Surfactant analysis is generally performed using liquid chromatography (LC) and a tandem triple-quadrupole mass spectrometer (MS-MS). This method provides the sensitivity and specificity required to resolve this type of molecule in a mixture. A less equipped laboratory may not have this option. Here we show a method developed to detect residual quantities of the surfactant Reasoap SR-10 in emulsion polymer samples. This was achieved using an Acclaim Surfactant Plus column from Thermo Scientific installed on a Waters 2695 liquid chromatograph connected to a Waters QDa single quadrupole mass detector set for single ion recording at m/z = 557, utilizing electrospray ionization. While specificity was achieved, the method had challenges with consistent sensitivity, precision and recovery which will lead to more effort in method refinement, namely sample preparation. Even though for now it is better classified as a qualitative method, a fully successful method would be a benefit for our laboratory. This would prevent causing delays for needed information and higher costs due to utilizing a reference laboratory, creating efficiencies for in-house product troubleshooting as well as research and development.
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