‘E‘Hfi GERMl-HATW 0F BASWlOSPORES o? cmvgm WAND RELATED GENERA Thesis for 9h. Dear» of Ph D. MICHKEM‘S STATE UNIVERSWY Glenn Stuart Bulmar W60 0-169 MHWH mm M M m3 1293 107 o'fl—fl This is to certify that the thesis entitled The Germination of Baaidioepores of Salvatia. gigantea and fieIated Genera presented by Glenn StuartiBulmer' has been accepted towards fulfillment of the requirements for m—degree mm (Dept. of Botany & Plant Pathology) 5%(1 /(’/r’-’c~_ rolessor E. S. Bgne a Date ember 21 1 60 LIBRA R Y Michigan State University MSU LIBRARIES RETURNING MATERIALS: Place in book drop to remove this checkout from your record. FINES will be charged if book is returned after the date stamped below. ul lil. 7%,} Ea.l’i"..i THE GERMINATION OF BASIDIOSPORES OF CALVATIA GIGANTEA AND RELATED GENERA BY Glenn Stuart Bulmer A THESIS Submitted to the School for Advanced Graduate Studies of Midhigan State University of Agriculture and Applied Science in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Department of Botany and Plant Pathology 1960 g /s’// 2— 0/,/ 9/ (a I ii ACKNOWLEDGEMENT S The author wishes to express his sincere thanks to Dr. E. S. Beneke for an introduction to the fungi as an undergraduate student and the guidance, counsel and encouragement so freely given throughout the author's graduate studies. Without his support these investigations would not have been possible. Sincere appreciation is also due to Drs. W. B. Drew, J. L. Lockwood, G. L. Kilgour, R. L. Kiesling, G. P. Steinbauer, and J. A. Stevens for their many helpful suggestions throughout this investigation. The writer is indebted to P. G. Coleman for photo- graphic preparations; Sigrid Heine for technical assistance and the Parke Davis Company for their supplies of chloromycetin. This investigation was supported by the Rackham Research Foundation and the National Institutes of Health for which the author is indebted. Sincere thanks are due the Mycological Society of America for presenting the author with the 1958—59 Fellowship. To my wife and our three little Lycoperdons: Scott, Gary and Cindy. THE GERMINATION OF BASIDIOSPORES OF CALVATIA GIGANTEA AND RELATED GENERA BY Glenn Stuart Bulmer AN ABSTRACT Submitted to the School for Advanced Graduate Studies of Michigan State University of Agricultura and Applied Science in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Department of Botany and Plant Pathology Year 1960 Approved 933*42zéfigfl g::L¢
75% of that of controls.
A ? designation indicated an incomplete test owing to the death
of two or more of the test mice.
Mating Experiments
Two cm3 blocks of Medium A.were placed 1 cm apart
on a flamed microscope slide in a sterile Petri dish containing
5 m1 of sterile water. Small mycelial transfers from
cultures of g, qiqantea were inoculated on the edges of these
blocks. A flamed cover slip was then placed on top of these
blocks, bridging them. When completed, this apparatus was
incubated at 26°C. In 2-3 weeks the mycelium from each
block had grown onto the underside of the cover slip. As
the hyphae approached and overlapped each other, the cover
slip was removed and permanently mounted on another microscope
slide.
Antifungal Activity
Two techniques were employed in attempts to assay
antifungal activity of g, qigantea mycelium.
One method tested activity of g. qigantea mycelium
16
against cultures of Glomerella cingulata (Stoneman) Spaulding
and Schrenk. A 50 m1 aqueous suspension containing 1.4 x 107
.Q. cingulata conidia was added to 200 ml of cooled (41°C) 2%
agar enriched with 0.5% Bacto-Peptone. These plates were
then divided into three groups: (a) cultures incubated at
26°C for 12 hours before they were inoculated with g, gigantea
mycelium; (b) cultures incubated for 4 days at 26°C and then
inoculated with g, gigantea mycelium: (c) cultures incubated
for 4 days at 26°C, then killed by placing in a desiccator
containing propylene oxide. Plates were removed after 6—8
hours, covered with one layer of sterile cheesecloth and
allowed to air out overnight before they were inoculated with
“Q. gigantea mycelium.
The centers of all plates were inoculated with 1/4"
cylinders cut from agar cultures of g. qiqantea.
Mycelium of Q. gigantea was also tested for antifungal
activity against Candida albicans (Robin) Berkhout,
Colletotrichum phomoides Saccardo (Chester) and Trichophyton
mentagrophytes (Robin) Blanchard in the following manner:
Petri dishes containing Medium A were inoculated
with three 1/4" cylinders cut from the edges of agar cultures
of g. gigantea and incubated for three days at 26°C. At
this time streaks of the test organisms were made on the
medium radial to the g. gigantea cylinders.
Two sources of Q. gigantes mycelium were tested:
(a) mycelium originally derived from immature sporophores,
17
(b) mycelium derived from spores germinated on barley extract
medium.
In some instances, additional materials and methods
are cited in results and observations. This was done to
aid the reader in interpreting the experimental work.
18
RESULTS AND OBSERVATIONS
Pgeliminary Investigations to Germinate BasidiOspores
There appear to be no published reports of attempts
to germinate the basidiospores of g, gigantea. With this
in mind, it was decided to start these investigations by
using various media at different temperatures, and by pre-
treatment of spores with various methods.
In the first series of experiments various media at
incubation temperatures of 28°C and 35°C were used (Table l).
Chloromycetin was not used in media in these experiments.
Experiments were terminated after 30 days incubation.
This period was selected because Fries (1941) noted that
30 days was the longest period required for colonies to
appear from Lycoperdon s2, spores. Media were inoculated by
lightly shaking a small portion of sporophore material above
the plates thus dispersing spores onto the surface of the
media.
Contamination by fungi and particularly bacteria was
a great problem in these experiments, but a sufficient number
of clean plates were obtained to evaluate the media. None
of the media supported germination of basidiospores from
the sporophores used (Table 1).
In further germination experiments spores of g,
gigantea were subjected to various pretreatments. After
each treatment the Spores were kept for 24 hours in sterile
TABLE 1
19
Agar media used unsuccessfully in preliminary attempts to
germinate basidiospores of Q. gigantea.
incubated for 30 days at 28°C or 35°C.
Plates were
Media
1. Steamed Puffball Extrace
2. Blended Puffball Extract
3. Soil Extract
4. Sabouraud's inoculated at
4 places with R.M.a yeast
5. Malt Extract inouclated at
4 places with R.M. yeast
6. ,Soil extract inoculated at
4 places with R.M. yeast
7. Steamed Puffball extract
inoculated at 4 places
with R.M. yeast
8. Potato Dextrose
9. Litman's Oxgall
10. Difco Blood Agar base
Sporophore Number
961,
961,
998,
983
985.
995,
995
995,
995,
995
948,
948,
989,
989,
985,
985,
984
983,
983,
954’
984
989,
984
971, 970
971, 970
961, 986,
984
aR.M yeast (Rhototorula muscilaginosa var. sanguinea.)
20
distilled water and examined microscopically for germination.
Treated
spores were streaked on Medium A without chloro-
mycetin contained in Petri dishes. These diShes were
incubated for 20 days and examined periodically for germina-
tion.
many as
treated
1.
Owing to contaminants it was necessary to use as
20 plates of Medium A agar for each sample of pre-
spores. Pretreatments of spores are recorded below.
Spores from sporophore #995 were washed with 95%
ethanol for periods of one, five and ten minutes.
Spores from sporophore #989 were heated for 5
minutes at the following temperatures: 35°C, 40°C,
45°C, 50°C, 55°C, and 60°C.
Spores from sporophores #995 and #986 were dipped
into the following concentrations of sulphuric acid
for 5 minutes: 1, 10, 25, 50%.
The walls of spores from sporophore #1373 were
etched in a Nasal disintegrator.
Spores from sporophore #984 were incubated for 20
hours in sterile solutions of Bile salts ranging
from 0.25 to 15%.
Spores from sporophore #939 were alternately frozen
and thawed six times over a three day period.
Spores from sporophores #972, #986 were heated at
50°C, 60°C, 70°C, and 80°C for intervals of 5, 10,
15, 20, and 25 minutes.
21
8. Spores from sporophore #1373 were placed in the
following glucose concentrations for 24 hours:
0.5, 1.0, 5, 10%.
9. Forty gm of a Q, gigantea sporophore (immature)
was blended for 5 minutes with 500 ml of distilled
water. This preparation was filtered through a
Seitz apparatus. Spores from sporophore #1373
were incubated for 3 days in this preparation.
10. Spores from sporophore #1380 were incubated at 28°C
for 24 hours in a 1% solution of Pancreatin extract
that had been filtered through a Seitz apparatus.
None of these treatments was successful in germinating
the spores of g. gigantea.
Germination in Liquid Cultures
Barley extract broth and spores of Q, gigantea #995
were used. All flasks were incubated on a rotary shaking
machine. During the first two weeks of incubation, several
of the flasks contained fungal growth which was later
identified as a contaminant(s). The remaining flasks were
left on the shaker for several more weeks. Finally after
9 weeks incubation, mycelium growing on the original piece
of spore inoculum was observed in 3 of the 6 remaining flasks.
Samples of this mycelium were transferred to Medium A agar.
This culture could not be identified as any previously
described fungus. Since there is apparently no fungus
22
generally classified as a laboratory contaminant that requires
nine weeks from spore germination to colony development, this
fungus was compared with a culture obtained from the immature
sporophore. Both cultures were buff-brown in color. The
centers were slightly raised and growth was relatively flat.
They turned the medium slightly brown and three weeks were
required for these cultures to reach one-inch in diameter.
The hyphae were 2-3.5 microns in diameter and lacked
reproductive structures except for occasional Chlamydospores.
In subsequent experiments, using spores of Q. gigantea
#995 in barley extract broth, germination was observed after
7-8 weeks incubation (e.g., Plate I). The number of
germinating spores calculated after eight weeks incubation
indicated that less than one spore out of 20 million had
germinated. An occasional spore appeared to have an appressorium.
However, these structures were never observed giving rise
to hyphae. Advanced stages of spore germination were never
seen, as observed microscopically, once the germ tube
protruded to a length of approximately five microns, it
appeared to be broken off by the action of the shaking machine.
Capillitium was never seen giving rise to hypha, in
fact, most of these threads did not contain complete cells.
From the above evidence it was decided that spores
from Q. gigantea had been germinated. Later, in support of
this contention, mycelium derived in a similar manner
un’,.fl‘.l I I’ll EL.
23
Plate I. A germinated basidiospore of g.
gigantea #995 incubated on '
shaker for 8 weeks at 26°C in
barley extract broth.
24
demonstrated antifungal and tumor-retarding properties.
It was of interest to determine if the spores of
Q, gigantea could be germinated in broth other than barley
extract. Various broth media were, therefore, investigated
(Table 2). Spores from sporophore #995 were incubated for
90 days at 26°C. If no growth occurred after this period of
time, it was considered that the spores would not germinate
under the experimental conditions.
Spores from sporophore #995 were germinated in six of
the ten media, the most successful of which were the barley
and puffball extracts containing chloromycetin. Of the 18
flasks containing 9, gigantea mycelium 16 had chloromycetin
incorporated into the broth. The media lacking the anti—
biotic were mostly contaminated with bacteria.
In later experiments, employing barley extract broth,
spores from sporophores of g, gigantea #1373, 1096E, 1369,
and 1389: L, pyriforme #1374: L. gemmatum #1383, 1403: and
.E- echinatum Pers. #1384 were gernimated. No germination
was observed using spores of g, gigantea #1370, 1376, 1380:
_L_. gemmatum #1385: or _I_.. pyriforme #1386.
These results indicated that spores from some 9.
gigantea and Lycoperdon EB: sporophores could be germinated
in barley extract broth.
Spore Germination Results from
Q, gigantea #995 grown in
TABLE 2
Various Media
25
Chloromycetin a b
Broth Incorporated FFF M.P.
(l) Sabouraud's yes 2/5 1
plus one day
autoclaved no 1/5 0
R.M. Yeast
(2) Sabouraud‘s yes 2/5 0
plus 3 day
autoclaved no 2/5 1
R.M. yeast
(3) Sabouraud's plus yes 4/5 0
living R.M. yeast no 4/5 0
(4) Autoclaved yes 4/5 0
Soil Extract no 4/5 0
(5) Seitz Filtered yes 4/5 0
Soil Extract no 4/5 0
(6) Puffball Extract, yes 3/5 3
Autoclaved no 4/5 0
(7) Puffball Extract, yes 3/5 3
Seitz Filtered no 4/5 0
(8) Medium A yes 8/10 0
no 9/10 0
(9) Medium A yes 3/5 2
plus Pancreatin no 1/5 1
(10) Barley yes 9/10 8
Extract no 7/10 0
aRatio of flasks free from fungal contamination to
original number of f1a9ks.
b
g, gigantea.
Number of flasks containing mycelial pellets of
26
C. gigantea Spore Germination in Agar Medium
Despite the fact that spores of g, gigantea had been
germinated in broth, it was considered more desirable to
germinate them in solid medium so that conditions necessary
for germination could be more accurately defined and the
chances of securing monosporous cultures might be increased.
Fries' (1941) technique which was successful in
germinating spores of Lycoperdon s2, was modified slightly
for these experiments. Spores of an overwintered puffball
(#1390A) were used.
In this experiment 40 Petri dishes containing malt
extract agar (without Chloromycetin) were seeded With spores,
and 20 of them were inoculated at 4 equidistant spots with
R.M. yeast. No R.M. yeast was inoculated into the remaining
plates. Each dish contained 36 x 106 spores and was
incubated at 28°C. Periodically, these plates were examined
for evidences of spore germination. After 4 weeks, an
average of 36 small white colonies (l colony per million
spores inoculated) were seen growing in each Petri dish
inoculated with the yeast. One hundred and eight colonies
(3 colonies per million spores) were counted after 7 weeks'
incubation. This number never increased, in spite of an
additional 4 weeks incubation. Mycelium.was transferred
from several of these cultures and placed on slants of Medium
A agar. Two weeks later these cultures exhibited characteristics
similar to the cultures which were derived from Q. gigantea
27
spore germination in barley extract broth (pp. 21. 22). It
was decided that these were colonies of Q, gigantea. No
colonies appeared in any of the plates that had not been
inoculated with the yeast. Plate II shows a typical Petri
dish containing R.M. yeast and §,'gigantea colonies.
In subsequent experiments, using spores from a minimum
of eight sporophores, it was observed that Q. gigantea
colonies appeared only in malt extract agar that had been
inoculated with the R.M. yeast. -Apparently this living yeast
is necessary for germination to occur in solid media.
Owing to the fact that these colonies appeared to
originate $2 the medium it was not possible to determine if
they were derived fromlg. gigantea spores. This difficulty
was overcome by seeding 44 x 106 spores from #1390AF evenly
on the surface of malt extract agar in Petri dishes. One-
half of this seeded surface was covered with an additional
layer of malt extract agar and inoculated with the R.M.
yeast and incubated at 28°C. After 597 weeks the added
section of medium from some of these dishes was removed and
the germination of g. gigantea spores was observed micro-
scopically (Plates III, IV, V). The remaining dishes contained
9, gigantea colonies after an additional 2 weeks' incubation.
This was considered evidence that spores of Q. gigantea
had been germinated in a solid medium.
It was observed in this experiment that the medium
which had spores uncovered supported an average of 8 colonies
28
Plate II. Colonies resulting from the
germinated spores of g.
gigantea in malt extract agar
incubated at 260C for 9 weeks.
The larger orange colonies are
the R.M. yeast.
Plate III.
Germinated spores of g, o
gigantea incubated at 26 C
for 5 weeks in malt extract
agar inoculated with the R.M.
yeast.
29
it
‘.
u
"x
Plate IV.
Germinated spore of Q. gigantea
incubated at 26°C for 6 weeks
in malt extract agar inoculated
with the R.M. yeast.
30
Plate V.
Colony of g, gigantea derived from
spore germination in malt extract
agar inoculated with the R.M. yeast
and incubated at 26°C for 7 weeks.
Note numerous ungerminated spores and
capillitium.
31
32
and the section that was covered had 65 colonies (Plate VI).
The germination per million spores inoculated was 0.4 and 2.9
respectively (Plate VI). Throughout the ensuing months,
the germination of spores from at least 24 different
sporophores verified the observation that more spores of
IQ. gigantea germinate when covered with a layer of medium.
This rate was similar to that obtained when spores were
seeded into the malt extract medium. Possibly spores from Q.
gigantea require microaerobic conditions for germination.
However, exceptions to this would be the spores that
germinated on the agar surface and those in heavily aerated
broths (i.e., barley extract).
In concurrent experiments when spores from #1390AF
were seeded into malt extract medium and inoculated with
R.M. yeast the germination rate was 2.8 per million. Since
2.9 spores per million germinated when dispensed on the medium
covered with additional agar medium, it was concluded that
seeding spores at 42°C did not effect germination results.
The Effect of Vitamins on Germination
Fries (1941) attempted to replace the living yeast
with various vitamins in his studies on Lycoperdon s2.
spore germination. Although he failed, Cochrane (1958)
mentioned that this co-culture with a yeast is suggestive of
a vitamin effect.
The folldwing vitamins were investigated. In every
Plate VI.
33
Colonies resulting from germinated
spores of g. gigantea #1390AF incubated
at 26°C for 8 weeks. Spores on the
right side of the Petri dish were
covered with malt extract agar while
spores on the left side were not
covered.
34
case Petri dishes containing malt extract agar seeded with
.9. gigantea spores and inoculated with R.M. yeast were a
control. In these experiments spores from either #1400C or
#1390AF were used.
1. Biotin: Concentrations of 5, 10, and 15 pg/l were
attained in the following media: Medium A lacking yeast
extract. Medium A lacking yeast extract and peptone, malt
extract agar, and Magenmaltz agar (Fries. 1943). In
preliminary experiments, without Chloromycetin, colonies which
strongly resembled Q. gigantea appeared in some of the above.
These were subsequently always considered to be 9. gigantea
. colonies for reasons outlined previously. However, close
examination revealed there were some bacteria present. In
subsequent experiments, when Chloromycetin was used to inhibit
bacteria, none appeared.
2. Thiamine: Concentrations of 75, 100 and 125‘pg/l‘were
attained in the following media: malt extract agar, Magenmaltz
agar, Medium A lacking yeast extract, and Medium A lacking
yeast extract and peptone. In one instance 10 concentrations
of thiamine (from 50 up to SOO‘ug/l) were attained in malt
extract agar. Ithhese experiments no colonies of Q. gigantea
appeared except in one of 10 plates containing malt extract.
350lug/l thiamine, and spores of Q. gigantea #1400C. This
plate did not contain contaminating bacteria.'
3. Pyridoxine: Concentrations of 50, 100, and 200~pg/1
were attained in Medium A lacking peptone and yeast extract.
35
No colonies of Q. gigantea were observed.
4. Inositol: Concentrations of 50, 100 and 200.pg/1 were
attained in Medium A lacking yeast extract and peptone. No
colonies of Q, gigantea were observed.
5. Riboflavin: Concentrations of 10, 20, 40 pg/l were
attained in malt extract agar. No colonies of Q. gigantea
were observed.
Attempts to replace the R.M. yeast with various
vitamins were not successful. This should not be taken as
evidence that a vitamin is not important in the spore
germination of Q. gigantea. For example, the combination of
two or more vitamins could be necessary. It is also possible
that the yeast masks or neutralizes germination inhibitor(s).
Spore germination always occurred in malt extract
medium which was inoculated with R.M. yeast.
In the biotin substitution experiments, a contaminating
bacterium appeared to stimulate germination. To investigate
this further, 30 plates of malt extract agar (minus
Chloromycetin) were seeded with spores of Q. gigantea #1400C.
Ten of these plates were inoculated with R.M. yeast in the
usual manner. Another 10 plates were inoculated at 4 places
with the unknown bacterium. The remaining plates were
streaked at 2 places with this bacterium. After 7 weeks
the control plates had an average of 7.5 colonies/million
spores inoculated, the plates containing the 4 colonies of the
bacterium had 4.6 colonies/million spores inoculated and the
36
streaked plates had 7.5 colonies/million spores inoculated.
This demonstrated that this bacterium can quantitatively
replace the function of the R.M. yeast.
Effect of Chloromycetin
Early attempts to germinate the spores of g, gigantea
were continually hampered by bacterial contamination probably
from the gleba. Swartz (1929) noticed this and reported on
the microflora in the basidiocarp of various puffballs.
It was decided that a bacteriostatic compound must be
incorporated into the media. Chloromycetin was selected
since it was readily available and maintained its integrity
throughout autoclaving.
After 6 weeks in an exploratory experiment, with
spores from Q. gigantea #1390A, dishes without Chloromycetin
contained an average of 31 colonies per million spores
inoculated, yet the medium containing 100 ppm of bacterial
inhibitor had only 18 colonies per million of g. gigantea.
Six concentrations of Chloromycetin (1.0, 2.5, 5.0, 10.0, 15.0
and 30.0 ppm per liter) were tested using spores of #1397A.
Plates were incubated 7 weeks at 26°C. The results are
shown in Figure 1.
The medium lacking Chloromycetin contained 16.5
colonies per dish. With 1, 2.5, and 5 ppm of Chloromycetin
an average of 27, 20, and 18 respectively were observed in
each dish. As the concentration increased further the number
37
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«nmmae
mwucmoflc aw mo coflumcflfiumw whomm :0 com sameMEouoHfio pommmm one
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38
of colonies per plate gradually fell off until, at 30 ppm
of chloromycetin. only 12.5 colonies per dish were recorded.
A concentration of 6 ppm of Chloromycetin was selected
for use in future experiments based on two considerations:
(1) at this level the average number of colonies per plate
(or germ/million) was similar to the medium containing no
Chloromycetin: (2) this concentration was sufficient to
inhibit most bacteria. 1
It was interesting to note that the greatest number
of colonies per dish was obtained at a concentration of 1 ppm
chloromycetin. This increase might well be an oligodynamic
effect. This term, as used by Foster (1949) states that
". . . strong poisons actually‘may be stimulatory if furnished
in subinhibitory doses." Plating of portions of the medium
from these plates onto Sabouraud's agar Showed no evidence
of bacteria. Thus the increased number of colonies was not
due to bacterial contamination in these dishes.
Manometric studies were undertaken in an attempt to
ascertain the extent of oxygen uptake depression by a
concentration of 6 ppm of Chloromycetin onspores of g.
'gigantea.
Figure 2 records the effect of various doses of
Chloromycetin on the oxygen uptake by g, gigantea spores
#1390AF. All readings were taken 2 1/2 hours after the
start of the Warburg.
Concentrations of Chloromycetin up to 2.5 ppm did not
39
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Om mm ON ma OH m
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40
appreciably effect the oxygen uptake by spores of g, gigantea
#1390AF. At a level of 3.7 ppm the uptake was slightly
depressed. At 5.0 and 7.5 ppm this depression was more
extensive but had leveled off. Concentrations above 7.5
ppm resulted in a more extensive reducing of the oxygen
uptake. In all instances the negligible number of bacteria
in each Warburg flask and the ccmplete lack of a lag phase
demonstrated that the recorded oxygen uptake was not due to
bacteria.
These studies indicated that a dosage of 6 ppm
Chloromycetin does reduce oxygen uptake but not nearly as
much as a concentration of 15 ppm. This evidence was taken
as support for not using Chloromycetin in excess of 7.5 ppm
for spore germination studies. The increased reduction in
oxygen uptake beyond this dosage might reflect some extensive
metabolic changes.
Effect of C._gigantea Mycelium
It was previously found that all colonies of Q.
gigantea appeared in the first 8 weeks following seeding.
However, if the Q. gigantea mycelium was eventually stimulating
further spore germinations this could be difficult to determine
if the newly developed germinated colonies from germinated
spores occurred adjacent to or under previous Q. gigantea
colonies.
In an attempt to ascertain if g. gigantea mycelium
41
could stimulate germination of Q. gigantea spores (#1390AF),
30 Petri dishes containing malt extract medium were prepared.
Ten of these plates were inoculated with R.M. yeast and the
remainder were inoculated with cultures of Q. gigantea
which had been obtained from a former germination experiment
using spores from sporophore #1400C. After 2 months incuba-
tion at 26°C the plates with yeast contained 13 colonies/million
spores. The plates containing the g, gigantea culture
contained no colonies even after 4 months incubation. Thus
it seems doubtful that mycelium of g, gigantea can stimulate
spore germination in malt extract agar.
Other Factors Possibly Affecting Germination
Throughout the fall and early part of the winter of
1959 the spores from various sporophores of g, gigantea were
tested for germination. The results of these germination
experiments are recorded in Table 3 (28°C incubation). This
data indicated that several factors probably affected spore
germination:
l. The concentration of spores per Petri dish. The
number of spores per million that germinated from Q. gigantea
sporophores #1391A, and #1389 appeared to vary With the
spore concentration.
2. .The sphorophore. Spores from certain sporophores
(#1096E, 1370, 1376 and 1400A) did not germinate in malt
extract agar containing R.M. yeast.
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n.mm o.mga ¢.m mm mhma
o o o.m~ m =
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44
3. Storage conditions. Spores from half a puffball
stored at room temperature (#1390A) gave a germination rate
of 2.7 per million. Yet the other half of this sporophore
(#1390AF) stored for the same length of time at 12°C had
a germination rate of 30.8 spores per million. As the storage
time increased the number of spores from sporophore #1390AF
which germinated decreased.
Thus an experiment was designed to investigate the
effects of spore concentrations and temperatures of storage
and incubation on spore germination. Three sporophores of
‘Q. gigantea all collected from the same location and on the
same day were selected for this purpose. The dried
peridia and dark gleba of these sporophores indicated that
all of them were mature. One sporophore (#14008) was stored
at 26°C, a second (#1400F) was stored at 12°C and the third
puffball (#1400C) was kept at -l8°C. These 3 sporophores
were stored at these temperatures for 2 months before the
germination experiment.
Six spore concentrations ranging approximately from
1.0 to 20.0 X 106 spores per ml were prepared from each of
the three sporophores and seeded in malt extract agar which
was inoculated with R.M. yeast. Plates were incubated at
20, 24, 28, and 32°C.
Effect of Incubation Temperature
The germination results with spores of sporophores
45
#1400C. 1400F, and 14003 at 20, 24, 28 and 32°C incubation
are recorded in Table 4. Very few spores from the latter
two sporophores germinated. The effect of incubation tempera-
tures on spore germination of Q. gigantea #1400C indicates
that the incubation temperature of 24°C resulted in the
greatest germination per million. Fewer spores germinated
at 20 and 28°C incubation. No germination was recorded at
32°C.
To more precisely define the incubation temperature
for spore germination (#1400C) an additional experiment was
set up in which plates were incubated at 24, 26, and 28°C.
In this experiment a spore concentration of 4.7 X 106 per
dish was seeded into malt extract agar and inoculated with
R.M. yeast. After 8 weeks incubation at 24, 26, and 28°C
respectively, germination rates were 3.6, 3.8, and 1.4 per
million. These results tended to support those of the
previous experiment and suggest that 24-26°C is the most
suitable for germination of spores from Q. gigantea #1400C
(Fig. 3).
Effect of Spore Concentration
The effect 6 spore concentrations from puffballs
stored at 3 different temperatures had on germination is
recorded in Table 4.
Only 1 spore from sporophore #14008 germinated out
of the ten replicate plates seeded with 2.5 X 106 spores
46
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48
and incubated at 20°C.
In the case of spores from the sporophore #1400F
germination occurred only when the spore concentration per
dish was 3.7 X 106 spores or greater.
The greatest number of Spores germinated from sporophore
#1400C which was stored at -l8°C. Figure 4 shows the effect
on germination of spore concentration. At 20, 24, or 28°C
incubation the greatest number of spores from sporophore
#1400C germinated when approximately 5 million spores were
present in each Petri dish. As the spore concentration
increased above this amount the germination rate decreased
until it was negligible at a concentration of 26.0 X 106
spores per dish. This data suggests that increased spore
concentrations inhibit spore germination. However, since
germination per million was determined by the number of
visible colonies, it is possible that at higher spOre concentra-
tions small, invisible colonies might be produced (although
microscopic examination of such plates did not reveal any
minute colonies).
The fact that below a spore concentration of 4.5 X 106
spores per dish the number of spores that germinated decreased
was studied further 7 months later. At that time, 40 plates
of malt extract agar were seeded with spores (2.0 X103)
from sporophore #1400C. Ten additional dishes, each containing
5.2 X 106 spores, were prepared. All plates were inoculated
with R.M. yeast and incubated at 26°C. The results showed
49
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50
that 14.4 spores per million germinated in the control dishes
containing 5.2 X 106 spores. In the dishes each containing
2.0 X 103 spores, only 1 colony was observed. Since a
total of 160 X 103 spores had been tested in these plates.
the germination rate was approximately 6 spores per million.
This data supported the previous experiment showing at least
for spores from Q. gigantea #1400C. there was a decrease in
germination as the spore concentration decreased below 4.6
X 10° per dish.
In subsequent germination experiments using spores
from 15 sporophores stored from 7 to 33 months at three
temperatures (Table 3, 26°C) the germination rate also was
affected by spore concentration. With spores from sporophore
#1400C, after 9 months storage at —18°C a greater germination
rate was observed at a spore concentration of 5.2 X 106
than at 3.5 X 10°. However, the greatest number of spores
to germinate from other sporophores (germinated at similar
storage temperatures and time intervals) was when the
concentration was between 1 and 3 million spores per Petri
dish. Furthermore, the "ideal" concentration varies from
one sporophore to another. This number may even change as
the germination rate increases within a specific sporophore.
For the most part, concentrations of 1-5 million
spores per dish results in the best germination rate.
51
Effect of Storage Temperature
The effect of the three storage temperatures on the
germination of 3 puffballs is compiled in Table 4.
V Only one spore germinated from sporophore #1400B
which had been stored at room temperature for 2 months.
The greatest number of spores that germinated from
sporophore #1400F which had been stored at 12°C for 2 months
was 0.2 per million inoculated. For the most part a
germination rate of < 0.1 spores per million was recorded
from this sporophore.
Of the spores stored at -18°C for 2 months the
greatest germination per million was 3.39 spores. By far, more
spores stored at -18°C germinated than when stored at 12°C
or room temperature.
Seven to 10 months later it was decided to retest
spore germination from some of the previously tested
sporophores and also to attempt spore germination of other
sporophores that had been stored at various temperatures for
several months. Data from these experiments is recorded
in Table 3 (26°C). Spore germination ability was maintained
for spores stored at 12°C and -18°C. One sporophore had
been divided into two pieces when collected. One half
(#1390A) was stored at room temperature and from 12.6 to
94.1 spores germinated per million. The other half of this
sporophore (#1390AF) was stored at 12°C, and from 34.7 to
83.3 spores germinated per million. However, some spores
52
stored at room temperature germinated well.
In most cases it appears that storage at either 12°C
or -l8°C results in the greatest number of spores germinated.
Effect of Storage Intervals
The spores from some sporophores were germinated
after varying lenghts of storage (Table 3). When spores
from sporophore #1390AF were stored an additional 6—7 months
the number of spores that germinated increased 3 to 8 fold.
Spores from #1391B did not germinate after 2 months storage
yet 280.0 spores per million germinated after 7 months'
storage. Additional storage periods also increased the
number of spores that germinate from sporophores #1390A
and #1391A.
These data indicate that for many of the sporophores
tested, the spores require an after-ripening period. The
extent of storage time required for the greatest spore
germination to occur has not as yet been ascertained;
however, 8-14 months appears to be optimal for spores from
some of the sporophores although this varies from one sporophore
to another.
All the data relating to spore concentration and
storage conditions indicates that individual sporophores,
or groups of sporophores, may vary in their specific require-
ments for germination. It was interesting to note that
Snell (1922) stated in reference to wood destroying
53
.Basidiomycetes, "it is possible that spores collected from
different fruit bodies of the same species of different
degrees of maturity, from different climatic conditions and
under different conditions of casting might give varying per
cent values (in germination)."
Other Spore Storage Methods
Two attempts were made to determine if spores of Q,
gigantea could be stored other than in the intact sporophore.
(a) Plates of malt extract agar seeded with spores
from sporophore #1400C (concentration of 4.8 X 106 per dish)
were divided into 4 groups: (1) inoculated with R.M. yeast
24 hours later; (2) stored at -18°C for 17 days, removed,
and inoculated with R.M. yeast; (3) stored at -18°C for 24
days, removed and inoculated with R.M. yeast: (4) stored at
-18°C for 38 days, removed and inoculated with R.M. yeast.
The only spores to germinate were those which had not been
stored at -18°C in malt extract agar.
(b) Aliquots of a spore suspension (#1400C at spore
concentration of 3.5 per ml) containing 20 ppm Chloromycetin
were stored in sterile polyethylene bottles at 26, 10, or
-18°C. At intervals of 5 and 7 months, samples were removed
from all bottles and tested for germination in malt extract
agar plus R.M. yeast. Only in one instance did germination
occur. After 5 months storage at -l8°C only 1 spore out of
5 million germinated: moreover, bacterial contamination was
54
extensive in all plates.
Both of the above techniques failed as a method of
storing #1400C spores.
Effect of Inverted Petri Dishes
In some experiments a few Petri dishes were inverted.
When the number of colonies in these plates was eventually
determined the germination was slightly less than in the
upright plates.
In a more controlled approach to this problem, 20
Petri dishes were incubated inverted and 20 upright. All
these plates were seeded with spores from sporophore #1400C
(stored at -l8OC for 9 months) at a concentration of 3.5
X 106 spores per dish. After 8 weeks incubation the upright
plates had 20.0 colonies per million of g. gigantea as
opposed to 15.0 per million in the inverted Petri dishes.
The reason for this depression of germination is not understood.
Manometric Studies
Throughout these germination investigations the
author attempted to find some quick method by which germina-
tion potential of the spores in a given sporophore could be
determined.
Since dehydrogenase activity could not be detected
with a 1% solution of 2, 3, 5-triphenyltetrazolium Chloride,
several attempts were made to correlate oxygen uptake by
spores with germination rate.
55
In a series of three separate experiments an RQ of
0.5 was obtained for spores from g. gigantea #1400C. This
figure was similar when calculated from the total number of
spores per flask or when converted to one billion spores.
An R0 of this magnitude indicates that the spores might be
metabolizing lipid while in the dormant state.
In several studies the endogenous oxygen uptake by
various spores fluctuated between 30 and 65 micro liters
per one billion spores after 2 1/2 hours. There appeared
to be no correlation between this and the germination ability
of spores from a specific sporophore.
Attempts to increase the oxygen uptake by additions
of 10 concentrations (0.001 to 2.0%) of glucose or succinate
gave erratic data.
Studies were undertaken comparing oxygen uptake by
spores with spores autoclaved 20 minutes at 121°C and 15
pounds pressure. Autoclaved spores recorded an oxygen
consumption of 25—35 micro liters per 1 billion spores;
however, spores treated in 40% formalin for one hour did not
take up oxygen.
In all these studies 2 ppm of Chloromycetin
was used, and since no lag phase was observed it was decided
that the erratic data was not a result of bacterial contamination.
Sexuality of C. gigantea
The mycelium of g. gigantea which produces the tumor-
56
retarding agent(s) was originally derived from the tertiary
mycelium in the gleba of immature sporophores (Stevens, 1957).
When spore germination in liquid media was achieved it became
important to know whether or not the mycelium arising from
spore germinations was of the primary or secondary type.
Should this mycelium be primary then matings would be
necessary to produce secondary mycelium. If, however, the
secondary mycelium were present then perhaps strahs were
already on hand that could produce the oncostatic principle(s).
These questions became one of basic sexuality, e.g..
is g, gigantea a "homothallic" or a "heterothallic" fungus.2
Whitehouse (1949b) indicated that of the 230 species
of Hymenomycetes and Gasteromycetes investigated only 10%
were homothallic. He also reported that none of the species
from the Lycoperdales had been investigated in this respect.
Bessey (1950), in reference to the Gasteromyceteae spores.
said, "These are almost always at first uninuCleate but in.
most of the few cases studied they early become binucleate
by the division of the original nucleus. Whether such binucleate
spores give rise to the dicaryon phase of mycelium is not
'proved, but seems probable." Bessey believed that except
for karyogamy in the young basidium sexual reproduction is
practically unknown in these fungi.
2A homothallic fungus is capable of completing its life
cycle from a single spore. Karyogamy is alternated with
meiosis without the necessity of plasmogamy between mycelia
derived from the germination of an other(s) spore. "Hetero—
thallism," unlike homothallism, requires plasogamy between
mycelia derived from the spore germinations of two spores of
opposite sexes.
57
Fries believed that the Lycoperdon EE- which he had
investigated from 1940—1943 were homothallic although he did
not publish his opinions owing to the 1aCk of positive proof
(personal communication, 1959).
A series of experiments was conducted in attempts to
clarify this question of sexuality. As soon as spore
germination of g, gigantea was accomplished in broth on shakers
an additional 40 flasks were inoculated with spore material
from sporophore #995 and placed on the reciprocal shaker for
8 weeks. Isolates were taken from over 200 of the mycelial
pellets and inoculated into slants of Medium A. Cultures gave
slight variations of color and growth characteristics. Some
were dark brownand others were pale tan. Between these 2
extremes there existed 2 or 3 color intermediates. Some of
the cultures grew in a more heaped up fashion in the center.
Similar color variations were observed later in
cultures derived from spore germinations in malt extract‘
agar. Plate VII shows the variations.
Over a three year period Stevens (personal communication)
removed mycelial isolates from approximately 1000 immature
lg. gigantea sporophores. These exhibited at least 8
distinct growth patterns including color and morpholigical
variations. From each fruit body he removed mycelium from
5 different areas of the gleba. The resulting cultures from
a single sporophore were almost always uniform in color--
only rarely did variations occur.
58
Plate VII. Cultures grown for 3 weeks on slants
of medium A. Note color variations.
These cultures were derived by
germinating the spores of g. gigantea
#1390A in malt extract agar inoculated
with the R.M. yeast.
.4423
Eli?“
59
Comparing the uniformity of the colonies derived
from immature sporophores with the variations observed in
cultures from spore germinations suggests that colonies
derived from germinated spores could be different.
Attempts were made to mate cultures derived from
spore germination of sporophore #995 in barley extract broth.
Ninety-five combinations of the variously colored cultures
were used. In only one instance was plasmogamy observed
between two isolates. In this case no different appearing
mycelium was observed as a result of this union. This was
considered to be plasmogamy at the somatic level--not as a
sign of heterothallism. In the other cases, where plasmogamy
was not observed. the myCelia seldom grew together extensively.
(a) Fruiting Attempts
Several attempts to fruit Q. gigantea were made
with cultures obtained by germinating the spores in barley
broth. Three media (all containing 50 ppm Chloromycetin) were
tested in the investigation: medium A agar, malt extract
agar and medium A broth. Seventy-five and 100 ml amounts
of these solid media were poured into 250 and 500 ml Erlenmyer
flasks respectively. In several instances mycelium from only
one culture was inoculated into each flaSk. On other
occasions as many as eight transfers from spores that had
been germinated from different sporophores were placed into
one flaak. In all cases, after 8 months incubation at 26°C
60
no signs of fruiting could be observed. These cultures had
heaped up somewhat at the original point of transfer. The
cultures from spore germinations of different sporophores
did not completely grow together. As each culture approached
the other it appeared to slow down in growth, possibly as a
result of nutritional competition, or inhibitory metabolic
products.
Mycelium from spore germinations in barley extract
broth of four different g, gigantea sporophores was inoculated
into a 6 liter flask containing 5 inches of sterilized soil
which had been collected from the exact location where aIQ.
gigantea sporophore had grown the previous year. Delivery
tubes were inserted into this large flask in such a manner
that Medium A broth could be siphoned into it or drawn off
for disposal. This semi-constant-flow apparatus was maintained
at room temperature (av. 26°C). The cultures of g, gigantea
grew vigorously in the soil. Very little mycelium remained
on top of the soil but large amounts of mycelium grew down to
the bottom of the flask. At 2 week intervals approximately
100 ml of Medium A broth was flushed into the flaSk to main-
tain a 1/2 inch level in the bottom of the flask. Each
month all the broth was drawn off and fresh broth was added.
In these conditions pure cultures of g, gigantea were grown
for 8 months. No signs of fruiting were seen.
No fruiting experiments were made using Q. gigantea
mycelium derived from the spore germinations in malt extract
61
agar. However, on occasion, mycelium from single cultures
were transferred into plates containing malt extract agar.
After 2, and 4 months incubation (26°C) a great many
Chlamydospores were observed in most cultures. In some
instances these formations were club shaped (appearing similar
to basidia found in the gleba of g, gigantea) but for the
most part they were rounded to oval (Plate VIII). Occasionally
swellings at the hyphal tips were seen. At first they .
were taken for young microconidia (or oidia?). However, on
further examination septations could never be seen between
this swelling and the hypha proper. These were thought to
be young terminal Chlamydospores (Plate VIII).'
(b) Nuclear Condition
Preliminary attempts to stain the nuclei of g, gigantea
mycelium resulting from spore germination were unsatisfactory.
Some of the stains tried were aceto-carmine, aceto-orcein.
giemsa and haemotoxylin. Basidiospores and mycelium (from
spore germination in malt extract agar plus R.M. yeast)
treated with the Fuelgen method gave excellent nuclear
staining (confirmed by G. B. Wilson, Mdchigan State University).
The spores of g, gigantea appear to be binucleate (Plate IXa).
Each nucleus was less than 1 micron in diameter.
The mycelia appear to be binucleate (Plate IXb) or
possibly multinucleate. Owing to the fineness of the mycelium.
its interwoven nature and the distance between septa it was
w‘ .1 '
Plate VIII. Chlamydospores in mycelium which
was derived from germinated spores
of g. gigantea.
63
PLATE IXa. Dikaryotic basidiospores of Q. gigantea.
PLATE IXb. Nuclei in hyphae of g. gigantea the mycelium
of which was derived from spore germination.
64
difficult to find complete cells. However, two nuclei were
associated quite close together and it appeared that the
cells were binucleate. This data suggests that the secondary
mycelium is derived from germinating spores.
Antifungal Properties of C. gigantea
The results of evaluating strains of g, gigantea for
antifungal activity by inoculating Glomerella cultures are
shown in Table 5. When grown on killed cultures of g.
cingulata, no evidence of antifungal activity was observed
with any of the Calvatia strains tested. In the case of
killed cultures, antifungal activity was determined by
measuring the lytic zone. Antifungal activity was demonstrated
by Calvatia strains when inoculated onto the surface of
Glomerella which had been growing for 12 hours (Plate X).
In Table 5 strains isolated from immature sporophores of
Calvatia, #995 to #1369, showed greater antifungal activity
against Glomerella mycelium than strains that developed
from germination of Q. gigantea #995 spores (numbers A1-2
to A15-8). When strains of Q..gigantea were placed on plates
of Glomerella grown for 4 days, only 3 of these had produced
zones of inhibited growth, of which Ad5—8 was the most effective.
When these zones were tested with pH indicator paper it was
evident that this phenomenon is not a function of hydrogen
ion concentration.
When attempts were made to reproduce these results 4
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