Stereoselective glycosylations and synthesis of hyaluronan biosynthesis inhibitors
ABSTRACTSTEREOSELECTIVE GLYCOSYLATIONS AND SYNTHESIS OF HYALURONAN SYNTHESIS INHIBITORSByGilbert Ochieng WasongaStereochemical control is an important issue in carbohydrate synthesis. Glycosyl donors with participating acyl protective groups on 2-O have been shown to give 1,2-trans glycosides reliably under the pre-activation based reaction condition. In this work, the effects of additives and reaction solvent on stereoselectivity was examined using donors without participating protective groups on 2-O. We have established that the stereoselectivity could be directed by reaction solvent. The trend of stereochemical dependence on reaction solvent was applicable to a variety of reactions including the selective formation of -mannosides. In the second part, 3-MeO-GlcNAc is efficiently prepared using a furanose oxazoline intermediate which is well suited for large scale synthesis without the need for extensive column chromatography. In addition, we have developed a robust and rapid procedure for the synthesis of 3-F-GlcNAc derivative required for inhibition studies of hyaluronan biosynthesis. In the course of our synthesis, we have shown the expanded utility of Lattrell-Dax method for carbohydrate epimerization reactions.
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- In Collections
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Electronic Theses & Dissertations
- Copyright Status
- In Copyright
- Material Type
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Theses
- Authors
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Wasonga, Gilbert Ochieng
- Thesis Advisors
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Huang, Xuefei
- Committee Members
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Borhan, Babak
Wulff, William
Blanchard, Gary
- Date
- 2010
- Program of Study
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Chemistry
- Degree Level
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Masters
- Language
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English
- Pages
- xvi, 189 pages
- ISBN
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9781124362953
1124362959
- Permalink
- https://doi.org/doi:10.25335/514n-3h77