"Proteins undergo constant proteolytic degradation to regulate intracellular processes and maintain biological homeostasis. One of the main intracellular proteolytic pathways involves the proteasome, which is responsible for the degradation of misfolded, oxidatively damaged, and redundant proteins. The age-related decline of the efficiency of this enzymatic pathway leads to accumulation of aberrant proteins which leads to aggregates and a host of amyloidosis disease states. Small molecule intervention has been suggested as a viable therapeutic strategy; however, enhancement of proteasome activity is not well understood. This work details efforts and evidence for mechanistic understanding of how small molecule action may enhance and bias proteasome proteolysis and provides a theoretical model for further advancement."--Page ii.
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