You are here
Search results
(61 - 80 of 432)
Pages
- Title
- ADDITIVE MANUFACTURING FOR RAPID PROTOTYPING OF MM-WAVE CIRCUITS
- Creator
- Crump, Cameron Austin
- Date
- 2021
- Collection
- Electronic Theses & Dissertations
- Description
-
Additive manufacturing (AM) has recently attracted significant interest to meet the need of nextgeneration of wireless systems, and the growing demand for customization and rapid prototyping of electronic systems. In addition, AM is being investigated to supplement and in some cases replace traditional microelectronic fabrication techniques. This is to lessen the ecological impact of electronics manufacturing as well as to reduce cleanroom facility costs. This research work focuses on the use...
Show moreAdditive manufacturing (AM) has recently attracted significant interest to meet the need of nextgeneration of wireless systems, and the growing demand for customization and rapid prototyping of electronic systems. In addition, AM is being investigated to supplement and in some cases replace traditional microelectronic fabrication techniques. This is to lessen the ecological impact of electronics manufacturing as well as to reduce cleanroom facility costs. This research work focuses on the use of AM for the design and fabrication of microwave and millimeter wave components and systems, leading to heterogeneous integration. For systems integration, two major challenges to tackle are: (1) rapid printing of conductive regions with high precision and high conductivity; (2) selective deposition of dielectrics with varying geometries surrounding active and passive components. In this work, printing of both conductors and dielectrics was carried out using aerosol jet printing (AJP). AJP allows for high resolution printing (~10 μm) at a large standoff distance (~10 mm). Silver (Ag) based inks were investigated to achieve high conductivity and polymers (benzocyclobutene, BCB and Polyimide, PI) as low-loss dielectric materials.
Show less
- Title
- AGGREGATE PLANNING IN MANUFACTURING OF REUSABLE CONTAINERS
- Creator
- Tao, Jinli
- Date
- 2021
- Collection
- Electronic Theses & Dissertations
- Description
-
Aggregate production planning (APP) is a method to make several decisions simultaneously on production, inventory, and workforce levels over a finite time horizon, aiming to maximize the profit or minimize the cost while meeting fluctuating demands. Building mathematical models that reflect real-world problems is often difficult, as the constraints are usually intricate and may interact with each other. Decomposing the interconnected system into a number of independent phases could simplify...
Show moreAggregate production planning (APP) is a method to make several decisions simultaneously on production, inventory, and workforce levels over a finite time horizon, aiming to maximize the profit or minimize the cost while meeting fluctuating demands. Building mathematical models that reflect real-world problems is often difficult, as the constraints are usually intricate and may interact with each other. Decomposing the interconnected system into a number of independent phases could simplify the problem; however, it may not guarantee the optimality of the best solutions due to the missed constraints between stages. In this study, two mixed integer programming models for the manufacturing of reusable plastic containers are presented. One is based on the flow of the material and the other is based on the level of the workforce at each period. The proposed models are able to (i) deal with varying demand, (ii) reflect various regulations and restrictions of public and private warehouses for storing materials, and (iii) identify the importance of subcontracting when demand increases dramatically. Both mathematical models are implemented in the case of packaging manufacturing. A comprehensive sensitivity analysis has been conducted on different parameters of the problem to test the effect of parameter changes. To sum up, the general framework of the mathematical models not only can be used for reusable container manufacturing but also the manufacturing of any type of product with a similar supply chain network.
Show less
- Title
- AN EVOLUTIONARY MULTI-OBJECTIVE APPROACH TO SUSTAINABLE AGRICULTURAL WATER AND NUTRIENT OPTIMIZATION
- Creator
- Kropp, Ian Meyer
- Date
- 2018
- Collection
- Electronic Theses & Dissertations
- Description
-
One of the main problems that society is facing in the 21st century is that agricultural production must keep pace with a rapidly increasing global population in an environmentally sustainable manner. One of the solutions to this global problem is a system approach through the application of optimization techniques to manage farm operations. However, unlike existing agricultural optimization research, this work seeks to optimize multiple agricultural objectives at once via multi-objective...
Show moreOne of the main problems that society is facing in the 21st century is that agricultural production must keep pace with a rapidly increasing global population in an environmentally sustainable manner. One of the solutions to this global problem is a system approach through the application of optimization techniques to manage farm operations. However, unlike existing agricultural optimization research, this work seeks to optimize multiple agricultural objectives at once via multi-objective optimization techniques. Specifically, the algorithm Unified Non-dominated Sorting Genetic Algorithm-III (U-NSGA-III) searched for irrigation and nutrient management practices that minimized combinations of environmental objectives (e.g., total irrigation applied, total nitrogen leached) while maximizing crop yield for maize. During optimization, the crop model named the Decision Support System for Agrotechnology Transfer (DSSAT) calculated the yield and nitrogen leaching for each given management practices. This study also developed a novel bi-level optimization framework to improve the performance of the optimization algorithm, employing U-NSGA-III on the upper level and Monte Carlo optimization on the lower level. The multi-objective optimization framework resulted in groups of equally optimal solutions that each offered a unique trade-off among the objectives. As a result, producers can choose the one that best addresses their needs among these groups of solutions, known as Pareto fronts. In addition, the bi-level optimization framework further improved the number, performance, and diversity of solutions within the Pareto fronts.
Show less
- Title
- AN EXPLORATORY TEST OF FAR-RIGHT EXTREMISTS PROTECTIVE AND PUTATIVE (RISK) FACTORS; IN BOTH VIOLENT AND NON-VIOLENT OFFENDERS USING THE EXTREMIST CRIME DATABASE
- Creator
- Lindsay, Lance Jhordan Asquith
- Date
- 2021
- Collection
- Electronic Theses & Dissertations
- Description
-
ABSTRACTAN EXPLORATORY TEST OF FAR-RIGHT EXTREMISTS PROTECTIVE AND PUTATIVE (RISK) FACTORS; IN BOTH VIOLENT AND NON-VIOLENT OFFENDERS USING THE EXTREMIST CRIME DATABASEByLance Jhordan Asquith. LindsayResearch in the field of extremism studies have steadily progressed as it emerged from the main field of terrorism studies. This progression has gone from defining terrorism and its root causes; to measuring cognitive and behavioral indicators which may predict the likelihood of radicalization...
Show moreABSTRACTAN EXPLORATORY TEST OF FAR-RIGHT EXTREMISTS PROTECTIVE AND PUTATIVE (RISK) FACTORS; IN BOTH VIOLENT AND NON-VIOLENT OFFENDERS USING THE EXTREMIST CRIME DATABASEByLance Jhordan Asquith. LindsayResearch in the field of extremism studies have steadily progressed as it emerged from the main field of terrorism studies. This progression has gone from defining terrorism and its root causes; to measuring cognitive and behavioral indicators which may predict the likelihood of radicalization toward extremism. This comes after tedious debates about typology and causes of terrorism in the field, there are still challenges to overcome as most research relies on open-source data. Through efforts to make this field more established the Extremist Crime Database (ECDB) stands out as a standard for this pursuit having some of the best open-source data and widespread usage. The database captures extremist violence from 1990 to 2014 and is a relational database that links event level data to individual offender level data. This database created by Freilich and colleagues (2014) has resulted in the ability to conduct quantitative analysis beyond descriptive statistics. The main question: are there differences in these risk and protective factors that lead to non-violent or violent outcomes of offenders in this sample? These nuances in the frequency of factors may explain why an individual followed the offending trajectory and if these differences explain offending.
Show less
- Title
- ASSESSING REPRODUCTIVE SUCCESS OF LAKE STURGEON (ACIPENSER FULVESCENS) ASSOCIATED WITH NATURAL AND CONSTRUCTED SPAWNING REEFS IN A LARGE RIVER SYSTEM USING PEDIGREE ANALYSIS
- Creator
- Hunter III, Robert D.
- Date
- 2018
- Collection
- Electronic Theses & Dissertations
- Description
-
Habitat modification including barriers to migration, poor water quality, and modification of benthic habitat has contributed to the decline of lake sturgeon (Acipenser fulvescens) abundances in the Great Lakes. Lack of habitat was identified as a limiting factor for lake sturgeon recovery in the St. Clair-Detroit River System (SCDRS). To increase habitat availability in the SCDRS with the intent of increasing lake sturgeon populations, seven spawning reefs were constructed. Using 741 eggs...
Show moreHabitat modification including barriers to migration, poor water quality, and modification of benthic habitat has contributed to the decline of lake sturgeon (Acipenser fulvescens) abundances in the Great Lakes. Lack of habitat was identified as a limiting factor for lake sturgeon recovery in the St. Clair-Detroit River System (SCDRS). To increase habitat availability in the SCDRS with the intent of increasing lake sturgeon populations, seven spawning reefs were constructed. Using 741 eggs and larvae collected during traditional assessments, genetic pedigree analysis was used to further quantify spawning habitat use. In 2015 and 2016, 339-349 spawners were estimated to have contributed offspring across all sites. The effective number of breeders was estimated at 295-314 spawners, with mean (4.26-4.37 larvae) and variance (6.26-7.20) in individual reproductive success across all reefs and in 2015 and 2016. Evidence of adults spawning at multiple reefs within and between rivers was revealed by shared sib-ship of offspring collected at multiple locations. Comparison between gear types revealed that differences in the way individuals are collected can affect estimates generated from genetic pedigree analysis. Finally, species richness estimators were combined with genetic pedigree analysis to estimate the total number of spawners contributing offspring at constructed reefs (11-92 spawners per reef per year). Detailed information regarding lake sturgeon spawning behavior associated with spawning habitat construction in the SCDRS informs future assessment and management action for conservation of lake sturgeon throughout their range.
Show less
- Title
- Absorption spectra of certain dyes in the visible and ultraviolet
- Creator
- Leach, Melvin Arthur
- Date
- 1927
- Collection
- Electronic Theses & Dissertations
- Title
- Achromatic variations in pathogenic fungi
- Creator
- Caldis, Panos D.
- Date
- 1925
- Collection
- Electronic Theses & Dissertations
- Title
- Acid tolerance of strawberry plants
- Creator
- Morris, Laval S.
- Date
- 1926
- Collection
- Electronic Theses & Dissertations
- Title
- Addressing the news media image in an age of skepticism
- Creator
- Shin, Soo Young
- Date
- 2018
- Collection
- Electronic Theses & Dissertations
- Description
-
As the public’s skepticism toward news media has been growing, we need to better understand how the public perceives news media organizations. This study employed a useful conceptual lens from the marketing literature, image, to build a new conceptual framework within journalism, news media image to in aid in this understanding. Using focus group interviewing methods, the perceptions of 44 participants (across nine sessions) living in the Midwest in the U.S. were investigated to reveal the...
Show moreAs the public’s skepticism toward news media has been growing, we need to better understand how the public perceives news media organizations. This study employed a useful conceptual lens from the marketing literature, image, to build a new conceptual framework within journalism, news media image to in aid in this understanding. Using focus group interviewing methods, the perceptions of 44 participants (across nine sessions) living in the Midwest in the U.S. were investigated to reveal the news media image constructs perceived by the public. Through multidisciplinary literature review and group discussions, eight dimensions emerged: news quality, news usefulness, socially responsible, personality, usability, transparent, perspective-taking, and news selection bias. Results showed that participants believed that news media organizations are mostly unreliable and biased in selecting news worthy stories as the news organizations are under the pressure of making profit or political interests. However, the information provided by news organizations was regarded as being useful in getting relevant information to the participants’ lives and news organizations’ potential role of protecting democracy were valued by participants. Exploring how these dimensions represent people's image of the news media provides insight into the current American’s perceptions and biases toward the news media organizations.
Show less
- Title
- Adhesion mechanics and physical characteristics of Salmonella enteritidis in low moisture environments
- Creator
- Suehr, Quincy Jerome
- Date
- 2020
- Collection
- Electronic Theses & Dissertations
- Description
-
Controlling foodborne pathogens in low-moisture environments requires an understanding of how contamination is introduced and spread through a system. Compared with numerous data and studies regarding wet environments, limited information exists concerning the adhesion mechanics of pathogens in low-moisture environments. Therefore, the objectives of this study were to: (1) Develop a framework for adhesion of bacteria in a low moisture environment, (2) perform direct measurements of adhesion...
Show moreControlling foodborne pathogens in low-moisture environments requires an understanding of how contamination is introduced and spread through a system. Compared with numerous data and studies regarding wet environments, limited information exists concerning the adhesion mechanics of pathogens in low-moisture environments. Therefore, the objectives of this study were to: (1) Develop a framework for adhesion of bacteria in a low moisture environment, (2) perform direct measurements of adhesion mechanics, (3) implement measurements into a model, and (4) validate the model. Physical properties and adhesion characteristics of Salmonella Enteritidis PT30 (SE PT30) attached on stainless steel 304 were assessed by Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM), and used to develop a Discrete Element Method (DEM) model as a first principle based approach. This model allowed the estimation of force of reversible adhesion for Salmonella Enteritidis PT30 to be measured as Fad = 3.3459 ± 0.0283 nN. For model validation, a large-scale bacterial detachment experiment utilizing Salmonella was conducted. The modeling results for adhesion was able to elucidate bacterial adhesion mechanics, and the cross-contamination phenomena in low-moisture environment.
Show less
- Title
- Adsorption media for the removal of phosphorus in subsurface drainage for Michigan corn fields
- Creator
- Hauda, Jessica Kathleen
- Date
- 2020
- Collection
- Electronic Theses & Dissertations
- Description
-
Phosphorus is a valuable, non-renewable resource in agriculture promoting crop growth. and is used in the global food chain, mainly as fertilizer. Soluble phosphorus plays a part in the eutrophication in freshwater environments, which impacts tourism, human health, environmental safety, and property values. Phosphorus loss from agricultural land is also a loss of investment that went into keeping it on the soil, and its addition into water bodies can increase costs to manage the affected area...
Show morePhosphorus is a valuable, non-renewable resource in agriculture promoting crop growth. and is used in the global food chain, mainly as fertilizer. Soluble phosphorus plays a part in the eutrophication in freshwater environments, which impacts tourism, human health, environmental safety, and property values. Phosphorus loss from agricultural land is also a loss of investment that went into keeping it on the soil, and its addition into water bodies can increase costs to manage the affected area(s). This research entails selecting the phosphorus adsorption media best suited for removing phosphorus from subsurface drainage in Michigan farms. Selected adsorption media from the literature includes engineered nanomaterials, biochar, and natural materials. These media were evaluated with typical subsurface drainage phosphorus concentrations using batch adsorption and column experiments to verify if the media worked in this application. Both the steel furnace slag (SFS) and PO4Sponge removed soluble reactive phosphorus from 0.500 to below 0.05 mg/L in column experiments at an empty bed contact time of 5-minutes The SFS was the most cost-effective option based on a case-study and generalized analysis. The most expensive option was the use of PO4Sponge media to remove phosphorus, then regenerating it at the manufacturer.
Show less
- Title
- Affective aesthetics and the social politics of Neoliberalism in New Extremism cinema
- Creator
- Clark, Cameron
- Date
- 2017
- Collection
- Electronic Theses & Dissertations
- Description
-
This thesis investigates the aesthetics of transgression in New Extremism cinema for the ways in which they inform, and are mutually informed by, neoliberal affect and social politics. Although negative affect and spectatorial embodiment are often central to critical discourse on New Extremism, this thesis instead attends to the interlocking aesthetic, narrative, and spatio-temporal expressions of affect as they correlate with neoliberal politics of respectability and reproduction. By...
Show moreThis thesis investigates the aesthetics of transgression in New Extremism cinema for the ways in which they inform, and are mutually informed by, neoliberal affect and social politics. Although negative affect and spectatorial embodiment are often central to critical discourse on New Extremism, this thesis instead attends to the interlocking aesthetic, narrative, and spatio-temporal expressions of affect as they correlate with neoliberal politics of respectability and reproduction. By deploying feminism and queer theory, this thesis locates positive, productive potentials within formal expressions of negative affect that mobilize a political critique of the violences within each film. In so doing, the selected film examples--Fabrice Du Welz's Calvaire (2004), Marina de Van's Dans ma peu (2002), Olivier Assayas's Demonlover (2002), Bruno Dumont's Twentynine Palms (2004), François Ozon's Criminal Lovers (2001), Alain Guiraudie's Stranger by the Lake (2014), to name a few--portray the shifting relations between politics, gender, and sexuality in the neoliberal present and offer critical alternatives for how such developments have impacted and impeded sociality.
Show less
- Title
- Agglutination studies
- Creator
- Loomis, Ferne F.
- Date
- 1926
- Collection
- Electronic Theses & Dissertations
- Title
- Alignment between intensity of risk and level of collaboration in partnered architecture, engineering and construction projects : a quantitative approach to test impacts on project performance outcomes
- Creator
- Kalbhor, Harshavardhan Vijay
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
-
Risk is a typical characteristic of Architecture, Engineering, and Construction (AEC) projects due to their inherent complexities. The intensity of such risk is influenced by factors such as the dynamic nature of project elements (e.g., fragmented multi-disciplinary project teams), interactions among these elements, and lack of clear project goals. Project management theory and practice both endorse that as the intensity of risk in a project increases, a higher level of collaboration among...
Show moreRisk is a typical characteristic of Architecture, Engineering, and Construction (AEC) projects due to their inherent complexities. The intensity of such risk is influenced by factors such as the dynamic nature of project elements (e.g., fragmented multi-disciplinary project teams), interactions among these elements, and lack of clear project goals. Project management theory and practice both endorse that as the intensity of risk in a project increases, a higher level of collaboration among the multi-disciplinary project teams is desirable in order to achieve optimal project performance outcomes.To facilitate higher or improved level of collaboration among project teams, the AEC industry utilizes innovative project delivery methods (e.g., IPD), technologies (e.g., BIM), and practices (e.g., Lean Construction). Project Partnering is one such project delivery practice; adopting which, two or more organizations commit to harboring an environment of collaboration (e.g., effective communication, shared vision, goal alignment, trust) in a structured approach, with the intention of achieving optimum shared project performance goals (e.g., reduced costs, delays).Although both researchers and practitioners commonly recognize that collaboration is an effective risk management strategy, a theoretical gap exists in providing empirical reinforcement supporting this assertion. A part of this gap is due to the lack of a structured framework for investigating collaboration. Partnering fulfills this shortcoming and provides a structured framework to study collaboration analytically. Thus, partnered AEC projects are the focus and unit of analysis for this research.In addition, existing Partnering literature is largely qualitative and presents conceptual models, potential benefits to adopting Partnering, barriers to its adoption, critical success factors, and performance measurement and evaluation methods. Quantitative research in this domain is limited and has studied projects either coming largely from a single source of ownership (e.g., DOTs) or a particular project type (e.g., horizontal infrastructure projects) at a time. There is a need for evidence-based quantitative research that identifies specific factors linked to partnered-project success using data from a large and diversified sample of projects.Thus, the need for an empirical assessment of the association (denoted by the variable fit) between risk (specifically its intensity) and level of collaboration (via partnering practices in this study), and its impact on project performance prompted the undertaking of this study. Due to lack of pre-defined terminology to capture the association between risk intensity and partnering level, it was denoted in this study via an introduction of the variable 'fit'. The goal of the study is to investigate partnered AEC projects for the impact of the fit between their intensity of risk and adopted partnering level on their performance outcomes (e.g., cost, schedule). Accordingly, this study aims to answer the following research question: 'In partnered AEC projects, does the fit between risk intensity and level of partnering correlate with performance outcomes?' The hypothesis developed by the researcher is that 'In a partnered project, better the fit between the intensity of risk and adopted partnering level, better is its performance.' This study used an archival data-set containing details of 127 partnered projects from the United States completed between 2010 and 2018. Literature study followed by an exploratory data analysis was conducted to develop models to determine constructs of interest - risk intensity, partnering level and performance evaluation metrics, from AEC project characteristics. The models were validated via a survey; and are one of the outcomes of this study. Further, via content analysis, quantitative measures of these constructs were systematically coded from project details in the data set.The hypothesis of this study was tested separately for different performance outcome metrics (e.g., cost growth, schedule growth) via a quantitative approach of unsupervised statistical learning tests such as the Kruskal-Wallis test and the Dunn Test for comparison of performance metric data as samples across the fit categories. The deliverable of this study are tools or models for risk intensity assessment and simultaneous determination of recommended level of partnering. The study was able to contribute to the body of knowledge of risk management via collaboration by providing empirical reinforcement to the association or lack of thereof between risk, collaboration and performance. Lastly, this study provides guidelines for best practices in Partnering contributing to effective risk management on AEC projects.
Show less
- Title
- American mass shooters and suicide
- Creator
- Brown, Kylei Elizabeth
- Date
- 2018
- Collection
- Electronic Theses & Dissertations
- Description
-
Mass shootings are traumatic events associated with highly publicized and often gruesome homicides that raise public alarm. Yet, researchers know relatively little about shooters and mass shooting events. Therefore, it is important to further extend the research of mass shootings to characterize different types of shooters and how they ultimately perpetrate their attacks. As such, the current study investigated the differences between American mass shooters who commit suicide after their...
Show moreMass shootings are traumatic events associated with highly publicized and often gruesome homicides that raise public alarm. Yet, researchers know relatively little about shooters and mass shooting events. Therefore, it is important to further extend the research of mass shootings to characterize different types of shooters and how they ultimately perpetrate their attacks. As such, the current study investigated the differences between American mass shooters who commit suicide after their attacks and mass shooters who do not. This study examined shooter vitality in 185 mass shootings in America perpetrated by 194 mass shooters between 2000 and 2016. Each shooter was categorized as having survived the attack or the manner in which they died; whether by self-inflicted suicide or being shot by another person. This revised data about how the mass shooters died was compared with thirty-three different independent variables that looked at the characteristics of the mass shooters as well as the characteristics of the mass shootings using both analysis of variance and binary logistic regression analytic techniques. At the same time, an original version of this dataset was tested alongside the revised dataset to look for similarities and comparisons in the results. The results of the revised dataset showed that mass shooters with a prior criminal record are more likely to survive their attacks and those who kill more victims are less likely to survive their attacks. These results are useful to inform both law enforcement personnel intervening in a mass shooting as well as lawmakers developing policies in an attempt to decrease the number of mass shootings in America.
Show less
- Title
- An economic study of the San Jose scale : its allies, history & methods for its extermination
- Creator
- Woodbury, Charles Goodrich
- Date
- 1906
- Collection
- Electronic Theses & Dissertations
- Title
- Analysis of Positional Bias Within Multiple Stimulus Without Replacement Preference Assessments
- Creator
- Miranda, David Ray Gutierrez
- Date
- 2021
- Collection
- Electronic Theses & Dissertations
- Description
-
Positional bias is a pattern of responding to a specific location that can be influenced by response effort and/or prior learning history. Within the contexts of preference assessments, positional bias create additional variables that make ascertaining true preferences within a preference assessment more difficult. Prior research on positional bias within preference assessments have focused primarily on its use in paired stimulus assessments due to the complex nature of the multiple-stimulus...
Show morePositional bias is a pattern of responding to a specific location that can be influenced by response effort and/or prior learning history. Within the contexts of preference assessments, positional bias create additional variables that make ascertaining true preferences within a preference assessment more difficult. Prior research on positional bias within preference assessments have focused primarily on its use in paired stimulus assessments due to the complex nature of the multiple-stimulus without replacement preference assessment. The present study is a secondary analysis that utilized four different methods to measure side bias and center bias for 19 young children with autism spectrum disorders. Results indicate that participants had varying degrees of biased responding but collectively engaged in little biased responding. Present study includes discussion of general patterns of responding, an analysis of the four methodologies, and general recommendations for the application of these methodologies.
Show less
- Title
- Analysis of mice carrying human GNAO1 mutations as a model to study associated movement disorders
- Creator
- Larrivee, Casandra Lynn
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
-
"Due to the increased availability of genetic screening, patients with idiopathic epilepsy and movement disorders are being identified with mutations in the GNAO1 gene. The GNAO1 gene encodes a heterotrimeric G protein subunit, Galphao, abundantly found within the brain. Patients with de novo mutations in GNAO1 specifically may have early onset seizure disorders and/or involuntary movements. These two phenotypes were later classified as early infantile epileptic encephalopathy (EIEE17) and...
Show more"Due to the increased availability of genetic screening, patients with idiopathic epilepsy and movement disorders are being identified with mutations in the GNAO1 gene. The GNAO1 gene encodes a heterotrimeric G protein subunit, Galphao, abundantly found within the brain. Patients with de novo mutations in GNAO1 specifically may have early onset seizure disorders and/or involuntary movements. These two phenotypes were later classified as early infantile epileptic encephalopathy (EIEE17) and neurodevelopmental delay with involuntary movements (NEDIM) respectively. Previous work in our lab uncovered a pattern between the in vitro function of mutations and the type of disorder observed in patients. Loss-of-function mutations associated with EIEE17 while gain-of-function mutations or proteins with essentially normal function were seen in NEDIM. To determine whether this pattern could be replicated in vivo, heterozygous mutant mice were created using CRISPR/Cas9. Here we report the first mouse models of GNAO1 disorders, Gnao1+/G203R and Gnao1+/R209H. Using a variety of behavioral battery tests including open field, rotarod and digigait, we were able to show distinct behavioral patterns between the mutant mice. Using these models we began to explore preclinical drug repurposing and neural mechanisms."--Page ii.
Show less
- Title
- Analysis of slip transfer in TI-5AL-2.5SN (WT. %) at two temperatures in comparison to pure aluminum
- Creator
- Edge, Chelsea M.
- Date
- 2020
- Collection
- Electronic Theses & Dissertations
- Description
-
Understanding the deformation mechanisms present near grain boundaries in polycrystalline hexagonal alloys will aid in improving modeling methods. Ti-5Al-2.5Sn samples were tensile tested at 296K and 728K, and slip behavior was assessed near grain boundaries. From the EBSD measurements of grain orientations, various metrics related to the slip systems, traces, residual Burgers vectors, and grain boundary misorientation were computed for boundaries showing evidence of slip transfer and...
Show moreUnderstanding the deformation mechanisms present near grain boundaries in polycrystalline hexagonal alloys will aid in improving modeling methods. Ti-5Al-2.5Sn samples were tensile tested at 296K and 728K, and slip behavior was assessed near grain boundaries. From the EBSD measurements of grain orientations, various metrics related to the slip systems, traces, residual Burgers vectors, and grain boundary misorientation were computed for boundaries showing evidence of slip transfer and boundaries showing no evidence of slip transfer. This work is compared to a similar study of an Aluminum oligo-crystal to aid in understanding the differences in slip behavior near grain boundaries in HCP and FCC crystal structures. Slip transfer in Ti525 was generally observed in less geometrically compatible conditions than Al, and slip transfer occurs at high misorientation angles in Ti-5Al-2.5Sn much more frequently than in Al.
Show less
- Title
- Analyzing and reducing energy consumption on the Michigan State University campus
- Creator
- Renny, Alexander
- Date
- 2017
- Collection
- Electronic Theses & Dissertations
- Description
-
The reliance on fossil fuels to generate most of the world's energy has led to a significant increase in greenhouse gas emissions and the associated negative effects on the climate. The application of energy reducing retrofits allows for significant reductions in total energy use, providing the opportunity to achieve cost savings as well as emissions reductions. Students Planning Advanced Retrofit Technology Applications (SPARTA) was founded to pursue implementation of these retrofits at...
Show moreThe reliance on fossil fuels to generate most of the world's energy has led to a significant increase in greenhouse gas emissions and the associated negative effects on the climate. The application of energy reducing retrofits allows for significant reductions in total energy use, providing the opportunity to achieve cost savings as well as emissions reductions. Students Planning Advanced Retrofit Technology Applications (SPARTA) was founded to pursue implementation of these retrofits at Michigan State University (MSU). Under this framework, lighting, device, and HVAC retrofits are examined. In commercial spaces, lighting comprises 170303% of total electricity used. The economic viability of retrofitting LEDs in place of fluorescent ceiling fixtures as well as various control methods are determined. The energy use intensity of the average office space on the MSU campus is also analyzed and equipment changes are recommended to decrease the total energy footprint. Conversion from electricity driven cooling to steam driven cooling is evaluated as a method for increasing efficiency of the co-generation power plant and decreasing total fuel consumption. Finally, activities aimed at engaging the public on renewable energy generation are described, which are based on the development of paintable luminescent solar concentrators that combine art and energy. A number of techniques for reducing energy use on the MSU campus have been analyzed which can be applied across a broad spectrum of spaces. Continuing to aggressively pursue the implementation of this framework as well as tracking key economic indicators outlined will ultimately make MSU cleaner and more sustainable. -- Abstract.
Show less