Nitrogen containing compounds, such as isoxazoles, enamines, amines, and a variety of heterocycles have incredible values and potentials in pharmaceutical industry.1 These compounds are prevalent in many pharmaceuticals, organic dyes, solar cells, and natural products. However, conventional pyridine syntheses often have limitation, such as limited substrate scope, low regioselectivity, or harsh reaction conditions. Therefore, new synthetic routes into these nitrogen containing compounds are highly desirable. Our group has been exploring synthetic routes using titanium metal reagents or catalysts to synthesize a wide variety of nitrogen containing compounds. One of the synthetic routes developed in our group is titanium-mediated pyridine synthesis via inverse electron-demand hetero-Diels-Alder reaction (Chapter 2). Also, our group previously developed a tool to help us evaluate ligand effects to high valent metal, and with this tool we have been exploring and developing new asymmetric ligands for titanium catalysts (Chapter 3).
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