catalysis.  If compound 6 were the only resting state during catalysis and compound 5 were the only CH activating intermediate, CH borylation would be inhibited by HBpin since compound 5 is generated from compound 6 by its dissociation. This is not observed experimentally, as the H2 generated during CH  46  borylation sequentially shifts the resting state to 18-electron compounds 7, 8, and 9. Thus, these complexes are more stable than borylene compound 6.   1H NMR spectroscopy yields important information about the 18-electron catalytic resting states 7, 8, and 9. Significantly, the inequivalent hydride/borane/boryl positions indicated in the solid state structures of compounds 8 and 9 are exchanging rapidly on the NMR time in solution. In addition, a single methine resonance for the dippe isopropyl groups is observed even though the crystal structures in Figures 30 and 31 feature chemically distinct methine environments. These exchanges are intramolecular, since coupling to 31P is maintained, and exchange with free HBpin is not observed. The dynamic behavior suggests that minima in the potential energy surface are relatively shallow, which is supported by the fact that compound 8 crystallizes with structures where the orientations of the ligands differ significantly. Figure 38 shows a pathway where equilibration of -HBpin and -H2 intermediates would exchange the hydride ligands in structure 8b.   Figure 38. Putative equilibria for hydride exchange in compound 8  Similar mechanisms have been proposed to account for exchange in (3-C6H3-1,3-[OP(tBu)2]2)IrH2(2-HBpin).10,17 Calculations support -borane complexation in  47  compounds 8 and 9, which would account for the broadening of high field resonances in the 1H NMR spectra of these compounds. Compound 10 is related to other Ir phosphine complexes with bridging hydrides. The most relevant compound is [(dfepe)Ir(µ-H)(H)2]2 (11, dfepe = (C2F5)2PCH2CH2P(C2F5)2).18 The [(diphsophine)Ir]2 frameworks of compounds 10 and 11 are very similar, although the latter compound is disordered in the solid state. As in compound 11, the IrP distance in 10 for the phosphorus trans to the terminal hydride (2.315(2) Å) is significantly longer than the distance for the phosphorus trans to the bridging hydride (2.223(1) Å). This is consistent with the strong trans influence for terminal hydrides. In contrast, the spectroscopic features for compound 10 differ from those for compound 11. Both 1H and 31P{1H} NMR spectra (toluene-d8 solutions) for compound 10 are more complicated than would be expected for a static structure analogous to that in Figure 35. At 25 °C, the resonances in the hydride and methine regions for compound 10 are relatively broad, suggesting dynamic behavior for compound 10. At lower temperatures, the hydride resonances sharpen, and at 68 °C, the methine resonance begins to decoalesce with two broad peaks near  3.6. At higher temperature, the methine peaks coalesce to a broad resonance at  2.5. This implies that a second set of methine resonances should appear near  1.4 in the low temperature spectrum, where four methine resonances would be expected for the structure in Figure 35, but these are obscured by other features. At low temperature, the hydride region (Figure 39) is complexparticularly for the feature at ~  13.   48   Figure 39. 1H NMR spectrum (500 MHz, toluene-d8, 5 °C) of the hydride region for compound 10 We originally questioned whether a trace impurity gives rise to the triplet at   13.06, but this feature persisted when compound 10 was prepared independently from compound 9, generated in situ from compound 5 and H2, and 3 equiv of MeOH. At low temperature, the 31P NMR spectrum for compound 10 has four absorptions between  78.72 and 76.15 for the phosphorus nuclei, whereas compound 11 has a singlet at  84.3. The phosphorus atoms in the crystal structure of compound 10 (Figure 35) are clearly chemically inequivalent. Therefore, P-P coupling would be expected. Because the chemical shift differences are of similar energies to the expected coupling, we considered whether the 31P{1H} and 1H NMR spectra reflected second-order coupling. However, the spectra could not be successfully simulated. The 1H COSY spectrum for compound 10 indicates coupling between the features at  3.33, 13.00, and 22.12, but selective decoupling of specific hydride resonances did not simplify the other hydride resonances. Thus, H-H couplings are small. Selective 31P decoupling showed that the resonance at  3.33 is a doublet (|2JPH| = 166 Hz). In contrast, the apparent doublet centered at  22.12 did not collapse when the 31P resonances were irradiated, indicating that the two resonances at  21.83 and 22.40 represent two hydride environments this is consistent  49  with the observed spectra arising from two conformations with similar populations and the same formula as compound 10. From chemical shifts, we assign the resonances for compound 10 at  3.33 and 13.00 to terminal hydrides, and the resonances at  21.83 and 22.40 to bridging hydrides. This assignment is based on compound 11, where the terminal hydrides appear as doublet at  -7.09 (|2JPH| = 149 Hz)the approximate the average chemical shift of the two lower field hydride resonances in compound 10and the bridging hydrides are assigned to a resonance at  21.90. When the temperature is raised, the hydride resonances in the 1H NMR spectrum broaden, and at 70 °C the resonances clustered at  3.33 and 13.00 vanish, which would be consistent with exchange between these hydrides, as is the case for compound 11. In addition, the 31P resonances coalesce to a single resonance at  76.68. This supports exchange between the conformations observed at lower temperatures.  Coalescence of the lower field hydride resonances was not observed, because compound 10 converts to a new species at higher temperatures. This is indicated by a new major 31P NMR peak at  87.91 and 1H NMR peaks at  6.80 (dd), 12.33 (br), and 13.01 (br), which integrate as 2:1:2. While it is tempting to assign this as a pentahydride structure of the formula (dippe)IrH5, it is unclear what the sources of H2 would be, and there is a broad feature in the 31P NMR spectrum at ~  63 that we cannot assign. We have insufficient data to definitively assign a structure for this species.  Of the intermediates observed in the catalytic reaction, the ligation of H and Bpin ligands in compound 7 can only be tentatively assigned without a crystal structure. Forms 7a-c is possible (Figure 40). Access to structures 7a and 7b would lead to B-H coupling, which would account for the relatively broad hydride resonance for compound 7.  50  Equilibration with structure 7c allows for exchange if 7a or 7b are minimum energy structures. If 7c is the lowest energy structure, the equivalence of the H positions is directly accounted for. Access to structure 7c could also be relevant to catalysis (Figure 27), as H2 dissociation would generate C-H borylation intermediate 5.  Figure 40. Possible structures for compound 7 The shift in catalyst resting structures can be understood in terms of equilibria of boryl complexes and H2, whose concentration increases throughout the reaction. As shown in Figure 41, H2 equilibration with boryl complexes generates HBpin and hydride intermediates with successive substitution of H for Bpin at the Ir center.   Figure 41. H2 induced equilibria by H2 addition to compound 5   51  If CH borylation funnels exclusively through intermediate 5, H2 generation would significantly inhibit catalysis. This is not the case as borylation proceeds smoothly until compound 10 is the dominant solution species. Maintenance of borylation activity while compounds 7, 8 and 9 have significant concentrations can be reconciled if these species are resting states for catalytically competent tris (5), bis (12), and monoboryl (13) intermediates that operate in parallel catalytic borylation cycles, with similar borylation rates, as shown in Figure 42. This behavior is reminiscent of the stoichiometric reactivity of bipyridine-ligated compound 3, which reacts to generate diborylhydride and monoboryldihydride complexes in reactions with arenes.1 Potential roles for these complexes in catalysis were not examined, and trihydride complexes were not reported.  Figure 42. Parallel catalytic cycles for CH borylation    52  Conclusions The fact that compound 5 react directly with sp2-CH bonds provides a rare opportunity for examining the fundamental step in CH borylation. The combination of 31P and 1H NMR spectroscopy, X-ray crystallography, and theory makes it possible to characterize multiple resting states and to assess their roles under catalytically relevant conditions. Although catalysts with bidentate nitrogen donors have been used more extensively, recent chemistry of phosphine-ligated catalysts suggests that they have as yet unrealized potential.19-21 The work described herein provides a foundation for understanding catalysis in this family of compounds, which may aid in designing new borylation catalysts.22  53            REFERENCES  54  REFERENCES  1. Cho, J. Y.; Tse, M. K.; Holmes, D.; Maleczka, R. E., Jr.; Smith, M. R., III Science     2002, 295, 305.  2. Boller, T. M.; Murphy, J. M.; Hapke, M.; Ishiyama, T.; Miyaura, N.; Hartwig, J. F. J. Am. Chem. Soc. 2005, 127, 14263.  3. Haines, B. E.; Saito, Y.; Segawa, Y.; Itami, K.; Musaev, D. G. ACS Catal. 2016, 6, 7536.  4. a ) Nguyen, P.; Blom, H. P.; Westcott, S. A.; Taylor, N. J.; Marder, T. B. J. Am. Chem. Soc. 1993, 115, 9329. b ) Nguyen, P.; Blom, H. P.; Westcott, S. A.; Taylor, N. J.; Marder, T. B. J. Am. Chem. Soc. 1993, 115, 9329. c) Chotana, G. A.; Vanchura, B. A., II; Tse, M. K.; Staples, R. J.; Maleczka, R. E., Jr.; Smith, M. R., III Chem. Commun. 2009, 5731.  5. Iluc, V. M.; Miller, A. J. M.; Anderson, J. S.; Monreal, M. J.; Mehn, M. P.; Hillhouse, G. L. J. Am. Chem. Soc. 2011, 133, 13055.  6. Mindiola, D. J.; Hillhouse, G. L. J. Am. Chem. Soc. 2001, 123, 4623.  7. Ghayoor Abbas Chotana, IRIDIUM CATALYZED AROMATIC BORYLATION AND ITS APPLICATIONS IN ONE-POT PREPARATIONS OF SUBSTITUTED AROMATIC BUILDING BLOCK, Michigan State University, Ph.D dissertation, 2009.  8. Britt Andrew Vanchura, STABLE FIVE-COORDINATE TRISBORYL ANALOGS OF PROPOSED REACTIVE INTERMEDIATES IN Ir-MEDIATED CH BORYLATIONS, Michigan State University,Ph.D dissertation, 2010.   9. Braunschweig, H.; Dewhurst, R. D.; Gessner, V. H. Chem. Soc. Rev. 2013, 42, 3197.  10. Hebden, T. J.; Denney, M. C.; Pons, V.; Piccoli, P. M. B.; Koetzle, T. F.; Schultz, A. J.; Kaminsky, W.; Goldberg, K. I.; Heinekey, D. M. J. Am. Chem. Soc. 2008, 130, 10812.  11. Braunschweig, H.; Shang, R. Inorg. Chem. 2015, 54, 3099.  12. Alcaraz, G.; Helmstedt, U.; Clot, E.; Vendier, L.; Sabo-Etienne, S. J. Am. Chem. Soc. 2008, 130, 12878.   55  13. Thompson, M. E.; Baxter, S. M.; Bulls, A. R.; Burger, B. J.; Nolan, M. C.; Santarsiero, B. D.; Schaefer, W. P.; Bercaw, J. E. J. Am. Chem. Soc. 1987, 109, 203.  14. Watson, P. L. J. Am. Chem. Soc. 1983, 105, 6491.  15. Lam, W. H.; Shimada, S.; Batsanov, A. S.; Lin, Z.; Marder, T. B.; Cowan, J. A.; Howard, J. A. K.; Mason, S. A.; McIntyre, G. J. Organometallics 2003, 22, 4557.  16. Halpern, J. Science 1982, 217, 401.  17. López, A. M.; Mora, M.; Oñate, E. Organometallics 2015, 34, 941.  18. Schnabel, R. C.; Carroll, P. S.; Roddick, D. M. Organometallics 1996, 15, 655.  19. Saito, Y.; Segawa, Y.; Itami, K. J. Am. Chem. Soc. 2015, 137, 5193.  20. Ghaffari, B.; Preshlock, S. M.; Plattner, D. L.; Staples, R. J.; Maligres, P. E.; Krska, S. W.; Maleczka, R. E., Jr.; Smith, M. R., III J. Am. Chem. Soc. 2014, 136, 14345.  21. Press, L. P.; Kosanovich, A. J.; McCulloch, B. J.; Ozerov, O. V. J. Am. Chem. Soc. 2016, 138, 9487.  22. This work was previously published as a journal publication. Ghaffari, B.; Vanchura, B. A.; Chotana, G. A.; Staples, R. J.; Holmes, D.; Maleczka, R. E.; Smith, M. R.Organometallics 2015, 34, 4732.  56  CHAPTER 3  SILYL PHOSPHORUS AND NITROGEN DONOR CHELATES FOR HOMOGENEOUS ORTHO BORYLATION  Directed Aromatic Functionalization As stated in Chapter 1, steric factors control the regioselectivities of products obtained from Ir catalyzed C-H borylation of aromatics. Recently, chemists have been developing the methods that can complement steric direction. There have been several examples where borylation occurs ortho to a carbonyl via inner sphere chelate directed C-H borylation. In 2000, Smith and coworkers reported borylation of benzamide using Cp*Rh(4 -C6Me6), with ortho: meta: para ratio 4:2:1.1 In 2008, Hartwig and Boebel described the first examples of Ir-catalyzed ortho CHB using silyl as a directing group.2  More recently, Maleczka, Singleton, and Smith proposed that hydrogen bonding interactions between protected aniline N-H bonds and Bpin O atoms account for ortho CHB of certain anilines.3,4 Other examples of directed ortho CHB are chelate-assisted functionalizations. The first was reported by Ishiyama and Miyaura where ortho CHB of esters was possible when Ir catalysts were generated with electron deficient monodentate phosphines.5 Chelate directed ortho CHBs require two readily accessible metal coordination sites.  The DMG coordinates to one of them, while the second vacant site assists in CH scission. Bulky and electron deficient phosphine undergoes the ligand dissociation to provide the second vacant coordination site and then ortho directed functionalization can occur (Figure 43).   57   Figure 43. Chelate assisted mechanism for bulky, electron deficient monodentate phosphine Lassaletta has reported N-directed ortho-borylations of phenylpyridines using diimine ligands, while this system works very well, unfortunately the substrate scope is limited to phenylpyridines (Figure 44).6,7   Figure 44. Ortho borylation of phenylpyridine using hemilabile ligand  Ito and Ishiyama have reported ortho borylations of ketones;8 and Clark and coworkers have revealed borylations of benzylamines and phosphines.9,10 Although detailed kinetic studies have not been reported, mechanism where two coordination sites in the catalyst are available to the substrate, are most probable (Figure 45). One site enables coordination of a directed metalating group (DMG) while the other is necessary to cleave the ortho CH bond.   58    Figure 45. General chelate assisted mechanism for homogenous borylation While the substrate scope for homogeneous ortho-directed iridium catalyzed borylation is limited, Sawamura pioneered heterogenous Ir-catalyzed borylations with a broad scope for ortho directed borylations.11-15   Results Thus, we sought an appropriate ligand framework for homogeneous catalysis that could mimic these heterogeneous catalysts. Given that tridentate PSiP pincer ligands have been utilized in CH borylation,16 we were hopeful that bidentate Si-P ligands could generate structures 14, where the silyl ligand replaces a spectating boryl (Figure 41).  Figure 46. Designing a bidentate, monoanionic ligand.  59   Silane metathesis with a boryl ligand would steer the phosphine to the metal center to generate intermediates (14) with accessible coordination sites. In contrast to other homogeneous approaches where electron deficient ligands are used to achieve coordinative unsaturation, our strategy would create an electron rich framework that facilitates CH cleavage.17 If this approach proved to be viable, the ligand framework could be modified in substantive ways. For example, silanes with pendant N-donors (or other basic ligands) could be targeted.  To test our idea, we prepared ligand 15 (Figure 47), using a protocol related to the synthesis of (2-diphenylphosphinophenyl)diphenylsilane.18 The synthesis is straightforward, modular, and scalable to gram quantities.   Figure 47. Designing a bidentate, monoanionic ligand  With 15 in hand, we tested it for the CH borylation of methylbenzoate. Table 1 shows the results compared to those obtained for catalysts generate from [Ir(OMe)(cod)]2 and P(3,5-bis(trifluoromethyl)phenyl)3 (PArF3) or triphenylarsine, which have both been used in directed borylations. As can be seen in entry 1, ligand 15 allows for the full conversion of B2pin2 and some of the generated HBpin, while the PArF3 and AsPh3 give considerably lower conversions. In contrast, silica-SMAP ligated Ir catalysts are significantly more active.  60  Table 1. Comparison of catalyst efficiency for ortho-borylation   With promising preliminary data in hand, we explored a number of substituted methyl benzoates these are shown in Table 2. The reactions were performed under identical conditions and reaction times were not optimized.   61  Table 2. Ortho-borylation of alkylbenzoates.a      62  Yields range from fair to excellent with the lowest yields corresponding to methylbenzoates that were only substituted at the 4-position. For these substrates, significant amounts of 2,6-diborylated compounds form, which accounts for the diminished yield of monoborylated products 16i and 16k. Some diborylation was also observed in the synthesis of 16e. It is noteworthy that lowering the catalyst loading to 0.5 mol % and reducing the temperature to 60 °C gave a 6% yield increase for 16k. In addition, diborylation is not observed for t-butylbenzoate in contrast to methylbenzoate. Lastly, the selectivity difference for ligand 15 relative to 4,4´-di(t-butyl)bipyridine (dtbpy) is highlighted in Figure 48, where different regioisomers are obtained in the borylations of 2-fluoro-4-bromomethylbenzoate.  Figure 48. Ligand dependent borylation regioselectivity  Given the results in Table 2, we further explored the scope with respect to substrate and directing group, and the results are given in Table 3. Entry 1 shows that unsubstituted benzamides give excellent conversions to monoborylated substrates without resorting to using excess arene to minimize diborylation as is required for methyl  63  benzoate. Entry 2 shows that the amide DMG trumps Cl direction. In fact, chlorobenzene does not give ortho borylated product with 15, contrasting the high ortho selectivity for Ir-SMAP catalysts. In entry 3, diborylated product 18c was obtained. When 1 equiv B2pin2 was used with 17c, selectivity for borylation ortho to the amide vs. the ester was 4.2:1. Entries 4 and 5 show that OMe can direct borylation to the ortho position, albeit in modest yield. This sets the chemistry of catalysts generated from ligand 15 apart from that of silica-SMAP, where borylation of 17d gives a 1:1 ratio of o:m+p borylated products. Entry 6 shows that esters are stronger DMGs that OMe, which is in line with SMAP supported catalysts. In entry 7, Weinreb amide 17g is converted cleanly to ortho-borylated product 18g. Borylation of 1-methylnaphthoate, 17i, gives a single isomer where functionalization of the -CH bond is favored over the -CH position. Borylation of thiophene substrate 17h at 60 °C gave slightly better selectivity (14:1) for 3 vs. 5-borylated products than that reported for the borylation with Ir-SMAP catalysts (9:1 at 80 °C). In contrast to the SMAP system, where the Ir catalysts are ineffective for borylation of 17j, borylation gives the products obtained by Lassaletta using hemilabile N,N ligands.8a Our reaction was performed at a lower temperature (60 vs. 80 °C) and a shorter reaction time (2 vs. 48 h). This was offset by a higher catalyst loading in our study (1.25 mol % vs. 0.5 mol %) and the formation of ~ 15% di-orthoborylated product. With 2.0 equiv B2pin2, this was the major product (Table 3).     64  Table 3. Borylations with 15/[Ir(OMe)(cod)]2 catalyst   65  The generation of active catalyst from 15, B2pin2, and [Ir(OMe)(cod)]2 raises interesting questions with regard to how an IrSi bond is generated, if it is formed at all. Several literature reports describe the metathesis of MOR and SiH bonds to make MH and SiOR products. However, silane directed borylations invoke MB/SiH metatheses to generate MSi and BH bonds. Thus, we considered that initial formation of IrBpin intermediates and subsequent IrB/SiH metathesis could account for the formation of intermediates such as 14.  Nevertheless, we performed a control experiment where 15 and [Ir(OMe)(cod)]2 were reacted. 31P and 1H NMR indicate rapid and quantitative conversion to compound 19 and methanolan unprecedented reaction for a silane with a metal alkoxide (Eq 1).   This is critical for establishing a 1:1 ratio of 15: Ir, which is the key to creating sites for DMG coordination and CH activation as posited for structure 14. The structure of 19 was confirmed by X-ray crystallography and is shown in Figure 49.  Using the centroids of the cod bound carbons as coordinates, the sum of the angles about Ir is 370°, which is close to the value for square-planar IrI. The IrC and CC distances for the carbons trans to Si are significantly longer than those for carbons trans to P, which is consistent with strong donation from Si to Ir.      66   Figure 49. Crystal structure of compound 19 with H atoms omitted Selected distances (Å) and angles (°): IrSi (2.376(2)), IrP (2.260(2)), IrC1 (2.246(8)), IrC2 (2.217(8)), IrC5 (2.194(8)), IrC6 (2.161(8)), C1C2 (1.386(12)), C5C6 (1.357(13)), PIrSi (83.53(6)), PIrcentroidC1C2 (96.72), SiIrcentroidC5C6 (95.39), centroidC1C2IrcentroidC5C6 (85.25)  Even so, some substrates proved to be challenging for borylations carried out with ligand 15. For example, carbamates react sluggishly, and ketones give significant amounts of ketone reduction. Since Ir catalysts supported by N-donor ligands in most cases prove to be more reactive than their P-donor counterparts,19 we reasoned that an N-donor analog of 15 might exhibit better reactivity with carbamates and ketones. Thus, quinoline based ligand 20 was prepared, and Ir catalysis with this ligand was evaluated relative to ligand 15 for compounds 21a and 21b.20,21   67  As shown in Table 4, ligand 20 outperforms its phosphine analog 15 for borylations of 21a and 21b. In the case of carbamate 21a, we see higher conversion, but slightly lower isolated yield to that reported by Sawamura for the related diethylcarbamate substrate. Perhaps more significantly, catalysis with 20 did not yield detectable borylation para to the carbamate, which is a minor byproduct in the silica-SMAP system.  Table 4. Comparison of Silyl Ligands with Pendant P- and N-donors    68   For phenyl ethyl ketone, ligand 15 gave the reduction to the alcohol upon workup as the major product. This unwanted reaction was almost completely eliminated by employing N-donor ligand 20. When compared to other homogenous catalysts that effect ortho borylation of ketones,8 borylations employing 20 had shorter reaction times at considerably lower temperatures.  Furthermore, borylations of t-butylbenzoate and benzamide 17a with ligand 20, using identical conditions to those used with ligand 15, gave 16m in 78% isolated yield after 3 h and 18a in 80% yield after 4 h, respectively. Significantly, ortho borylation of anisole was not found with ligand 20. These results show that modification of the silyl ligand framework can dramatically impact reactivity.  Conclusions In summary, we have shown that Ir catalysts supported by silyl-tethered P- and N-donor ligands are effective for ortho borylation directed by a range of different functional groups. Because the ligands within the coordination sphere are bidentate and electron-rich, the activities are generally superior to homogeneous systems that utilize electron-poor ligands to favor unsaturated intermediates. Exploring effects of varying the ligand framework on the reactivity in other directed CH functionalizations is of interest.22,23  69            REFERENCES  70  REFERENCES  1. Cho, J.-Y.; Iverson, C. N.; Smith, M. R., III J. Am. Chem. Soc. 2000, 122, 12868.  2. Boebel, T. A.; Hartwig, J. F. J. Am. Chem. Soc. 2008, 130, 7534.  3. Preshlock, S. M.; Plattner, D. L.; Maligres, P. E.; Krska, S. W.; Maleczka, R. E., Jr.; Smith, M. R., IIIAngew. Chem., Int. Ed. 2013, 52, 12915.  4. Roosen, P. C.; Kallepalli, V. A.; Chattopadhyay, B.; Singleton, D. A.; Maleczka, R. E., Jr.; Smith, M. R., III J. Am. Chem. Soc. 2012, 134,11350.  5. Ishiyama, T.; Isou, H.; Kikuchi, T.; Miyaura, N. Chem. Commun. 2010, 159.  6. Ros, A.; Estepa, B.; Lopez Rodriguez, R.; Alvarez, E.; Fernandez, R.;  Lassaletta, J. M. Angew. Chem., Int. Ed. 2011, 50, 11724.  7. López-Rodríguez, R.; Ros, A.; Fernández, R.; Lassaletta, J. M. J. Org. Chem. 2012, 77, 9915.  8. Itoh, H.; Kikuchi, T.; Ishiyama, T.; Miyaura, N. Chem. Lett. 2011, 40, 1007.  9. Roering, A. J.; Hale, L. V. A.; Squier, P. A.; Ringgold, M. A.; Wiederspan, E. R.; Clark, T. B. Org. Lett. 2012, 14, 3558.  10. Crawford, K. M.; Ramseyer, T. R.; Daley, C. J. A.; Clark, T. B.Angew. Chem., Int. Ed. 2014, 53, 7589.  11. Kawamorita, S.; Ohmiya, H.; Hara, K.; Fukuoka, A.; Sawamura, M. J. Am. Chem. Soc. 2009, 131, 5058.  12. Kawamorita, S.; Ohmiya, H.; Sawamura, M. J. Org. Chem. 2010, 75, 3855.  13. Kawamorita, S.; Murakami, R.; Iwai, T.; Sawamura, M. J. Am. Chem. Soc. 2013, 135, 2947.  14. Kawamorita, S.; Miyazaki, T.; Ohmiya, H.; Iwai, T.; Sawamura, M. J. Am. Chem. Soc. 2011, 133, 19310  15. Recently, threefold cross-linked polystyrenetriphenylphosphane hybrid systems have been developed. Their synthesis is simpler and intial studies indicate that these function similar to silica-supported monophosphines.: Iwai, T.; Harada, T.; Hara, K.; Sawamura, M. Angew. Chem. Int. Ed. 2013, 52, 12322.   71  16. Fang, H.; Choe, Y.-K.; Li, Y.; Shimada, S. Chem. Asian J. 2011, 6, 2512.  17. Vanchura, B. A.; Preshlock, S. M.; Roosen, P. C.; Kallepalli, V. A.; Staples, R. J.; Maleczka, R. E., Jr.; Singleton, D. A.; Smith, M. R., III Chem. Commun. 2010, 46, 7724.  18. Zhang, F.; Wang, L.; Chang, S.-H.; Huang, K.-L.; Chi, Y.; Hung, W.-Y.; Chen, C.-M.; Lee, G.-H.; Chou, P.-T. Dalton Trans. 2013, 42, 7111.  19. Preshlock, S. M.; Ghaffari, B.; Maligres, P. E.; Krska, S. W.; Maleczka, R. E., Jr.; Smith, M. R., III J. Am. Chem. Soc. 2013, 135, 7572.  20. Stradiotto, M.; Fujdala, K. L.; Tilley, T. D. Chem. Commun. 2001, 1200.  21. Sangtrirutnugul, P.; Tilley, T. D. Organometallics 2007, 26, 5557.  22. Some of this work was previously partially presented in a) Sean Micheal Preshlock, STOICHIOMETRIC AND CATALYTIC CH BORYLATIONS OF ARENES, Michigan State University, Ph.D dissertation, 2013 b) Donald Plattner, THE IRIDIUM CATALYZED ORTHO BORYLATION OF AROMATICS, Michigan State University, Msc dissertation, 2014.  23. This work was previously published as a journal publication. Ghaffari, B.; Preshlock, S. M.; Plattner, D. L.; Staples, R. J.; Maligres, P. E.; Krska, S. W.; Maleczka, R. E.; Smith, M. R. J. Am. Chem. Soc. 2014, 136, 14345.   72  CHAPTER 4  EXPERIMENTAL  General Procedures All commercially available chemicals were used as received unless otherwise indicated. Pinacolborane (HBpin containing 1% NEt3) and was generously supplied by BoroPharm, Inc. (6-mesitylene)Ir(Bpin)3 and compound 5 were prepared per the literature procedures.1 Solvents were refluxed over sodium benzophenone ketyl, distilled, and degassed. All the experiments were carried out in a glove box under a nitrogen atmosphere or by using standard Schlenk techniques.  Analytical Methods 1H NMR spectra were recorded on a Varian VXR-500 or Varian Unity-500-Plus spectrometer (499.74 MHz) and referenced to residual solvent signals. 11B NMR spectra were recorded on Varian VXR-500 operating at 160.41 MHz. 31P NMR spectra were recorded on Varian Unity-500-Plus operating at 202.29 MHz. 11B and 31P NMR spectra were indirectly referenced relative to SiMe4 according to IUPAC standard using VnmrJ software. All coupling constants are apparent J values measured at the indicated field strengths. Melting points were measured on a MEL-TEMP or Thomas Hoover capillary melting apparatus and are uncorrected. Note: Because all of the compounds are in equilibrium with each other, it was not possible to isolate bulk samples containing one species for combustion analysis. X-ray Crystallography Details Crystal Structures of compounds 6, 8, 9, and 10 were performed using a Bruker CCD x-ray diffractometer and associated software applying standard crystallographic  73  techniques.  Specifics for compound 6 include a disorder model for on boryl group, modeled at a 50:50 population.  No restraints or constraints were performed to keep the groups together, although the thermal parameters were large for oxygen atoms on one of the boryls.  Compounds 8, and 9 were solved without incident, and the hydride atoms were found and refined isotropically. Compound 10 was solved without a problem, but the hydride atoms on the Ir atom could not be located.  These were then modeled as riding atoms based on calculated positions generated in theoretical calculations (red, M06//SDD/6-31G*). Computational Methods DFT quantum chemical calculations were carried out using the Gaussian 09 software suite (Revision D.01)2 using the M06 functional.3 A split basis set was employed with an SDD basis and core potential on Ir, and a 6-31G* basis set on the other atoms. Structures were minimized until program default convergence limits were reached.  74  Synthesis of compounds Synthesis of (dippe)IrH(Bpin)2(=BOCMe2CMe2OBpin) (6) HBpin (8.7 µL, 0.06 mmol, 1 equiv) was added to a pentane solution (1.0 ml) of compound 5 (50 mg, 0.06 mmol, 1 equiv) in a 20 mL scintillation vial. The initially yellow solution lightened upon addition of the HBpin. The resulting solution was stirred for approximately 2 minutes when a white precipitate began forming. The vial was placed in a freezer at 35 °C and allowed to sit overnight. The next day the mother liquor was pipetted from the vial, leaving a white solid on the sides of the vial. Nitrogen was blown from a pipette to dry the white solid (43 mg, 75%, mp 151-153 °C).  When the solid was placed back into solution for NMR characterization, the yellow color of the initial reaction solution reappeared. 1H NMR (benzene-d6, 500 MHz):  2.37-2.30 (m, 2 H), 1.97 (s, 6 H), 1.80-1.72 (m, 2 H), 1.68 (s, 6 H), 1.29 (s, 28 H), 1.19-1.12 (m, 6 H), 1.12-1.06 (m, 6 H), 1.06-1.00 (m, 18 H, boryl singlet 1.05 ppm), 0.94-0.89 (m, 6 H), 11.05 (t, J = 19.3 Hz); 11B NMR (benzene-d6, 160 MHz):   22.0, 38.8, 54.5; 31P NMR (benzene-d6, 202 MHz):   67.24 Calculation of the equilibrium constant between compound 5, HBpin, and compound 6 0.01 mmol of compound 6 was weighed in a test tube and then transferred to a J. Young tube after dissolution in benzene-d6 (500 L). When recording the 31P{Borreguero,  #105} and 1H NMR spectra, peaks for compounds 6 (67.24 ppm) and 5 (86.35 ppm) were observed in a roughly 3:1 ratio. The equilibrium constant was calculated from molar ratios determined by integrating resonances in the 1H NMR  75  spectrum for the HBpin hydride and the methine protons in compounds 5 and 6 (compound 6 has two sets methine peaks), which gave Keq = 0.00165 mol·L-1   Figure 50. Expansion of 1H NMR in benzene-d6 for calculation of equilibrium constant            Normalized value for one methine hydrogen in compound 5           Normalized value for one methine hydrogen in compound 6   Total normalized value for one methine hydrogen in compound 5 and 6              Fraction of compound 5 in Iridium mixture             Fraction of compound 6 in Iridium mixture      Fraction of HBpin in mixture based on value for compound 5 Initial mmol of compound 6 = 0.01 mmol        Volume of solvent = 0.5 mL  76         mmol of compound 5        mmol of compound 6         mmol of HBpin          molarity of compound 5            molarity of compound 6      molarity of HBpin     77  Catalytic borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin Compound 5 (20.8 mg, 0.025 mmol, 0.05 equiv) was weighed in a test tube and then transferred to a J. Young NMR tube after dissolution in cyclohexane-d12 (150 L × 4). 2-methylthiophene (49 L, 0.5 mmol, 1 equiv) and HBpin (36 L, 0.25 mmol, 0.5 equiv) were then added to the J. Young NMR tube via syringe. The J. Young NMR tube was capped and heated in the NMR probe at 100 °C. The reaction was monitored by 1H and 31P{1H} NMR spectroscopy every 20 minutes for conversion of starting material as well as catalyst intermediates for 4 hours which the NMR yield of 4,4,5,5-tetramethyl-2-(5-methylthiophen-2-yl)-1,3,2-dioxaborolane was showing full conversion based of limiting reagent (HBpin) see Figures 51 and 52.  Figure 51. Catalytic conversion of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin   % conversion of 2-Methylthiophene    78   Figure 52. Catalytic intermediates for borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin.  Generation of (dippe)Ir(H)2(Bpin)3 (7)  A toluene-d8 solution (0.6 mL) of compound 5 (20.8 mg, 0.025 mmol, 1 equiv) was added to a J. Young NMR tube. The tube was connected to a Schlenk line and then subjected to three freeze-pump-thaw cycles. The tube was opened to an atmosphere of H2 gas, closed, and then placed in a precooled NMR probe, at 45 °C 31P{1H} and 1H NMR spectroscopy showed a major resonance (~ 70%) corresponding to compound 7 at 53.56 ppm and a minor one corresponding to compound 8 (~30%) at 61.22 ppm. 1H NMR (toluene-d8, 500 MHz):  2.15 (septet, 4 H, J = 7.2 Hz) 1.33 (s, 36 H), 1.21 (dd, J = 15.5, 7.10 Hz, 12 H), 1.02 (m, 4 H), 0.95 (dd, J = 13.02, 7.1 Hz, 12 H), 11.01 (t, J = 11.4 Hz, 2 H, 9.5 Hz FWHM); 11B NMR (toluene-d8, 160 MHz):  38.8; 31P NMR (toluene-d8, 202 MHz):  53.56. Normalized % of intermediates    79  The probe was then cooled to 60 °C, and a 31P NMR spectrum was recorded. With selective decoupling of the aliphatic protons, the hydride coupling is preserved and the resulting triplet proves that two hydrides are bound to iridium in compound 7.  Generation of (dippe)Ir(H)3(Bpin)2 (8)  The J. Young tube from previous experiment which contained 7 (~ 70%) and 8 (~30%) was warmed up to 15 °C while the relative ratio of 8 to 7 was increasing, the rate of conversion was slow, therefore, the NMR tube was removed from the probe and shook for 10 seconds and placed back at 15 °C probe. 31P{1H}, 1H and 11B NMR showed compound 8 as the sole product (2% impurity from compound 9 was observed). 1H NMR (toluene-d8, 500 MHz):  1.96 (septet, 4 H, J = 7.2 Hz) 1.28 (s, 24 H), 1.11 (dd, J = 15.9, 7.1 Hz, 12 H), 1.02 (m, 4 H), 0.97 (s, 12 H), 0.89 (dd, J = 13.0, 7.1 Hz, 12 H), 11.21 (t, J = 5.5 Hz, 3 H); 11B NMR (toluene-d8, 160 MHz):  37.4; 31P{1H} NMR (toluene-d8, 202 MHz):  61.22. Single crystals of compound 8 were initially isolated from a pentane solution containing compounds 5, 6, and a 10-fold excess of HBpin. The reaction solution was placed in a 35 °C freezer to crystallize. After 1 week the crystals were analyzed and found to be compound 8. Generation of (dippe)Ir(H)4(Bpin) (9)  The J. Young NMR tube, containing compound 8 (from the previous experiment) was warmed to room temperature and 31P{1H} and 1H NMR spectra were recorded. A new signal appeared at 66.75 ppm in 31P NMR (compound 9); the ratio of compound 9 to compound 8 increased gradually. To facilitate the process the NMR tube was taken out of the NMR probe and shaken for 15 minutes at room temperature. 31P NMR, 1H NMR and  80  11B NMR confirmed formation of compound 9 in 97% purity (traces of compound 8 were present).  1H NMR (toluene-d8, 500 MHz):  1.73 (m, 4 H, J = 7.1 Hz) 1.15 (m, 4 H), 1.02 (dd, J = 15.3, 7.1 Hz, 12 H), 0.92 (dd, J = 13.7, 7.1 Hz, 12 H), 11.59 (t, J = 17.0 Hz, 4 H); 11B NMR (toluene-d8, 160 MHz):  37.5; 31P{1H} NMR (toluene-d8, 202 MHz)  66.75. When the 31P NMR spectrum is recorded with selective decoupling of the aliphatic protons, the hydride coupling is preserved and the resulting pentet proves that four hydrides are bound to iridium in compound 9. Single crystals of compound 9 were initially isolated from a pentane solution containing compounds 5, 6, 8, and a 10-fold excess of HBpin. The reaction mixture was placed in a 30 °C freezer to crystallize. After 2 weeks the crystals were analyzed and found to be 9. Synthesis of [(dippe)Ir(H)2(µH)]2 (10)  3.0 equiv of MeOH (0.075 mmol, 3.1 L) was injected to an NMR tube containing compound 9 via a syringe and 31PNMR, 1HNMR spectra were recorded. A new broad signal starts appearing in 31P NMR (compound 10). After 12 h, 31P{1H} and 1H NMR spectra showed a complex mixture containing ~ 90% of the desired compound. The NMR tube was taken in to the nitrogen filled glove box and solvent was removed under reduced pressure. The solid residue was then washed with pentane followed by recrystallization from mixture of toluene and pentane at 35 °C to yield compound 10 in 48% isolated yield (5.6 mg).  The crystalline solid was dissolved in toluene-d8 and VT NMR was obtained.  81  Room temperature 1H NMR: (toluene-d8, 500 MHz)  0.50-3.50 (broad features, 68 H), 3.64 (br, 2 H), 12.86 (br, 2 H), 22.56 (br, 2 H); 31P{1H} NMR (toluene-d8, 202 MHz)  77.25 (br), 75.87(br). Upon heating the J. Young NMR tube to 85 °C, a new peak appeared at  88.28 in the 31P{1H} 10 was fully converted to new species. (2-(diisopropylsilyl)phenyl)di-p-tolylphosphane (15)   (2-bromophenyl)di-p-tolylphosphine was synthesized on 10 mmol scale  reaction following a previously reported procedure in 95% (3.507 g) isolated yield (final work up was performed in air).4 (2-bromophenyl)di-p-tolylphosphine (3.507 g, 9.5 mmol) was added to a Schlenk flask containing a magnetic stir bar and kept under gentle stream of nitrogen through  the synthesis. Dry diethyl ether (50 mL) was added via syringe, and the flask was cooled to  78 oC. n-BuLi (4.0 mL, 10 mmol, 2.5 M) was added dropwise via syringe and the mixture was allowed to warm  to room temperature over 1 h. The reaction mixture was cooled back to  78 oC, and diisopropylchlorosilane (1.70 mL, 10.0 mmol) was added dropwise over 15 min. The resulting mixture was warmed to reach room temperature and stirred for 4 hours. In a nitrogen-filled glove box, the mixture was then filtered and the precipitate washed with toluene. Volatiles were removed from the filtrate under reduced pressure and the product was isolated as a white solid in 88% (3.840 g)  82  yield. 1H NMR (500 MHz, C6D6J = 7.4 Hz, 6H), 1.17 (d, J = 7.3 Hz, 6H), 1.47 (m, 2H), 1.98 (s, 6H), 4.57 (m, 1H), 6.90 (d, J = 7.8 Hz, 4H), 7.08-7.02 (m, 2H), 7.31 (d, J = 7.8 Hz, 4H), 7.36-7.33 (m, 1H), 7.62-7.58 (m, 1H); 13C NMR (125 MHz, C6D6) 12.1 (d, J = 6.7 Hz), 19.3 (d, J = 10.5 Hz), 21.2, 127.7, 129.1 (d, J = 6.7 Hz), 133.6 (d, J = 19.1 Hz), 134.0, 134.5 (d, J = 10.5 Hz), 136.7 (d, J = 15.3 Hz), 138.1, 142.9, 143.2, 144.3 (d, J = 10.4 Hz); 31P NMR (202 MHz, C6D6-9.82. (s). HRMS (ESI) m/z calcd for C26H34PSi [M + H]+ 405.2167, found 405.2159.  General procedure for ortho-directed borylation of methyl benzoates.  In a nitrogen filled glovebox, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol) was dissolved in 1 mL THF in a 15 mL pressure tube containing a magnetic stir bar. To the tube, 1 equiv. B2Pin2 (254.0 mg), 15 (0.0250 mmol, 10.0 mg), and 1.0 mmol methyl benzoate substrate were also added, and the reaction vessel was sealed and heated at 80 °C for 16h. The reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by passing it through a short plug of SiO2 eluting with MTBE. Additional purifications were performed as described below.   Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16a)  In a glove box, [Ir(OMe)(cod)]2 (3.3 mg, 0.0050 mmol), 15 (0.0100 mmol, 4.0 mg), and anhydrous, degassed THF (1.0 mL) were placed in a 15 mL pressure tube  83  containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Methylbenzoate (276.0 mg, 2.0 mmol) was added to the tube and lastly bis(pinacolato)diboron (254.0 mg, 1.0 mmol) was added as a solid, the reaction vessel was sealed and heated at 60 °C. Reaction progress was monitored by GC over 1 hour intervals. After 3 hours, (100% GC conversion based on B2pin2) the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by column chromatography; hexanes: EtOAc (12:1) to hexanes: EtOAc (9:1) as a pale yellow- oil (190.0 mg, 72% yield based on B2Pin2 (5% diborylated product, 16b, was observed in crude); 1H NMR (500 MHz, CDCl3J = 2.5, 8.4 Hz, 1H), 7.53-7.48 (m, 2H), 7.94 (d, J = 7.8 Hz, 1H). 5  Methyl 2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16b)  [Ir(OMe)(cod)]2 [Ir(OMe)(cod)]2 (16.6 mg, 0.0250 mmol), 0.5 equiv B2Pin2 (254.0 mg), 15 (0.0500 mmol, 20.0 mg). The product was obtained by recrystallization from MeOH/ H2O as a white solid (244.0 mg, 63% isolated yield); 1H NMR (500 MHz, CDCl3(s, 3H), 7.43 (d, J = 7.3 Hz, 1H), 7.70 (d, J = 7.4 Hz, 2H); 13C NMR (125 MHz, CDCl324.8, 52.0, 84.0, 128.9, 135.4, 141.7, 170.6; 11B NMR (160 MHz, CDCl3.0 (br s); HRMS (ESI) m/z calcd for C20H31B2O6 [M + H]+ 389.2307, found 389.2307.  84  Methyl 5-bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16c)  The reaction was performed using 0.5 mmol substrate (107.5 mg), [Ir(OMe)(cod)]2 (16.6 mg, 0.0250 mmol), 2 equiv B2Pin2 (254.0 mg), 15 (0.0500 mmol, 20.0 mg). Purified by column chromatography; hexanes: EtOAc (9:1). The product was obtained as yellow oil (139 mg, 60% yield (95% assay yield by 1H NMR); 1H NMR (500 MHz, CDCl31.40 (s, 12H), 3.91 (s, 3H), 7.37 (d, J = 7.8 Hz, 1H), 7.64 (dd, J = 2.0, 7.8 Hz, 1H), 8.07 (s, J = 1.5 Hz, 1H).6  Methyl 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16d)  The reaction was performed using 1.0 mmol substrate (166.0 mg), [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 1.25 equiv B2Pin2 (317.0 mg), 15 (0.0250 mmol, 10.0 mg). The product was obtained by recrystallization from MeOH/H2O as brown crystals (240.0 mg, 82% yield); 1H NMR (500 MHz, CDCl31.32 (s, 12H), 3.83 (s, 3H), 3.88 (s, 3H), 7.02 (d, J = 8.3 Hz, 1H), 7.32 (d, J =6.4 Hz, 1H), 7.38 (t, J = 7.3 Hz, 1H). 7       85  Methyl 5-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16e)  Purified by column chromatography; hexanes: EtOAc (9:1). The product was obtained as yellow oil (193.0 mg, 66% yield) Spectrum contains minor amounts of methyl 3-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate  1H NMR (500 MHz, CDCl3, 3.83 (s, 3H), 3.89 (s, 3H), 7.05 (dd, J =2.4, 8.3 Hz, 1H), 7.45-7.42 (m, 2H). 4  Methyl 3-methoxy-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16e´ )   Purified by column chromatography; hexanes: EtOAc (9: 1). The product was obtained as yellow powder (20.0 mg, 5% yield); 1H NMR (500 MHz, CDCl31.34 (s, 12H), 1.39 (s, 12H), 3.79 (s, 3H), 3.87 (s, 3H), 6.93 (d, J = 8.3 Hz, 1H), 7.50 (d, J = 7.9 Hz, 1H); 13C NMR (125 MHz, CDCl3169.3; 11B NMR (160 MHz, CDCl3 (br, s); HRMS (ESI) m/z calcd for C21H33B2O7 [M + H]+ 419.2420, found 419.2434.  86    Methyl 2,3-dimethoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16f)  The compound was obtained via recrystallization with MeOH/H2O as white crystals (227.0 mg, 70%  yield); 1H NMR (500 MHz, CDCl3) (s, 3H), 3.89 (s, 3H), 6.94 (d, J  =8.3 Hz, 1H), 7.51 (d, J = 7.8 Hz, 1H); 13C NMR (125 MHz, CDCl311B NMR (160 MHz, CDCl3.0 (br, s); HRMS (ESI) m/z calcd for C16H24BO6 [M + H]+ 323.1669, found 323.1677. Structure determination was done by single crystal X-ray diffraction studies.   Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)benzoate (6g)  The compound was obtained via recrystallization with MeOH/H2O, as black crystals (270.0 mg, 82% yield); 1H NMR (500 MHz, CDCl3, 3.92 (s, 3H), 7.55 (t, J = 7.8 Hz, 1H), 7.76 (d, J =8.3 Hz, 1H), 7.99 (d, J = 7.9, Hz, 1H). 7  87  Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzoate (16h)  The compound was obtained via recrystallization with MeOH/H2O, as brown powder (266.0 mg, 81% yield); 1H NMR (500 MHz, CDCl3(d, J = 7.8 Hz, 1H), 7.76 (dd, J = 1.0, 7.8 Hz, 1H), 8.19 (s, 1H).7  Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate (16i)  The compound purified by column chromatography; hexanes: EtOAc (9:1), and obtained as yellow oil (163.0 mg, 49% yield); 1H NMR (500 MHz, CDCl3 1.43 (s, 12H), 3.95 (s, 3H), 7.69 (dd, J = 7.8, 0.9 Hz, 1H), 7.74 (s, 1H), 8.04 (d, J = 8.3 Hz, 1H).7      88  Methyl 2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzoate (16i´ )  The compound purified by column chromatography; hexanes: EtOAc (9:1), and was obtained as brown crystals (77.0 mg, 17% yield); 1H NMR (500 MHz, CDCl3 1.34 (s, 24H), 3.89 (s, 3H), 7.93 (s, 2H); 13C NMR (125 MHz, CDCl324.7, 52.3, 84.5, 124.9 (J = 272.7 Hz), 130.7 (J = 32.4 Hz), 132.6 (J = 3.8 Hz), 145.9, 169.8; 19F NMR (470 MHz, CDCl3-62.8 (s); 11B NMR (160 MHz, CDCl3 (br, s); HRMS (ESI) m/z calcd for C21H30B2F3O6 [M + H]+ 457.2188, found 457.2198.  Methyl 5-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16j)  The compound purified by column chromatography; hexanes: EtOAc (9:1) and was obtained as yellow oil (227.0 mg, 82% yield); 1H NMR (500 MHz, CDCl3 1.42 (s, 12H), 2.38 (s, 3H), 3.91 (s, 3H), 7.34 (d, J = 7.4 Hz, 1H), 7.41 (d, J =7.3 Hz, 1H), 7.76 (s, 1H). 6   89  Methyl 4-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16k)  The product was obtained via column chromatography; hexanes: EtOAc (9:1), as white powder (135.0 mg, 49% yield); 1H NMR (500 MHz, CDCl3, 2.38 (s, 3H), 3.90 (s, 3H), 7.22 (dd, J = 1.0, 7.9 Hz, 1H), 7.29 (s, 1H), 7.85 (d, J = 7.8 Hz, 1H).6  Methyl 4-methyl-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16k´)  The product was obtained by column chromatography; hexanes: EtOAc (9:1), as brown crystals (54.0 mg, 13% yield);  1H NMR (500 MHz, CDCl3 1.36 (s, 24H), 2.35 (s, 3H), 3.87 (s, 3H), 7.45 (s, 2H); 13C NMR (125 MHz, CDCl351.9, 83.9, 135.4, 137.7, 139.3, 170.3; 11B NMR (160 MHz, CDCl3.0 (br, s); HRMS (ESI) m/z calcd for C21H33B2O6 [M + H]+ 403.2471, found 403.2462.      90  Reaction optimization for catalyst loading, temperature and time  In a glove box, [Ir(OMe)(cod)]2 (3.3 mg, 0.0050 mmol), 15 (0.0100 mmol, 4.0 mg), and anhydrous, degassed THF (1.0 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Methyl 4-methylbenzoate (150.2 mg, 1.0 mmol) was added to the tube and lastly bis(pinacolato)diboron (254.0 mg, 1.0 mmol) was added as solid, the reaction vessel was sealed and heated at 60 °C. Reaction progress was monitored by GC over 1 hour intervals. After 3 hours, (100% GC conversion based on B2pin2) the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by column chromatography; hexanes: EtOAc (9:1). 16K and 16K´ were obtained in 55% (152.0 mg) and 10% (41.2 mg) isolated yield.  Methyl 2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16l)  Product was purified by column chromatography; hexanes: EtOAc (9:1) as yellow oil (281.0 mg, 84% yield); 1H NMR (500 MHz, CDCl3 1.36 (s, 12H), 3.92 (s, 3H), 7.16 (m, 1H), 7.46 (m, 2H); 13C NMR (125 MHz, DMSO-d624.9, 53.0, 84.6, 118.8 (J = 21.0 Hz), 124.9 (J = 13.3 Hz), 130.1 (J = 3.8 Hz), 133.2 (J = 8.6 Hz), 160.3 (J = 251.8 Hz), 166.1; 19F NMR 470 MHz, CDCl3115.0 (s); 11B NMR (160 MHz, CDCl3) 31.0 (br, s); HRMS (ESI) m/z calcd for C14H19BFO4 [M + H]+ 281.1363, found 281.1371.  91  tert-Butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16m)  In a glove box, [Ir(OMe)(cod)]2 (3.3 mg, 0.0050 mmol), 15 (0.0100 mmol, 4.0 mg), and anhydrous, degassed THF (1.0 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. tert-Butyl benzoate (178.2 mg, 1.0 mmol) was added to the tube and lastly bis(pinacolato)diboron (254.0 mg, 1.0 mmol) was added as solid, the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 2 hour intervals. After 16 hours, (80% GC conversion based on B2pin2) the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by column chromatography; hexanes: Et2O (4:1) as a white solid (192.0 mg, 63% yield). No diborylated product was observed in crude; 1H NMR (500 MHz, CDCl3-7.49 (m, 2H), 7.82 (d, J = 7.8 Hz, 1H). 7  Methyl 4-bromo-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16n)   92  The reaction was performed using 1.0 mmol substrate (233.0 mg), [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 1 equiv B2pin2 (254.0 mg), 4,4´-di-tert-butyl bipyridine (6.7 mg, 0.0250 mmol), 1 mL hexanes.  Product was obtained via recrystallization with MeOH/H2O as a pale white powder (370 mg, 80% yield) Spectrum contains minor amounts of 4-bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 1H NMR (500 MHz, CDCl3, 3.97 (s, 3H), 7.40 (d, J = 10.3 Hz, 1H), 8.23 (d, J = 8.3 Hz, 1H), Aromatic couplings are due to H-F couplings; 13C NMR (125 MHz, CDCl3 24.8 (J = 10.5 Hz), 52.4, 84.6,  117.1 (J = 8.6 Hz),  121.8 (J = 24.8 Hz), 133.7 (J = 9.5 Hz), 140.2 (J = 1.9 Hz), 163.6 (J = 268), 164.2; 19F NMR 470 MHz, CDCl3104.6 (s); 11B NMR (160 MHz, CDCl3.0 (br, s); HRMS (ESI) m/z calcd for C13H14BBrFO4 3 + H]+ 343.0155, found 343.0160.  Methyl 4-bromo-2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (16o)  Purified by column chromatography; hexanes: EtOAc (8.5: 1). Yellow Oil (255.0 mg, 70% yield); 1H NMR (500 MHz, CDCl3 1.38 (s, J=0.9 Hz, 12H), 3.93 (s, J = 1.5 Hz, 3H), 7.35 (d, J= 9.3 Hz, 1H), 7.53 (s, 1H);  13C NMR (125 MHz, CDCl324.7, 52.8, 84.6, 121.4 (J = 24.8 Hz),  122.7 (J = 12.4 Hz), 126.1 (J = 8.6 Hz), 132.0 (J = 3.8 Hz), 160.9 (J = 261.3 Hz), 166.2; 19F NMR (470 MHz, CDCl3-109.7 (s); 11B NMR (160  93  MHz, CDCl3.0 (br, s); HRMS (ESI) m/z calcd for C13H14BBrFO4 3 + H]+ 343.0155, found 343.0150.  N,N-Dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (18a)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1 mmol) and anhydrous, degassed THF (4.5 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. N,N-Dimethyl benzamide (149.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 4 hour intervals. After 16 hours, (86% GC conversion) the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by passing it through a short plug of SiO2 eluting (hexane/EtOAc = 1/1). The product was isolated by precipitation from hexane. White solid (206.2 mg) in 75% isolated yield. 1H NMR (500 MHz, CDCl3 s, 6H), 7.30 (dd, J = 7.5, 0.6 Hz, 1H), 7.37 (dt, J = 7.5, 1.5 Hz, 1H), 7.45 (dt, J = 7.5, 1.5 Hz, 1H), 7.80 (dd, J = 7.5, 0.6 Hz, 1H).7  94  4-chloro-N,N-dimethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (18b)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron  (254.0 mg, 1.0 mmol) and anhydrous, degassed THF (4.5 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. 4-Chloro N,N-dimethyl benzamide (183.6 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 4 hour intervals. After 16 hours, 95% conversion was observed. The reaction was stopped and mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by passing it through a short plug of SiO2 eluting with (hexane/EtOAc = 1/1). The product was isolated by precipitation from hexane. White solid (263.1 mg) in 85% isolated yield was obtained. 1H NMR (500 MHz, CDCl3J=8.3, 1 H) 7.40 (d, J=8.3 Hz, 1 H) 7.76 (s, 1 H); 13C NMR (125 MHz, CDCl3127.1, 130.6, 134.5, 135.1, 139.7, 171.5; 11B NMR (160 MHz, CDCl3HRMS (ESI) m/z calcd for C15H22BClNO3 [M + H]+ 310.1384, found 310.1386.   95  Methyl 4-(dimethylcarbamoyl)-2,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (18c)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (508.0 mg, 2 mmol) and anhydrous, degassed THF (4.5 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Methyl 4-(dimethylcarbamoyl)benzoate (207.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 100 °C. Reaction progress was monitored by GC over 4 h intervals. After 16 hours the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by passing it through a short plug of SiO2 eluting with (hexane/EtOAc = 1/1). The product was isolated by precipitation from hexane. White solid (436.0 mg) in 95% isolated yield. 1H NMR (500 MHz, CDCl3(br. s., 3 H) 3.93 (s, 3 H) 7.42 (s, 1 H) 8.37 (s, 1 H); 13C NMR (125 MHz, CDCl3 24.8, 24.9, 52.4, 84.0, 84.2, 129.5, 132.8, 135.3, 146.0, 168.0, 171.7; 11B NMR (160 MHz, CDCl30.2 (s); HRMS (ESI) m/z calcd for C23H36B2NO7 [M + H]+ 460.2686, found 460.2684.   96  2-(2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (18d)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1 mmol) and anhydrous, degassed THF (3 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Anisole (108.0 mg, 1.0 mmol) was added to the tube; the reaction vessel was sealed and heated at 100 °C. Reaction progress was monitored by GC over 4 hour intervals. After 12 hours all of bis(pinacolato)diboron was consumed and no further conversion was observed, the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was characterized as mixture of 6:1:2 (ortho: meta+para: diborylation) with 55% total GC conversion, (for better clarity of isomeric ratio on 1HNMR of crude material, some starting material was removed under vacuum).8  2-(2-methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (18e)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1 mmol) and anhydrous degassed THF (3 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. 3-Methyl anisole (122.0 mg, 1.0 mmol) was added  97  to the tube; the reaction vessel was sealed and heated at 100 °C. Reaction progress was monitored by GC over 4 hour intervals. After 12 hours, all bis(pinacolato)diboron was consumed and 46% GC conversion based on substrate and no further was observed (crude mixture contained 7% of the meta isomer). The reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and product was purified by Kugelrohr distillation. The product was isolated as white solid (86.0 mg) in 35 % isolated yield. 1H NMR (500 MHz, CDCl36.74 (d, J=7.4 Hz, 1 H) 7.55 (d, J=7.5 Hz, 1 H).9  Ethyl 4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (18f)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed n-hexane (1 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Ethyl 4-methoxybenzoate (180.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C, and reaction progress was monitored by GC. After 12 hours 90% conversion was observed and reaction mixture was allowed to return to room temperature and was exposed to air. Purification with column chromatography (gradient from hexane/EtOAc = 9/1 to  98  hexane/EtOAc = 4/1) resulted in ethyl 4-methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (226.0 mg) as oil with 77% isolated yield. (5% conversion to ethyl 4-methoxy-2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate was observed by 1HNMR of the crude reaction mixture and by GC). 1H NMR (500 MHz, CDCl3J=7.1 Hz, 3H) 1.43 (s, 12 H) 3.86 (s, 3 H) 4.36 (q, J=7.3 Hz, 2 H) 6.88 (dd, J=8.8, 2.5 Hz, 1 H) 6.95 (d, J=2.5 Hz, 1 H) 7.91 (d, J=8.8 Hz, 1 H); 13C NMR (125 MHz, CDCl39, 55.4, 60.9, 84.0, 114.1, 116.8, 126.0, 130.7, 162.4, 167.7; 11B NMR (160 MHz, CDCl3C16H24BO5 [M + H]+ 307.1720, found 307.1726.  N-Methoxy-N-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (18g)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed THF (4.5 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. N-Methoxy-N-methylbenzamide (165.0 mg, 1.0 mmol) was added to the tube; the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 4 hour intervals. After 12 hours the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by  99  silica column chromatography (gradient from CHCl3 to 2% MeOH: 98% CHCl3. Colorless viscose oil (244.4 mg) was obtained in 84% isolated yield. 1H NMR (500 MHz, CDCl3- 7.46 (m, 2 H) 7.49 - 7.55 (m, 1 H) 7.72 - 7.77 (m, 1 H); 13C NMR (125 MHz, CDCl3ppm 25.0, 34.03, 61.0, 83.32, 126.5, 128.0, 128.1, 128.7, 129.5, 130.03, 130.6, 132.2, 133.6 (br); (Presumably, due to interaction of NOMe group with pinacol group some peaks in 1HNMR and 13CNMR are broad). 11B NMR (160 MHz, CDCl3(br,s) ; HRMS (ESI) m/z calcd for C15H23BNO4 [M + H]+ 292.1723, found 292.1728.  Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate (18h)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed n-hexane (2 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Thiophene-2-carboxylic acid methyl ester (142.0 mg, 1.0 mmol) was added to the tube; the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 1 h interval. After 1h, the reaction mixture was allowed to return to room temperature and was exposed to air. 85% GC conversion was observed (ratio 3 position: 5 position: diborylated: 14:1:1). The volatiles were then removed under reduced pressure and Kugelrohr distillation resulted in a white solid  100  (174.2 mg) in 65% isolated yield. 1H NMR (500 MHz, CDCl39 (s, 3H), 7.19 (d, J = 4.9 Hz, 1H), 7.5 (d, J = 4.9 Hz, 1H).10  Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthoate (18i)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.025 mmol, 10.0 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed n-hexane (1 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Methyl 1-naphthoate (186.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C, Reaction progress was monitored by GC. After 8h full conversion was observed and the reaction mixture was allowed to return to room temperature and was exposed to air. Purification with column chromatography (dichloromehane) resulted in colorless oil (265.0 mg) in 85% isolated yield. 1H NMR (500 MHz, CDCl37.50 - 7.58 (m, 2 H), 7.78 (d, J=8.3 Hz, 1 H) 7.83 - 7.89 (m, 1 H) 7.9 (d, J=8.3 Hz, 1 H) 8.1 (d, J=8.3 Hz, 1 H); 13C NMR (125 MHz, CDCl3, 52.4, 84.2, 125.5, 127.0, 127.0, 128.1, 129.4, 129.5, 134.4, 137.0, 170.5; 1H NMR (500 MHz, C6D63.77 (s, 3 H) 7.17 - 7.21 (m, 1 H) 7.25 (ddd, J=8.3, 6.9, 1.5 Hz, 1 H) 7.51 (d, J=8.3 Hz, 1 H) 7.59 (d, J=7.8 Hz, 1 H) 8.01 (d, J=8.3 Hz, 1 H) 8.35 (d, J=8.3 Hz, 1 H); 13C NMR (125 MHz C6D624.5, 51.6, 83.7, 125.7, 126.8, 126.9, 128.1, 129.1, 129.8, 129.9, 134.7, 138.4, 169.7; 11B NMR (160 MHz, CDCl3 (s); HRMS (ESI) m/z calcd for C18H22BO4 [M + H]+ 313.1614, found 313.1612.  101  2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine (18j)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron  (254.0 mg, 1.0 mmol) and anhydrous, degassed THF (2 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. 2-Phenyl pyridine (202.0 mg, 1.3 mmol) was added to the tube, the reaction vessel was sealed and heated at 60 °C, and reaction progress was monitored by GC. After 2h the reaction mixture was allowed to return to room temperature and was exposed to air. After removal of solvent, purification using silica column chromatography (hexane/EtOAc = 1/3) resulted in a white solid (182 mg) 65% isolated yield. (15% of diborylated material was observed in crude reaction mixture by GC, which was characterized as 18j´ by independent synthesis, see below). 1H NMR (500 MHz, CDCl37.44 (m, 3H), 7.68 (d, J = 7.8 Hz, 1H), 7.75 (d, J = 7.3 Hz, 1H), 7.83 (d, J = 8.3 Hz, 1H), 7.99 (td, J = 7.8, 1.5 Hz, 1H), 8.70 (d, J = 5.4 Hz, 1H).11 2-(2,6-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine (18j´ )  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron 508.0 mg, 2.0 mmol) and anhydrous, degassed THF (2 mL) were  102  placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. 2-phenyl pyridine (155.2 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 60 °C, and reaction progress was monitored by GC. After 24 hours the reaction mixture was allowed to return to room temperature and was exposed to air. Solvent was removed under reduced pressure. Upon addition of hexane to the mixture white solid precipitate. White solid (264.4 mg) with 65 % isolated yield (15% of monoborylated material was observed in GC of crude reaction mixture). 1H NMR (500 MHz, CDCl3 1.42 (s, 24 H) 7.37 (m, 2 H) 7.79 (d, J=7.34 Hz, 2 H) 7.91 - 7.96 (t, J=7.83 Hz, 1 H) 8.68 (d, J=5.4 Hz, 1 H) 8.81 (d, J=7.8 Hz, 1 H); 13C NMR (125 MHz, CDCl3157.7; 11B NMR (160 MHz, CDCl3C23H32B2NO4 [M + H]+ 408.2517, found 408.2526  Borylation of Chlorobenzene In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 15 (0.0250 mmol, 10.0 mg), bis(pinacolato)diboron (127.0 mg, 0.5 mmol) and anhydrous, degassed THF (1 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Chlorobenzene (56.0 mg, 0.5 mmol) was added to the tube; the reaction vessel was sealed and heated at 80 °C. The reaction was stopped after 16 hours, and the mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was characterized as mixture of isomers, with ortho: (meta+para) being 1:3 after 55% conversion.  103  IrCODSiPBz (19) In a nitrogen filled glove box, [Ir(OMe)(cod)]2 (100.0 mg, 0.151 mmol) was fully dissolved in a minimum amount of n-hexane (30 mL) in a 100 mL flask, 15 ( 121.0 mg, 0.302 mmol) was added to the flask as a solid. Upon addition of SiPBz, the solution turned a deep red color. After 15 minutes, 31PNMR showed full consumption of free phosphine. Then the solvent was fully removed under vacuum and the crude was dissolved in a minimal amount of pentane and stored in a -30 °C freezer. Dark red crystals were obtained after 2 days (100.1 mg, 47% isolated yield). Structure determination was made by single crystal X-ray diffraction studies. 1H NMR (500 MHz, C4D8O,d8-THFJ=7.4 Hz, 6 H), 1.02 (d, J=7.4 Hz, 6 H), 1.55 - 1.63 (m, 2 H) ,1.63 - 1.70 (m, 2 H), 1.75 - 1.85 (m, 2 H), 1.97 - 2.07 (m, 2 H), 2.07 - 2.18 (m, 2 H), 2.26 - 2.40 (s, 6 H), 3.77 (m, 2 H), 5.38 (m, 2 H), 7.10 - 7.23 (m, 5 H), 7.28 (td, J=7.24, 1.77 Hz, 1 H), 7.38 - 7.53 (m, 5 H), 7.71 (d, J=7.1 Hz, 1 H); 13C NMR (125 MHz, C4D8O,d8-THF19.7, 21.2 (d, J=2.8 Hz), 21.5 (d, J=2.3 Hz), 30.3 (d, J=2.9 Hz), 34.3 (d, J=2.9 Hz), 77.7 (d, J=12.4 Hz), 81.3, 129.2, 129.3, 129.76, 129.84, 130.1, 132.3 (d, J=5.7 Hz), 133.6, 133.9, 134.2, 134.3, 135.2 (d, J=22.7 Hz ),140.69, 140.71, 148.6 , 157.2, 157.6; 31P NMR (202 MHz, C4D8O,d8-THF)  8-(diisopropylsilyl)quinolone (QSi) (20)  sec-Butyllithium (1.3 M in cyclohexane, 7.25 mL, 9.45 mmol) was added dropwise via syringe to a magnetically stirred solution of 8-bromoquinoline (1.955 g, 9.4 mmol) in  104  35.00 mL of Tetrahydrofuran at -78°C over 5 min, followed by stirring for an additional 15 min at this temperature. Diisopropylchlorosilane (1.59 mL, 9.3 mmol), was then added dropwise via syringe over 10 min, and the resulting mixture was allowed to warm to ambient temperature over 2 h. After removal of the solvent and volatiles, the crude mixture was subjected to silica column using hexane. Product was obtained as colorless liquid (1.970 g), in 87% yield. 1H NMR (500 MHz, C6D6)  ppm 1.14 (d, J=7.3 Hz, 6 H), 1.30 (d, J=7.3 Hz, 6 H) 1.82 (m, 2 H) 4.50 (t, J=3.9 Hz, 1 H) 6.75 (dd, J=8.3, 3.9 Hz, 1 H) 7.23 (dd, J=8.1, 6.6 Hz, 1 H) 7.42 (dd, J=8.3, 1.5 Hz, 1 H) 7.52 (dd, J=8.3, 2.0 Hz, 1 H) 8.02 (dd, J=6.8, 1.5 Hz, 1 H) 8.67 (dd, J=4.4, 2.0 Hz, 1 H);  13C NMR (125 MHz, C6D6ppm 12.7, 20.17, 20.22, 121.3, 126.7, 129.9, 136.4, 138.9, 139.7, 149.9, 153.4; HRMS (ESI) m/z calcd for C15H22NSi [M + H]+ 244.1521, found 244.1527. 5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl dimethylcarbamate (22a)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 20 (0.0250 mmol, 6.1 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed THF (1 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. 3-Chlorophenyl dimethylcarbamate (200.0 mg, 1.0 mmol) was added to the tube; the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC. After 4h, 93% conversion was observed and the reaction mixture was allowed to return to room temperature and was exposed to air.  105  Purification with column chromatography (gradient from dichloromethane to dichloromethane/EtOAc, 98/2) resulted in pale yellow oil (195.0 mg) with 60% isolated yield. 1H NMR (500 MHz, CDCl3J=1.5 Hz, 1 H) 7.18 (dd, J=7.8, 2.0 Hz, 1 H) 7.69 (d, J=8.3 Hz, 1 H); 13C NMR (125 MHz, CDCl311B NMR (160 MHz, CDCl3.0 (br, s); HRMS (ESI) m/z calcd for C15H22BClNO4 [M + H]+ 326.1333 found 326.1324.  Method B The reaction was performed using 0.5 mmol substrate (99.5 mg), [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 2 equiv B2pin2 (254.0 mg), 15 (0.0250 mmol, 10.0 mg) (5.0 mol %), 1.5 ml THF. Purified by column chromatography; hexanes: EtOAc (8.5:1) using Alizarin as an indicator. The compound was isolated as a clear gel (26.0 mg, 12 % yield). 1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-1-one (22b)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 20 (0.0250 mmol, 6.1 mg), bis(pinacolato)diboron (254.0 mg, 1 mmol) and anhydrous, degassed THF (1 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. propiophenone (134.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C. Reaction progress was  106  monitored by GC. After 1h the reaction mixture was allowed to return to room temperature and was exposed to air (82% GC conversion). Purification with column chromatography (hexane/EtOAc) resulted in a white solid (182.2 mg) with 70% isolated yield (NMR shows 3% starting material). 1H NMR (500 MHz, CDCl3J=7.3 Hz, 3 H) 1.45 (s, 12 H) 3.01 (q, J=7.3 Hz, 2 H) 7.43 (ddd, J=7.9, 5.3, 2.9 Hz, 1 H) 7.52 - 7.55 (m, 2 H) 7.82 (d, J=7.8 Hz, 1 H).12 Borylation of anisole using 20  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 20 (0.0250 mmol, 6.1 mg), and anhydrous, degassed THF (3 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. Anisole (108.0 mg, 1.0 mmol) was added to the tube and lastly, bis(pinacolato)diboron (254.0 mg, 1.0 mmol) was added as a solid; the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 4 hour intervals. After 12 hours no further conversion was observed, the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was characterized as mixture of 1.6:4.2:1.0 (ortho: meta+para: diborylation) with 40% total GC conversion. Borylation of tert-Butyl benzoate using (20)   107  In a glove box, [Ir(OMe)(cod)]2 (3.3 mg, 0.0050 mmol), 20 (0.0100 mmol, 3.0 mg), and anhydrous, degassed THF (1.0 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. tert-Butyl benzoate (178.2 mg, 1.0 mmol) was added to the tube and lastly bis(pinacolato)diboron (254.0 mg, 1.0 mmol) was added as a solid, the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 1 hour intervals. After 3 hours, (91% GC conversion based on benzoate) the reaction mixture was allowed to return to room temperature and was exposed to air. The volatiles were then removed under reduced pressure and the product was purified by column chromatography; hexanes: Et2O (4:1) to afford a white solid (238.0 mg, 78% yield). No diborylated product was observed in the crude reaction; 1H NMR was identical to the previous report.7  Borylation of N,N-dimethylbenzamide using (20)  In a glove box, [Ir(OMe)(cod)]2 (8.3 mg, 0.0125 mmol), 20 (0.0250 mmol, 6.1 mg), bis(pinacolato)diboron (254.0 mg, 1.0 mmol) and anhydrous, degassed THF (4.5 mL) were placed in a 15 mL pressure tube containing a magnetic stir bar, and the mixture was stirred for 1 min at room temperature. N,N-Dimethyl benzamide (149.0 mg, 1.0 mmol) was added to the tube, the reaction vessel was sealed and heated at 80 °C. Reaction progress was monitored by GC over 1 hour intervals. After 4 hours, (90% GC conversion) the reaction mixture was allowed to return to room temperature and was  108  exposed to air. The volatiles were then removed under reduced pressure and the product was purified by passing it through a short plug of SiO2 eluting (hexane/EtOAc = 1/1). The product was isolated by precipitation from hexane. A white solid (220.2 mg) was isolated in 80% yield. 1H NMR was identical to the previous report.7 Borylation of benzamides (17a and 18a) and benzoates (17f and tert-butyl benzoate) using (20) vs (15) Reactions were performed under identical conditions as described for analogues reaction using (15).   109  Table 5. Comparing reactivity of  Ir-catalyzed CHB using ligand 15 and 20   110            REFERENCES  111  REFERENCES  1. Chotana, G. A.; Vanchura, B. A., II; Tse, M. K.; Staples, R. J.; Maleczka, R. E., Jr.; Smith, M. R., III Chem. Commun. 2009, 5731.  2. Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. 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Lett. 2011, 40, 1007.  113            APPENDICES  114  APPENDIX A, NMR Spectra  Figure A 1. 31P{1H} NMR of reaction intermediates for catalytic borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin in cyclohexane-d12  180 min 160 min 140 min 120 min 100 min 80 min 60 min 40 min 20 min  115   Figure A 2. 31P{1H} NMR spectra in cyclohexane-d12  at the end of catalytic borylation run of 2-methylthiophene with 0.5 equivalents of  HBpin, mainly shows compound 10   116   Figure A 3. 1H NMR spectra of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10  117   Figure A 4. gCOSY spectrum of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10    118   Figure A 5. 1H31P HMQC spectrum of hydride region in cyclohexane-d12  at the end of catalytic run of 2-methylthiophene with 0.5 equivalents of HBpin, mainly shows compound 10    119   Figure A 6. 31P{1H} NMR of reaction intermediates for early stage of catalytic conversion of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin  0 min 5 min 10 min 15 min 20 min 6 7 8 8 9 9 8 6 7  120   Figure A 7. Hydride region in 1H NMR spectra of reaction intermediates for early stage of catalytic borylation of 2-methylthiophene with compound 5, using 0.5 equivalents of HBpin in toluene-d8.    20 min 15 min 10 min 5 min 0 min 9 9 8 8 8 8 7 7 6 6  121    Figure A 8. 31P NMR spectrum with selective decoupling of aliphatic protons for compound 7 at -45 °C, (J= 9.9 Hz)  122   Figure A 9. 31P NMR spectrum with selective decoupling of aliphatic protons for compound 9 (J= 18.3 Hz)      9  123   Figure A 10. 31P{1H} NMR of reaction of H2 with compound 5. 1) Initial spectrum at -45 °C, 2) At -15 °C after 10 sec of shaking the tube, 3) At rt after 15 minutes of shaking the tube  7 8 8 9 1) 2) 3)  124   Figure A 11. Hydride region in 1H NMR spectra of reaction of H2 with compound 5 1) Initial 1HNMR at -45 °C, 2) At -15 °C after 10 sec of shaking the tube, 3) At rt after 15 minutes of shaking the mixture           9 8 8 7 1) 2) 3)  125   Figure A 12. Hydride region in 1H NMR spectra of compound 10 in toluene d-8  at different temperatures   126   Figure A 13. 31P{1H} NMR spectra of compound 10 in toluene d-8  at different temperatures    Figure A 14. 1H NMR spectra of thermolysis of compound 10, in toluene d-8  at different temperatures -65 °C 25 °C -100 °C  127    Figure A 15. 31P{1H} NMR spectra of thermolysis of compound 10, in toluene d-8  at different temperatures  -65 °C 25 °C -100 °C  128   Figure A 16. 1H NMR of compound 15  129   Figure A 17. 13C NMR of compound 15  130   Figure A 18. 31P NMR of compound 15  131   Figure A 19. 1H NMR of compound 16b  132   Figure A 20. 13C NMR of compound 16b  133   Figure A 21. 1H NMR of compound 16e'  134   Figure A 22. 13C NMR of compound 16e'  135   Figure A 23. 1H NMR of compound 16f  136   Figure A 24. 13C NMR of compound 16f  137   Figure A 25. 1H NMR of compound 16i  138   Figure A 26. 13C NMR of compound 16i  139   Figure A 27. 19F NMR of compound 16i  140   Figure A 28. 1H NMR of compound 16k'  141   Figure A 29. 1H NMR of compound 16k'  142   Figure A 30. 1H NMR of compound 16l  143   Figure A 31. 13C NMR of compound 16l  144   Figure A 32 19F NMR of compound 16l  145   Figure A 33. 1H NMR of compound 16n  146   Figure A 34. 13C NMR of compound 16n  147   Figure A 35. 1H NMR of compound 16o  148   Figure A 36. 13C NMR of compound 16o  149   Figure A 37. 19F NMR of compound 16o  150   Figure A 38. 1H NMR of compound 18a  151   Figure A 39. 13C NMR of compound 18a  152   Figure A 40. 1H NMR of compound 18c  153   Figure A 41. 13C NMR of compound 18c  154   Figure A 42. 1H NMR of compound 18d  155   Figure A 43. 1H NMR of compound 18f  156   Figure A 44. 13C NMR of compound 18f  157   Figure A 45. 1H NMR of compound 18g  158   Figure A 46. 13C NMR of compound 18g  159   Figure A 47. 1H NMR of compound 18i  160   Figure A 48. 13C NMR of compound 18i  161   Figure A 49. gCOSY NMR of compound 18i  162   Figure A 50. Expansion of gCOSY NMR of compound 18i  163   Figure A 51. 1H NMR of compound 18j'  164   Figure A 52. 13C NMR of compound 18j'  165   Figure A 53. gCOSY NMR of compound 18j'  166   Figure A 54. Expansion of gCOSY NMR of compound 18j'  167   Figure A 55. 1H NMR of compound 19  168   Figure A 56. 13C NMR of compound 19  169   Figure A 57. 31P NMR of compound 19  170   Figure A 58. 1H NMR of compound 20  171   Figure A 59. 1H NMR of compound 20  172   Figure A 60. 1H NMR of compound 22a   173  APPENDIX B, Crystal Data and Structure Crystal data and structure refinement for 6·(CF3)2C6H4. Identification code  (dippe)IrH(BPin)2(=BPinBPin) Empirical formula  C46 H85 B4 F6 Ir O8 P2 Formula weight  1177.52 Temperature  173(2) K Wavelength  0.71073 Å Crystal system  Monoclinic Space group  P2(1)/n Unit cell dimensions a = 12.6467(15) Å  = 90°.  b = 11.3423(13) Å  = 93.481(2)°.  c = 39.579(5) Å  = 90°. Volume 5666.9(11) Å3 Z 4 Density (calculated) 1.380 Mg/m3 Absorption coefficient 2.477 mm-1 F(000) 2424 Crystal size 0.035 x 0.013 x 0.003 mm3 Theta range for data collection 1.66 to 29.20°. Index ranges -16<=h<=17, -15<=k<=15, -52<=l<=51 Reflections collected 67440 Independent reflections 14253 [R(int) = 0.1050] Completeness to theta = 25.00° 100.0 %  Absorption correction Semi-empirical from equivalents Max. and min. transmission 1.00 and 0.8286 Refinement method Full-matrix least-squares on F2 Data / restraints / parameters 14253 / 354 / 697 Goodness-of-fit on F2 1.074 Final R indices [I>2sigma(I)] R1 = 0.0587, wR2 = 0.1184 R indices (all data) R1 = 0.1192, wR2 = 0.1411 Largest diff. peak and hole 1.457 and -1.949 e.Å-3   174  Crystal data and structure refinement for 8. Identification code  (dippe)Ir(H)3(BPin)2 Empirical formula  C26 H59 B2 Ir O4 P2 Formula weight  711.49 Temperature  173(2) K Wavelength  0.71073 Å Crystal system  Triclinic Space group  P-1 Unit cell dimensions a = 11.6009(5) Å  = 100.827(3)°.  b = 14.7110(7) Å  = 92.604(3)°.  c = 20.1115(11) Å  = 96.944(3)°. Volume 3338.2(3) Å3 Z 4 Density (calculated) 1.416 Mg/m3 Absorption coefficient 4.122 mm-1 F(000) 1456 Crystal size 0.450 x 0.252 x 0.17 mm3 Theta range for data collection 1.59 to 27.13°. Index ranges -14<=h<=14, -18<=k<=18, -25<=l<=25 Reflections collected 53994 Independent reflections 14567 [R(int) = 0.0238] Completeness to theta = 25.00° 99.6 %  Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.7455 and 0.5592 Refinement method Full-matrix least-squares on F2 Data / restraints / parameters 14567 / 0 / 1103 Goodness-of-fit on F2 1.081 Final R indices [I>2sigma(I)] R1 = 0.0187, wR2 = 0.0422 R indices (all data) R1 = 0.0242, wR2 = 0.0440 Largest diff. peak and hole 0.941 and -0.454 e.Å-3  175  Crystal data and structure refinement for 9.  Identification code  (dippe)Ir(H)4(BPin) Empirical formula  C20 H48 B Ir O2 P2 Formula weight  585.53 Temperature  173(2) K Wavelength  0.71073 Å Crystal system  Monoclinic Space group  P2(1)/n Unit cell dimensions a = 14.309(2) Å  = 90°.  b = 10.9786(16) Å  = 93.976(2)°.  c = 16.258(2) Å  = 90°. Volume 2547.8(6) Å3 Z 4 Density (calculated) 1.526 Mg/m3 Absorption coefficient 5.377 mm-1 F(000) 1184 Crystal size 0.23 x 0.16 x 0.06 mm3 Theta range for data collection 1.83 to 28.11°. Index ranges -18<=h<=17, -13<=k<=13, -20<=l<=20 Reflections collected 19742 Independent reflections 5676 [R(int) = 0.0256] Completeness to theta = 25.00° 99.8 %  Absorption correction Semi-empirical from equivalents Max. and min. transmission 0.7385 and 0.3710 Refinement method Full-matrix least-squares on F2 Data / restraints / parameters 5676 / 0 / 427 Goodness-of-fit on F2 0.989 Final R indices [I>2sigma(I)] R1 = 0.0191, wR2 = 0.0400 R indices (all data) R1 = 0.0304, wR2 = 0.0436 Largest diff. peak and hole 0.647 and -0.875 e.Å-3        176  Crystal data and structure refinement for 10.     Empirical formula                           C28H70Ir2P4  Formula weight  915.12  Temperature/K  173.15  Crystal system  monoclinic  Space group  P21/c  a/Å  10.2844(8)  b/Å  14.0396(10)  c/Å  12.9636(10)   90   108.7800(10)   90  Volume/Å3  1772.1(2)  Z  2  calcg/cm3  1.715  -1  7.698  F(000)  904.0  Crystal size/mm3  0.138 × 0.084 × 0.043  Radiation    4.184 to 50.728  Index ranges  --- Reflections collected  14563  Independent reflections  3249 [Rint = 0.0386, Rsigma = 0.0327]   Data/restraints/parameters   3249/0/162  Goodness-of-fit on F2  1.054   R1 = 0.0315, wR2 =0.0762  Final R indexes [all data]  R1 = 0.0414, wR2 =0.0815            177  Crystal data and structure refinement for 19.  Empirical formula  C34H44IrPSi  Formula weight  703.95  Temperature/K  173.15  Crystal system  triclinic  Space group  P-1  a/Å  9.9128(11)  b/Å  10.2416(11)  c/Å  16.4821(18)   77.3150(10)   86.7650(10)   69.1190(10)  Volume/Å3  1524.8(3)  Z  2  calcmg/mm3  1.533  m/mm-1  4.491  F(000)  708.0  Crystal size/mm3  0.10 × 0.092 × 0.073  Radiation    4.358 to 50.38°  Index ranges  --- Reflections collected  28194  Independent reflections  5481[R(int) = 0.0621]  Data/restraints/parameters  5481/48/340  Goodness-of-fit on F2  1.060   R1 = 0.0395, wR2 = 0.0819  Final R indexes [all data]  R1 = 0.0519, wR2 = 0.0884  Largest diff. peak/hole / e Å-3  1.19/-0.95    178  APPENDIX C, Computational Results Calculated coordinates for (dmpe)Ir(H)(Bpin)2(=BOCMe2CMe2OBpin) C     4.352864    -3.165203    -0.985134  P     3.196543    -1.995913    -1.791029  C     4.254386    -1.312454    -3.165059  C     3.654219    -0.036103    -3.747299  P     3.196312     1.135964    -2.375665  C     2.163172     2.381393    -3.239384 Ir     2.318999    -0.139202    -0.579493  B     1.831203    -1.330285     1.076850  O     1.946502    -2.727298     1.065414  C     1.367637    -3.244240     2.273267  C     1.478388    -2.023954     3.230726  O     1.379223    -0.917647     2.323204  B     2.055971     1.585770     0.574596  O     2.983764     2.629915     0.657391  C     2.392139     3.715349     1.391178  C     1.311215     2.984383     2.234132  O     0.954273     1.900924     1.366987  B     0.385117    -0.224263    -0.788612  O    -0.910164    -0.370799    -0.771478  C    -1.983816     0.343262    -0.097642  C    -3.289824    -0.292651    -0.662742  O    -4.331940     0.409664     0.029926  B    -5.655175     0.225597    -0.155540  O    -6.571818     1.103211     0.374837  C    -7.871206     0.514785     0.180054  C    -7.629140    -0.429414    -1.039681  O    -6.245666    -0.801669    -0.864125  C     2.061174    -3.145718    -2.664344  C     4.745004     2.074613    -2.094395  H     3.801996    -3.710410    -0.210896  H     2.602703    -3.928416    -3.211508  H     2.721322    -0.259188    -4.287500  H     4.337776     0.448910    -4.459742  H     5.231722    -1.094464    -2.707720  H     4.420962    -2.078324    -3.936599  H     4.558964     2.788031    -1.282507  H     2.673743     2.806999    -4.113248  H     3.829405    -0.080463     0.197922  C     2.839511    -1.917191     3.909711  C     0.373949    -1.912721     4.263433  C     2.143405    -4.473705     2.703651  C    -0.072507    -3.624167     1.949303  H     1.929246     3.185627    -2.531136  179   H     1.221107     1.914421    -3.548302  H     5.078702     2.598740    -2.999285  H     5.523437     1.383175    -1.752974  H     1.409233    -3.607067    -1.913208  H     1.429885    -2.577667    -3.356982  H     4.786460    -3.867467    -1.709115  H     5.148068    -2.590988    -0.496791  C     0.069786     3.795300     2.549793  C     1.862667     2.362014     3.512522  C     1.802958     4.677752     0.366183  C     3.466904     4.413308     2.200148  C    -1.853137     1.819569    -0.437251  C    -1.835906     0.131722     1.400234  C    -3.434207    -0.053692    -2.161591  C    -3.366677    -1.784443    -0.359879  C    -7.723272     0.287801    -2.380473  C    -8.481077    -1.680406    -1.058160  C    -8.878578     1.619731    -0.062224  C    -8.220553    -0.237344     1.456968  H     3.028310     5.182252     2.850688  H     4.024429     3.704155     2.818926  H     4.178518     4.904560     1.525631  H     1.413188     5.592848     0.830239  H     2.594843     4.961805    -0.338904  H     0.993469     4.201718    -0.202727  H     2.061235     3.115036     4.286180  H     1.119018     1.648344     3.890065  H     2.782581     1.797556     3.315123  H     0.315862     4.666799     3.171378  H    -0.437559     4.145124     1.644888  H    -0.638289     3.169140     3.107632  H     1.780677    -4.852919     3.668740  H     2.013063    -5.268323     1.958455  H     3.214555    -4.264316     2.788526  H    -0.582699    -4.081952     2.806385  H    -0.645608    -2.747091     1.621907  H    -0.066776    -4.345934     1.123450  H     0.369138    -2.783867     4.932857  H     0.535758    -1.016209     4.874038  H    -0.610742    -1.823622     3.793159  H     2.979043    -2.683209     4.683212  H     3.653809    -1.994832     3.178269  H     2.912365    -0.930606     4.382945  H    -2.667688     0.615758     1.923174  H    -1.831275    -0.932811     1.656624  H    -0.888674     0.563383     1.744491  180   H    -2.730454     2.364658    -0.072834  H    -0.955774     2.215824     0.051812  H    -1.756630     1.976899    -1.517681  H    -2.559539    -0.436738    -2.697917  H    -4.325154    -0.570910    -2.534776  H    -3.542682     1.013995    -2.382066  H    -2.468711    -2.293738    -0.725991  H    -3.457221    -1.967104     0.716355  H    -4.242789    -2.219439    -0.850228  H    -8.758442     0.548049    -2.631923  H    -7.121222     1.205091    -2.390551  H    -7.337645    -0.378638    -3.160870  H    -9.547167    -1.421088    -1.092487  H    -8.247561    -2.272171    -1.950562  H    -8.299547    -2.307484    -0.180619  H    -9.864833     1.202026    -0.303756  H    -8.980120     2.225551     0.845200  H    -8.567174     2.283162    -0.874222  H    -9.237878    -0.645205     1.424152  H    -7.519429    -1.059062     1.645070  H    -8.156900     0.459918     2.299517  181   Calculated coordinates for 8a. Ir     0.565159    -0.145103    -0.454983  O    -1.571512     2.031756    -0.090300  O    -2.183568     0.624488    -1.769791  O    -2.039556    -1.181019     1.015243  O    -1.407608    -2.560905    -0.694554  C    -4.396513     1.401529    -2.316737  C     1.525265     3.763342     2.636735  C    -2.355037     2.634400    -3.023944  C     0.370610    -0.644004     3.503849  C    -1.062700     1.367036     3.192634  C     2.870835    -3.342846    -1.126668  C    -3.876080     1.923596     0.495772  C     3.065515    -2.726619     1.295756  C    -2.902921     3.979682    -0.505646  C     5.265008    -0.668282    -2.185771  C     3.590727     1.137857    -2.648741  C    -2.303067    -3.223910     2.203619  C     1.095985     3.030177     1.371435  C     3.453544    -2.349932    -0.127887  C    -4.285341    -1.919322     1.467144  C    -3.697279    -2.388086    -1.342190  C     0.368175     0.839501     3.156649  C    -2.991625     1.803797    -1.916236  C    -2.802672    -4.483382    -0.353434  C     2.951032     0.804122     1.876212  C     3.806418     0.458803     0.656972  C     3.784895    -0.301155    -2.186155  C    -2.871513     2.463652    -0.512841  C    -2.878837    -2.344989     1.099258  C    -2.729025    -2.968495    -0.320730  P     2.906719    -0.622436    -0.566925  P     1.147794     1.161647     1.488230  C     1.890831     3.527815     0.170674  B    -1.074797    -1.427462     0.034008  B    -1.242909     0.869097    -0.781073  H     4.073503     1.377188     0.114840  H     3.395177     1.643005     2.432569  H     0.986236     1.377949     3.895911  H     0.033714     3.232584     1.176379  H    -0.265979    -1.197468     2.801791  H     2.572385     3.551441     2.899588  H     4.553932    -2.356236    -0.196499  H     1.975612    -2.677476     1.435828  182   H     3.167632    -4.367799    -0.863373  H     5.442249    -1.736657    -2.010895  H     3.247545    -0.953205    -2.894563  H     4.115595     1.849315    -1.993187  H    -2.276254    -2.646045     3.137269  H    -4.276475    -1.424158     2.447621  H    -2.011088    -4.946119     0.246189  H    -4.733178    -2.695102    -1.142136  H    -3.413570    -2.754039    -2.336742  H    -3.635006    -1.293438    -1.371775  H    -4.952721    -2.790885     1.530552  H    -2.908861    -4.124111     2.372514  H    -1.275537    -3.535856     1.967880  H    -3.776651    -4.835953     0.015888  H     2.935338    -0.048940     2.568541  H     4.752492    -0.012828     0.965159  H     1.372341    -1.095073     3.491310  H     3.383766    -3.756536     1.509670  H     3.536400    -2.076092     2.045966  H     1.772310    -3.294270    -1.124074  H     5.712995    -0.420294    -3.158248  H     5.820903    -0.102867    -1.423166  H    -4.904239     2.226217     0.256195  H    -3.822823     0.828507     0.553265  H    -3.624923     2.317215     1.489368  H    -2.086658     4.407808    -1.098610  H    -2.792300     4.340943     0.526243  H    -2.284427     2.015718    -3.926976  H    -1.336990     2.944888    -2.751236  H     0.334082    -0.931029    -1.859324  H    -2.686729    -4.833302    -1.386840  H    -4.374200     0.914351    -3.300172  H    -5.050192     2.283131    -2.387551  H    -3.858576     4.359177    -0.895315  H     1.451893     4.849109     2.479879  H     4.007150     1.264005    -3.657629  H     2.530530     1.415490    -2.675551  H    -0.040172    -0.788834     4.513753  H    -1.127780     2.445524     2.996365  H    -1.505561     1.179710     4.181695  H    -1.672337     0.847891     2.440673  H     2.971916     3.364751     0.306355  H     1.745159     4.610033     0.044227  H     1.579524     3.030586    -0.756771  H     0.318708    -1.564036     0.508252  H     0.835413     1.126550    -1.457438  183   H    -4.840177     0.697290    -1.603114  H    -2.945286     3.529528    -3.263407  H     0.903794     3.516887     3.506493  H     3.209507    -3.154017    -2.154231  H    -4.704948    -1.217855     0.736886   184   Calculated coordinates for 8b. Ir     0.212321    -0.287193    -0.404395  O    -2.741007    -0.622737     0.459185  O     1.393952     2.559571     0.288776  O    -2.574594     0.538849    -1.492145  O    -0.898512     2.608466     0.283811  C    -4.500781    -0.701465    -2.137555  C    -4.014208     1.243076     1.199409  C    -5.115737    -0.928987     0.680025  C    -4.657750     1.718573    -1.569002  C    -0.727824    -3.870561     2.941807  C     5.155951     0.070074     0.821110  C     3.698610     0.938498    -2.354527  C     1.967245     4.784318     0.981408  C     0.391711    -4.118467    -1.545512  C     1.072811     4.317388    -1.295448  C    -0.526371    -1.382921     3.198233  C     2.949304    -1.349542    -3.018322  C    -0.512410     3.901764     2.246237  C     3.126546     0.249394     2.282386  C    -1.381354     4.953669     0.161150  C    -1.943132    -3.658523    -0.785883  C    -4.009946     0.027724     0.279782  C     1.823587    -2.911757     1.147587  C    -3.977555     0.405088    -1.232008  C    -0.867269    -2.521317     2.244929  C     3.663743     0.372849     0.860904  C     3.600670    -0.520833    -1.917951  C     2.911460    -2.390254     0.208664  C    -0.453458     3.895708     0.722337  C     1.003263     3.935169     0.178080  C    -0.498693    -3.841077    -0.340264  P     2.623645    -0.624424    -0.334647  P     0.101021    -2.381598     0.653514  B     0.226883     1.793213     0.183053  B    -1.866132    -0.127093    -0.510525  H    -5.053542    -1.877036     0.134010  H    -4.167823     2.558446    -1.062570  H    -2.016444    -2.828995    -1.502861  H    -2.623319    -3.444089     0.048634  H    -2.297258    -4.569377    -1.289004  H     0.417396    -3.250037    -2.218672  H    -0.006206    -4.971748    -2.112288  H    -0.436256    -4.705409     0.341274  185   H     3.484689     1.408030     0.538218  H     3.646262     0.957285     2.943285  H     2.051439     0.467565     2.334975  H     3.297715    -0.757781     2.692898  H     5.685928     0.690947     1.557543  H     5.366738    -0.978220     1.080140  H     4.609262    -0.920388    -1.715948  H     2.863353    -2.413489    -2.757979  H     4.206761     1.013153    -3.325993  H    -1.908478    -2.371660     1.920752  H     0.528431    -1.408995     3.513624  H    -1.137916    -1.463755     4.107571  H    -0.259332     4.885450     2.664192  H    -1.532067     3.644381     2.561192  H    -1.496133     4.854294    -0.923528  H    -1.009837     5.963105     0.388686  H    -2.376260     4.849424     0.615426  H     0.367122     3.726579    -1.894122  H     2.086132     4.109513    -1.663627  H     2.962851     4.748891     0.519543  H     1.869207    -4.008519     1.232746  H     1.981873    -2.511775     2.160150  H     2.930064    -2.988569    -0.713124  H     3.904677    -2.499105     0.669758  H     0.065251    -1.117551    -1.799217  H     0.204669     0.696461     1.065093  H    -1.335386    -3.881513     3.857374  H     0.311164    -4.067204     3.243524  H    -1.065931    -4.710714     2.322515  H    -4.240727    -0.458899    -3.175276  H    -5.592388    -0.807743    -2.069800  H    -3.842143     0.900076     2.228664  H     2.061127     4.424762     2.012372  H     1.641962     5.834114     1.001799  H     0.860796     5.383455    -1.452903  H     0.171691     3.153877     2.670780  H     2.693476     1.372605    -2.467088  H     4.251180     1.561677    -1.639410  H     3.544356    -1.284795    -3.940170  H     1.938649    -0.976461    -3.234358  H     5.607235     0.270164    -0.159205  H     1.423427    -4.366820    -1.261677  H    -0.723069    -0.405333     2.742035  H     0.233230     1.059468    -1.388974  H    -5.719898     1.700192    -1.285074  H    -4.599792     1.897013    -2.650001  186   H    -4.971487     1.780964     1.169958  H    -6.105740    -0.486836     0.497011  H    -5.039131    -1.150065     1.753018  H    -4.041421    -1.666917    -1.890341  H    -3.201768     1.932763     0.934729  187  Calculated coordinates for 9. O    -2.655405     0.232489     0.289665 Ir     0.279392    -0.468332    -0.625993  P     0.449381     1.811428     0.069668  P     2.403551    -0.719103     0.305378  C     2.055539     2.007383     1.015317  C     3.116952     0.975507     0.630234  O    -2.544107    -1.963870    -0.362686  C    -3.924849    -1.585076    -0.404234  C    -0.794953     2.595073     1.233207  C    -3.946911    -0.341475     0.529264  B    -1.809364    -0.811533    -0.109818  C     3.724136    -1.534678    -0.723375  C     1.789384     2.833079    -2.189160  C    -4.268096    -1.240773    -1.848422  C     0.594630     3.090466    -1.281451  C     2.527705    -1.614587     1.942855  C     3.869595    -0.895093    -2.099104  C    -0.960135     1.766389     2.501336  C     1.711087    -0.898889     3.011635  C    -4.770628    -2.751711     0.064432  C     3.946336    -1.859432     2.444121  C    -0.699617     3.131519    -2.086299  C     3.423944    -3.022647    -0.875832  C    -5.010463     0.688939     0.207684  C    -4.012700    -0.711141     2.006627  C    -0.512935     4.052725     1.579173  H    -1.095410    -0.287557    -1.552137  H     0.313670    -1.981150    -1.239560  H     3.909541     0.923385     1.392049  H     1.823236     3.587478    -2.988092  H     0.747586     4.061639    -0.783012  H     2.441503    -3.165300    -1.347863  H     4.085558     0.180769    -2.055586  H     3.913418    -2.365857     3.419139  H     1.720567     1.843448    -2.660038  H    -0.056187     1.783423     3.129109  H    -4.935381     1.527477     0.913152  H     2.041632    -2.582668     1.736406  H     2.447379     3.028883     0.896561  H    -1.744708     2.519803     0.681231  H    -4.437513    -3.128003     1.037821  H    -0.558930     4.717239     0.707783  H     0.685845    -0.695932     2.678295  H     2.745032     2.889433    -1.649507  H    -1.574348     3.372792    -1.466944  188   H    -3.814015     0.188216     2.604589  H     1.794489     1.890712     2.077445  H    -4.893219     1.089239    -0.805397  H     4.696799    -1.374421    -2.641138  H     4.490689    -0.915712     2.595182  H    -3.250683    -1.460967     2.259281  H    -4.015514    -2.098619    -2.483638  H     4.542400    -2.487368     1.771737  H    -6.017241     0.257543     0.302206  H    -1.778989     2.179501     3.108055  H     2.952089    -1.029078    -2.685970  H    -4.693861    -3.575011    -0.656953  H    -5.336711    -1.018227    -1.973319  H    -1.257882     4.416672     2.301304  H     2.179498     0.056499     3.294627  H     3.608099     1.272546    -0.307456  H     1.658055    -1.512141     3.921595  H     3.416319    -3.560258     0.080814  H     4.179919    -3.497277    -1.516574  H     4.670571    -1.399071    -0.172181  H    -5.828947    -2.462860     0.139064  H    -1.212235     0.724901     2.271035  H    -0.887139     2.158235    -2.561426  H    -0.633691     3.889444    -2.879589  H     0.474443     4.176955     2.048356  H    -3.686699    -0.378461    -2.200493  H    -4.998238    -1.103779     2.290642  H     1.075961    -0.103525    -1.989551  H    -0.719114    -1.081041     0.719926   189   Calculated coordinates for 10. Ir     0.205474    -0.218043     1.385189  P     1.318376    -1.565169     2.831900  P    -1.704417    -1.558113     1.835549  C     0.221615    -2.976498     3.382460  H     0.435504    -3.820041     2.709546  H     0.507572    -3.303079     4.394241  C    -1.263844    -2.617483     3.320762  H    -1.541035    -2.025417     4.204757  H    -1.882869    -3.526714     3.351042  C    -3.271921    -0.725641     2.416390  H    -3.935565    -1.518267     2.802825  C    -3.946159    -0.014838     1.246385  H    -4.211595    -0.692274     0.423718  H    -3.274876     0.753980     0.836617  H    -4.867292     0.482180     1.583407  C    -3.003944     0.275766     3.532937  H    -2.557998    -0.184767     4.424635  H    -3.946081     0.748832     3.845803  H    -2.321423     1.064191     3.187419  C    -2.354327    -2.804857     0.597039  H    -2.590117    -2.184774    -0.282425  C    -3.601008    -3.568248     1.024530  H    -3.433242    -4.149073     1.944084  H    -3.885193    -4.287085     0.242315  H    -4.465341    -2.914338     1.195977  C    -1.243083    -3.761327     0.187275  H    -0.961611    -4.430736     1.015287  H    -0.351274    -3.215792    -0.146104  H    -1.577455    -4.400427    -0.642291  C     1.915771    -0.853580     4.449781  H     2.400483    -1.687685     4.984044  C     2.932707     0.254969     4.211963  H     3.820692    -0.095970     3.669475  H     3.273406     0.671785     5.170440  H     2.481197     1.066199     3.624467  C     0.767200    -0.347126     5.312370  H     0.041030    -1.135533     5.554470  H     0.230506     0.468755     4.809059  H     1.157088     0.041751     6.263917  C     2.854686    -2.415935     2.180793  H     3.508144    -1.570789     1.905409  C     3.575726    -3.293479     3.198971  H     2.917091    -4.084591     3.587302  190   H     3.964770    -2.726966     4.054013  H     4.430981    -3.794116     2.723065  C     2.563479    -3.205837     0.910191  H     1.986162    -4.117889     1.124814  H     3.506602    -3.527686     0.446160  H     2.003226    -2.612696     0.175269  H     1.538874     0.724070     1.242605  H     0.636170    -0.977456    -0.333584 Ir    -0.205474     0.218043    -1.385189  P    -1.318376     1.565169    -2.831900  P     1.704417     1.558113    -1.835549  C    -0.221615     2.976498    -3.382460  H    -0.435504     3.820041    -2.709546  H    -0.507572     3.303079    -4.394241  C     1.263844     2.617483    -3.320762  H     1.541035     2.025417    -4.204757  H     1.882869     3.526714    -3.351042  C     3.271921     0.725641    -2.416390  H     3.935565     1.518267    -2.802825  C     3.946159     0.014838    -1.246385  H     4.211595     0.692274    -0.423718  H     3.274876    -0.753980    -0.836617  H     4.867292    -0.482180    -1.583407  C     3.003944    -0.275766    -3.532937  H     2.557998     0.184767    -4.424635  H     3.946081    -0.748832    -3.845803  H     2.321423    -1.064191    -3.187419  C     2.354327     2.804857    -0.597039  H     2.590117     2.184774     0.282425  C     3.601008     3.568248    -1.024530  H     3.433242     4.149073    -1.944084  H     3.885193     4.287085    -0.242315  H     4.465341     2.914338    -1.195977  C     1.243083     3.761327    -0.187275  H     0.961611     4.430736    -1.015287  H     0.351274     3.215792     0.146104  H     1.577455     4.400427     0.642291  C    -1.915771     0.853580    -4.449781  H    -2.400483     1.687685    -4.984044  C    -2.932707    -0.254969    -4.211963  H    -3.820692     0.095970    -3.669475  H    -3.273406    -0.671785    -5.170440  H    -2.481197    -1.066199    -3.624467  C    -0.767200     0.347126    -5.312370  H    -0.041030     1.135533    -5.554470  H    -0.230506    -0.468755    -4.809059  191   H    -1.157088    -0.041751    -6.263917  C    -2.854686     2.415935    -2.180793  H    -3.508144     1.570789    -1.905409  C    -3.575726     3.293479    -3.198971  H    -2.917091     4.084591    -3.587302  H    -3.964770     2.726966    -4.054013  H    -4.430981     3.794116    -2.723065  C    -2.563479     3.205837    -0.910191  H    -1.986162     4.117889    -1.124814  H    -3.506602     3.527686    -0.446160  H    -2.003226     2.612696    -0.175269  H    -1.538874    -0.724070    -1.242605  H    -0.636170     0.977456     0.333584  H    -0.074481     0.682969     2.685061  H     0.074481    -0.682969    -2.685061   192  Calculated coordinates for [(dippe)IrH(µ-H)]2. Ir     0.443634    -0.506442     1.307177  P     1.437788    -1.757278     2.945249  P    -1.532150    -1.677717     1.809910  C     0.278576    -3.122816     3.488554  H     0.501373    -3.989544     2.847550  H     0.501994    -3.430152     4.522187  C    -1.190085    -2.727307     3.336481  H    -1.501262    -2.114970     4.195882  H    -1.836284    -3.617620     3.347405  C    -3.043744    -0.735145     2.394938  H    -3.671784    -1.446680     2.960617  C    -3.846485    -0.160955     1.232270  H    -4.261587    -0.935370     0.574045  H    -3.212453     0.483770     0.607305  H    -4.684579     0.439865     1.615083  C    -2.613173     0.391732     3.327347  H    -2.045102     0.032180     4.195807  H    -3.492919     0.932462     3.705887  H    -1.975271     1.109276     2.789314  C    -2.242146    -2.900462     0.586704  H    -2.533012    -2.257966    -0.260226  C    -3.451416    -3.687361     1.073291  H    -3.189664    -4.357363     1.905804  H    -3.838323    -4.324274     0.264443  H    -4.276637    -3.046540     1.408892  C    -1.143436    -3.836674     0.101796  H    -0.759573    -4.461283     0.924302  H    -0.302528    -3.274954    -0.324516  H    -1.530492    -4.519132    -0.668725  C     1.960396    -0.960971     4.550426  H     2.280492    -1.771441     5.227462  C     3.120179     0.001342     4.323045  H     4.037470    -0.509893     4.004119  H     3.350886     0.543532     5.251128  H     2.860776     0.739843     3.550783  C     0.783767    -0.227988     5.182873  H    -0.058601    -0.896669     5.408557  H     0.417499     0.564090     4.512409  H     1.091290     0.243172     6.127449  C     2.980114    -2.660987     2.405328  H     3.689771    -1.840678     2.206770  C     3.564591    -3.595719     3.457639  H     2.870636    -4.415010     3.695902  H     3.813476    -3.081790     4.395142  H     4.488759    -4.057891     3.082071  193   C     2.748221    -3.392083     1.088213  H     2.066647    -4.246714     1.212684  H     3.698397    -3.790631     0.704663  H     2.315442    -2.721890     0.333137  H     1.877346     0.297043     1.067853  H     0.387359    -0.824954    -0.399368 Ir    -0.443634     0.506442    -1.307177  P    -1.437788     1.757278    -2.945249  P     1.532150     1.677717    -1.809910  C    -0.278576     3.122816    -3.488554  H    -0.501373     3.989544    -2.847550  H    -0.501994     3.430152    -4.522187  C     1.190085     2.727307    -3.336481  H     1.501262     2.114970    -4.195882  H     1.836284     3.617620    -3.347405  C     3.043744     0.735145    -2.394938  H     3.671784     1.446680    -2.960617  C     3.846485     0.160955    -1.232270  H     4.261587     0.935370    -0.574045  H     3.212453    -0.483770    -0.607305  H     4.684579    -0.439865    -1.615083  C     2.613173    -0.391732    -3.327347  H     2.045102    -0.032180    -4.195807  H     3.492919    -0.932462    -3.705887  H     1.975271    -1.109276    -2.789314  C     2.242146     2.900462    -0.586704  H     2.533012     2.257966     0.260226  C     3.451416     3.687361    -1.073291  H     3.189664     4.357363    -1.905804  H     3.838323     4.324274    -0.264443  H     4.276637     3.046540    -1.408892  C     1.143436     3.836674    -0.101796  H     0.759573     4.461283    -0.924302  H     0.302528     3.274954     0.324516  H     1.530492     4.519132     0.668725  C    -1.960396     0.960971    -4.550426  H    -2.280492     1.771441    -5.227462  C    -3.120179    -0.001342    -4.323045  H    -4.037470     0.509893    -4.004119  H    -3.350886    -0.543532    -5.251128  H    -2.860776    -0.739843    -3.550783  C    -0.783767     0.227988    -5.182873  H     0.058601     0.896669    -5.408557  H    -0.417499    -0.564090    -4.512409  H    -1.091290    -0.243172    -6.127449  C    -2.980114     2.660987    -2.405328  194   H    -3.689771     1.840678    -2.206770  C    -3.564591     3.595719    -3.457639  H    -2.870636     4.415010    -3.695902  H    -3.813476     3.081790    -4.395142  H    -4.488759     4.057891    -3.082071  C    -2.748221     3.392083    -1.088213  H    -2.066647     4.246714    -1.212684  H    -3.698397     3.790631    -0.704663  H    -2.315442     2.721890    -0.333137  H    -1.877346    -0.297043    -1.067853  H    -0.387359     0.824954     0.399368