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Title: Techniques and results of applying thiourea to synthetic and grass silage media for the control of Stomoxys calcitrans Linnaeus
Creator: Weinburgh, Harry B.
Date: 1956
Collection: Electronic Theses & Dissertations

Title: A survey study of the metazoan fauna of the psammolittoral zone of Mud Lake, Barry County, Michigan
Creator: Weber, Peter Gotthilf
Date: 1963
Collection: Electronic Theses & Dissertations

Title: River valley lands in Southwestern Ontario
Creator: Weber, Edward J.
Date: 1966
Collection: Electronic Theses & Dissertations

Title: A study of the development and awareness of the need for creative uses of leisure time of high school students in a working class community
Creator: Welch, Gordon R.
Date: 1967
Collection: Electronic Theses & Dissertations

Title: The initial phase of pathogenesis in Victoria blight of oats
Creator: Yoder, Olen C.
Date: 1968
Collection: Electronic Theses & Dissertations

Title: Friction equivalents of take-offs in rectangular ducts
Creator: Yohn, James Harold
Date: 1950
Collection: Electronic Theses & Dissertations

Title: The effect of chain extender on the molecular weight and hydrolytic degradation of poly(lactic acid)
Creator: Limsukon, Wanwarang
Date: 2019
Collection: Electronic Theses & Dissertations
Description: "The effect of chain extender (Cex) on the molecular weight properties and hydrolytic degradation of modified PLA films (PLA--Cex) was determined and compared with PLA without Cex (PLA--Con). Effects of the Cex content and the residence time on the molecular weight were reviewed using melt blending and compression molding. A response surface methodology was applied to design the experiments and estimate the optimal conditions for obtaining the maximum weight average and number average...
Show more"The effect of chain extender (Cex) on the molecular weight properties and hydrolytic degradation of modified PLA films (PLA--Cex) was determined and compared with PLA without Cex (PLA--Con). Effects of the Cex content and the residence time on the molecular weight were reviewed using melt blending and compression molding. A response surface methodology was applied to design the experiments and estimate the optimal conditions for obtaining the maximum weight average and number average molecular weight achieved at 1.5 wt% Cex and residence time of 17 minutes. The hydrolytic degradation experiments were run in water from 40 to 95 °C and in 50% ethanol from 40 to 85 °C. The rate of hydrolytic degradation of PLA--Cex film was estimated using mathematical models, and it was considerably lower than that of PLA--Con in all conditions. The activation energy for hydrolysis above Tg was determined using the Arrhenius equation, showing no significant difference between PLA--Cex and PLA--Con. The Vogel-Tammann-Fulcher (VTF) and the Williams-Landel-Ferry (WLF) models were used for studying the hydrolytic degradation of polymers over a broad range of temperature crossing Tg. A master curve was constructed using the time-temperature superposition principle. The experimental data at 85 °C were used to predict the degradation behavior at 40 °C. It was found that PLA--Cex would take approximately 72 percent more time than PLA--Con to degrade to soluble oligomer chains."--Page ii.
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Title: Therapeutically targeting autophagy in non-small cell lung cancer
Creator: Yco, Lisette Pangilinan
Date: 2019
Collection: Electronic Theses & Dissertations
Description: Autophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC....
Show moreAutophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC. First, I demonstrated that stabilized nuclear wild-type p53 through HDM2 inhibition with MK-8242 or nutlin-3a could induce autophagy in tumor cells through transactivation of several autophagy-related genes (DRAM, FOXO3A, SESN2, and MRCKα) and autophagy core genes (ATG4A and ULK1). In addition, I found that inhibiting of KRAS G12C signaling and suppressing mTORC1 activity by selective KRAS G12C inhibitor, ARS-853, could drive autophagy response in KRAS G12C NSCLC cell lines. Since autophagy could also promote survival under stress induced by several anticancer agents, I designed a combination study using newly reported selective ULK1 inhibitor, ULK-101, with ARS-853 in KRAS mutant NSCLC. Autophagy inhibition with ULK-101 dramatically enhanced the ability of selective KRAS G12C inhibitor to impair the viability of KRAS G12C NSCLC. Together, my study provided evidence that autophagy serves as a survival pathway in tumor cells and that future assessment of small molecule that target autophagy core proteins may be potential cancer therapeutic option in p53 wild-type and KRAS G12C NSCLC.
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Title: Guidelines to religious station management : a descriptive analysis of the objectives, and practices of station DYSR, Dumaguete City, Philippines
Creator: Songco, Ernesto Isip
Date: 1966
Collection: Electronic Theses & Dissertations

Title: Associations of four PROMIS self-efficacy for managing chronic conditions measures and the patient activation measure (PAM) among acute stroke survivors : an analysis of the Michigan Stroke Transitions Trial (MISTT) data
Creator: Fritz, Michele Christine
Date: 2019
Collection: Electronic Theses & Dissertations
Description: "BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self...
Show more"BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self-efficacy (SE) measures [managing medications and treatment, activities of daily living, emotions, and social interactions] and the Patient Activation Measure (PAM). METHODS: Self-reported outcomes were collected 7-days after returning home. PAM measures skill, knowledge, and confidence to manage health and healthcare, while PROMIS SE measures confidence across 4 unique domains. Independent associations of patient characteristics with each PROMIS SE and PAM were determined using a staged multivariable regression model-building approach. Finally, multivariable regression between each PROMIS SE and PAM were explored along with confounding and interaction effects. Variables significantly associated with both SE and PAM were considered as confounders and moderators. Age and education were forced into all models. RESULTS: For 180 patients mean PAM scores were 64.5 (SD: 16) and SE T-scores were near the standard mean of 50 except for SE for managing daily activities (43.5, SD: 7.5). PAM was positively correlated with each SE measure (r=0.28 to r=0.46). Only perceived emotional support and post-stroke disability were associated with both PAM and SE. Emotional support attenuated the association between all SE domains and PAM, whereas post-stroke disability only affected SE for managing daily activities. After adjusting for potential confounders, SE for managing daily activities was no longer associated with PAM. No significant interactions were found. CONCLUSIONS: During acute stroke recovery, PROMIS SE and PAM are associated. It is important to account for perceived support and disability. Longitudinal MISTT analyses will explore mediation effects to help inform causal associations between demographic, clinical, and psychosocial factors, intervention effects, and outcomes."--Page ii.
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Title: The use of fungicidal sprays to reduce mold counts in black raspberries
Creator: Young, William Justin
Date: 1955
Collection: Electronic Theses & Dissertations

Title: The relative stabilities of metal-organic complexes in recent lake sediment
Creator: Sonaike, Susanna Yetunde
Date: 1975
Collection: Electronic Theses & Dissertations

Title: The reaction of organozinc compound with carbon monoxide
Creator: Yu, Tsenwhei Helen
Date: 1970
Collection: Electronic Theses & Dissertations

Title: A study of water vapor transmission rate of blister packs by USP standard and continuous gravimetric protocol
Creator: Mehrotra, Nikhil
Date: 2010
Collection: Electronic Theses & Dissertations
Description: The water vapor transmission rate (WVTR) is essential in determining the shelf life of pharmaceutical products in the package. The WVTR of blister pack was determined by using USP 671 and the continuous gravimetric protocols. The WVTR values from the two protocols were compared and the accuracy was validated.The WVTR of the blister pack determined using the USP 671 protocol was 0.0452 mg/day/blister with a standard error of 0.0010 while the WVTR using the continuous gravimetric protocol was 0...
Show moreThe water vapor transmission rate (WVTR) is essential in determining the shelf life of pharmaceutical products in the package. The WVTR of blister pack was determined by using USP 671 and the continuous gravimetric protocols. The WVTR values from the two protocols were compared and the accuracy was validated.The WVTR of the blister pack determined using the USP 671 protocol was 0.0452 mg/day/blister with a standard error of 0.0010 while the WVTR using the continuous gravimetric protocol was 0.0652 mg/day/blister with a standard error of 0.0067. The WVTR were compared using t-statistic for unequal sample size with unequal variance and no significant difference was detected. The accuracy of the two protocols was compared through the pooled variance of the data points and it was found that the USP 671 standard protocol had a pooled variance of 4.99 x 10-4 while for the continuous gravimetric protocol it was 2.13 x 10-5. Therefore the continuous gravimetric protocol showed higher accuracy than the USP standard protocol Several recommendations have been suggested for the USP standard protocol in order to make the protocol more accurate: To determine the WVTR of the blister pack, the unsteady state should be considered and excluded from the calculation, Monitoring of the relative humidity and temperature throughout the experiment is critical, Chamber size and the time of equilibrium for the specific relative humidity needs to be outlined.
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