Search results

Title: Therapeutically targeting autophagy in non-small cell lung cancer
Creator: Yco, Lisette Pangilinan
Date: 2019
Collection: Electronic Theses & Dissertations
Description: Autophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC....
Show moreAutophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC. First, I demonstrated that stabilized nuclear wild-type p53 through HDM2 inhibition with MK-8242 or nutlin-3a could induce autophagy in tumor cells through transactivation of several autophagy-related genes (DRAM, FOXO3A, SESN2, and MRCKα) and autophagy core genes (ATG4A and ULK1). In addition, I found that inhibiting of KRAS G12C signaling and suppressing mTORC1 activity by selective KRAS G12C inhibitor, ARS-853, could drive autophagy response in KRAS G12C NSCLC cell lines. Since autophagy could also promote survival under stress induced by several anticancer agents, I designed a combination study using newly reported selective ULK1 inhibitor, ULK-101, with ARS-853 in KRAS mutant NSCLC. Autophagy inhibition with ULK-101 dramatically enhanced the ability of selective KRAS G12C inhibitor to impair the viability of KRAS G12C NSCLC. Together, my study provided evidence that autophagy serves as a survival pathway in tumor cells and that future assessment of small molecule that target autophagy core proteins may be potential cancer therapeutic option in p53 wild-type and KRAS G12C NSCLC.
Show less

Title: Guidelines to religious station management : a descriptive analysis of the objectives, and practices of station DYSR, Dumaguete City, Philippines
Creator: Songco, Ernesto Isip
Date: 1966
Collection: Electronic Theses & Dissertations

Title: Associations of four PROMIS self-efficacy for managing chronic conditions measures and the patient activation measure (PAM) among acute stroke survivors : an analysis of the Michigan Stroke Transitions Trial (MISTT) data
Creator: Fritz, Michele Christine
Date: 2019
Collection: Electronic Theses & Dissertations
Description: "BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self...
Show more"BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self-efficacy (SE) measures [managing medications and treatment, activities of daily living, emotions, and social interactions] and the Patient Activation Measure (PAM). METHODS: Self-reported outcomes were collected 7-days after returning home. PAM measures skill, knowledge, and confidence to manage health and healthcare, while PROMIS SE measures confidence across 4 unique domains. Independent associations of patient characteristics with each PROMIS SE and PAM were determined using a staged multivariable regression model-building approach. Finally, multivariable regression between each PROMIS SE and PAM were explored along with confounding and interaction effects. Variables significantly associated with both SE and PAM were considered as confounders and moderators. Age and education were forced into all models. RESULTS: For 180 patients mean PAM scores were 64.5 (SD: 16) and SE T-scores were near the standard mean of 50 except for SE for managing daily activities (43.5, SD: 7.5). PAM was positively correlated with each SE measure (r=0.28 to r=0.46). Only perceived emotional support and post-stroke disability were associated with both PAM and SE. Emotional support attenuated the association between all SE domains and PAM, whereas post-stroke disability only affected SE for managing daily activities. After adjusting for potential confounders, SE for managing daily activities was no longer associated with PAM. No significant interactions were found. CONCLUSIONS: During acute stroke recovery, PROMIS SE and PAM are associated. It is important to account for perceived support and disability. Longitudinal MISTT analyses will explore mediation effects to help inform causal associations between demographic, clinical, and psychosocial factors, intervention effects, and outcomes."--Page ii.
Show less

Title: The use of fungicidal sprays to reduce mold counts in black raspberries
Creator: Young, William Justin
Date: 1955
Collection: Electronic Theses & Dissertations

Title: The relative stabilities of metal-organic complexes in recent lake sediment
Creator: Sonaike, Susanna Yetunde
Date: 1975
Collection: Electronic Theses & Dissertations

Title: The reaction of organozinc compound with carbon monoxide
Creator: Yu, Tsenwhei Helen
Date: 1970
Collection: Electronic Theses & Dissertations

Title: A study of water vapor transmission rate of blister packs by USP standard and continuous gravimetric protocol
Creator: Mehrotra, Nikhil
Date: 2010
Collection: Electronic Theses & Dissertations
Description: The water vapor transmission rate (WVTR) is essential in determining the shelf life of pharmaceutical products in the package. The WVTR of blister pack was determined by using USP 671 and the continuous gravimetric protocols. The WVTR values from the two protocols were compared and the accuracy was validated.The WVTR of the blister pack determined using the USP 671 protocol was 0.0452 mg/day/blister with a standard error of 0.0010 while the WVTR using the continuous gravimetric protocol was 0...
Show moreThe water vapor transmission rate (WVTR) is essential in determining the shelf life of pharmaceutical products in the package. The WVTR of blister pack was determined by using USP 671 and the continuous gravimetric protocols. The WVTR values from the two protocols were compared and the accuracy was validated.The WVTR of the blister pack determined using the USP 671 protocol was 0.0452 mg/day/blister with a standard error of 0.0010 while the WVTR using the continuous gravimetric protocol was 0.0652 mg/day/blister with a standard error of 0.0067. The WVTR were compared using t-statistic for unequal sample size with unequal variance and no significant difference was detected. The accuracy of the two protocols was compared through the pooled variance of the data points and it was found that the USP 671 standard protocol had a pooled variance of 4.99 x 10-4 while for the continuous gravimetric protocol it was 2.13 x 10-5. Therefore the continuous gravimetric protocol showed higher accuracy than the USP standard protocol Several recommendations have been suggested for the USP standard protocol in order to make the protocol more accurate: To determine the WVTR of the blister pack, the unsteady state should be considered and excluded from the calculation, Monitoring of the relative humidity and temperature throughout the experiment is critical, Chamber size and the time of equilibrium for the specific relative humidity needs to be outlined.
Show less

Title: A reinforced concrete stadium dormitory design
Creator: Snow, Arthur William
Date: 1947
Collection: Electronic Theses & Dissertations

Title: A comparison of the results of teacher-direction & teacher-assistance in the presentation of American & English literature to high school classes
Creator: Tenhaaf, Mable Cornelia
Date: 1940
Collection: Electronic Theses & Dissertations

Title: The effect of continuous versus intermittent exposure to rock and roll music upon temporary threshold shift
Creator: Smitley, Ellen K.
Date: 1969
Collection: Electronic Theses & Dissertations

Title: The Red Cross Disaster Relief Advisory Committee : a study of an administrative device of a bureaucratic organization
Creator: Smucker, Melvin Joseph
Date: 1961
Collection: Electronic Theses & Dissertations

Title: The natiuretic action of DT-327
Creator: Terry, Bernard
Date: 1968
Collection: Electronic Theses & Dissertations

Title: Communication behavior in potential conflict situations : a comparison of story completions by schoolchildren of Germany, Brazil and the United States
Creator: Smith, Leticia Marcelo, 1940-
Date: 1966
Collection: Electronic Theses & Dissertations

Title: An investigation of the use of quantification in articulation testing of functional articulatory disorders
Creator: Smith, Norma J.
Date: 1965
Collection: Electronic Theses & Dissertations

Title: Current check out systems in retail food stores
Creator: Royer, Richard Bradley
Date: 1951
Collection: Electronic Theses & Dissertations

Title: Board composition in the Lansing Family Service Agency in relation to community changes (1920 through 1957)
Creator: Rozan, Dorothy C.
Date: 1958
Collection: Electronic Theses & Dissertations

Title: Curative and rainfastness characteristics of insecticides used to control Spotted Wing Drosophila (Matsumura) in tart cherry productions
Creator: Andika, Ignatius Putra
Date: 2018
Collection: Electronic Theses & Dissertations
Description: Spotted wing drosophila (Drosophila suzukii Matsumura) (SWD) is an invasive pest originated from East Asia, which has caused devastating damaged to soft-skinned fruit productions globally and an increase of growers’ reliance on insecticide to meet market standards. However, the intensive use of insecticides raises community concerns regarding environmental health, human health, and the risk of SWD population to grow resistances. Therefore, exploring other activity modes of insecticides...
Show moreSpotted wing drosophila (Drosophila suzukii Matsumura) (SWD) is an invasive pest originated from East Asia, which has caused devastating damaged to soft-skinned fruit productions globally and an increase of growers’ reliance on insecticide to meet market standards. However, the intensive use of insecticides raises community concerns regarding environmental health, human health, and the risk of SWD population to grow resistances. Therefore, exploring other activity modes of insecticides registered against SWD besides adulticide action may provide information to refine existing insecticide programs. The data from these experiments provide insight of the curative and rainfastness of insecticides registered against SWD in tart cherry productions. The residue data in these experiments compliment the biological data and provide better understanding on how these insecticides work against SWD.
Show less