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- Title
- Glucose flux in monocytes of periparturient dairy cows
- Creator
- O'Boyle, Nial
- Date
- 2011
- Collection
- Electronic Theses & Dissertations
- Description
-
The incidence of periparturient disease in dairy cows continues to remain unacceptably high. This persists despite an industry research focus into both managemental and nutritional intervention over the last few decades. The intense lipomobilization and glycemic dysregulation during early lactation have drawn parallels with human metabolic conditions and states of immune dysfunction. The pronounced glucose demand by the mammary gland for milk synthesis leads to substantial metabolic change....
Show moreThe incidence of periparturient disease in dairy cows continues to remain unacceptably high. This persists despite an industry research focus into both managemental and nutritional intervention over the last few decades. The intense lipomobilization and glycemic dysregulation during early lactation have drawn parallels with human metabolic conditions and states of immune dysfunction. The pronounced glucose demand by the mammary gland for milk synthesis leads to substantial metabolic change. Little is known how glucose uptake in key immune cells such as the monocyte may be affected. The objective of this study was to identify and examine the expression of glucose transporters (GLUTs) in bovine monocytes and how they may alter as a consequence of lactogenesis and upon stimulation with endotoxin. Sampling points were refined to select 10 cows at 28-35d before expected calving and at 5 ± 2d after calving. Monocytes were isolated from total peripheral blood mononuclear cells, GLUT isoforms 1,3 and 4 were assessed for mRNA and protein expression following endotoxin stimulation. GLUT isoforms were found to change expression as a consequence of lactogenesis and endotoxin stimulation. This finding warrants further investigation into energy utilization of immune cells during the periparturient period and how it may contribute to immune dysfunction.
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- Title
- Software tool for performing the calibration of the AT-TPC electronics channels
- Creator
- Ndayisabye, Felix
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
-
"The Active Target Time Projection Chamber (AT-TPC), developed at the National Superconducting CyclotronLaboratory (NSCL) at Michigan State University, is a gas-based system that serves a dual role of a target and detector medium for nuclear physics experiments. Active target devices have gained much attention within the past dedicate due to their high resolution and efficiency to study reactions with very exotic nuclei. With the use of incident beam energy ranging from low (1-10 MeV/u) to...
Show more"The Active Target Time Projection Chamber (AT-TPC), developed at the National Superconducting CyclotronLaboratory (NSCL) at Michigan State University, is a gas-based system that serves a dual role of a target and detector medium for nuclear physics experiments. Active target devices have gained much attention within the past dedicate due to their high resolution and efficiency to study reactions with very exotic nuclei. With the use of incident beam energy ranging from low (1-10 MeV/u) to medium (10-100 MeV/u) to extract the physical properties of nuclei far from stability, the AT-TPC is contributing significantly to experimental nuclear science, thanks to its high luminosity working capability without loss of resolution and low-energy detection thresholds that enable experiments with beam intensities as low as 102 pps. Because of its unique features, a dedicated python based data analysis tool was developed to extract information from this detector. This software tool allows to calibrate the electronic baselines, amplitudes and times of the signals recorded by each of the AT-TPC pads relative to each other. The statistical analysis of the aforementioned calibrated parameters shows the coefficient of the fluctuations of the order of 9.1 % and 8.8 % for the baselines , 3.43 % and 4.8 % for the amplitudes and 45 ns and 34 ns for the time from the big and small pads respectively from all 24 events taken during the pulse run."--Page ii.
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- Title
- A nonconventional morphometric technique for measuring ontogenetic shape changes in two species of centrarchid fishes
- Creator
- Zablotny, James E. (James Edward)
- Date
- 1989
- Collection
- Electronic Theses & Dissertations
- Title
- Analysis of Daimler-Chrysler/ European radiated emissions testing set-up for modules
- Creator
- Coleman, Christopher Mark
- Date
- 1999
- Collection
- Electronic Theses & Dissertations
- Title
- Loss of compression strength in corrugated boxes during overnight shipments in UPS
- Creator
- Pratheepthinthong, Supoj
- Date
- 1999
- Collection
- Electronic Theses & Dissertations
- Title
- The static measurement as a predictor to the dynamic axis of rotation of the human foot
- Creator
- Bratta, Brian A.
- Date
- 2004
- Collection
- Electronic Theses & Dissertations
- Title
- A rheological model of apple flesh failure during the Magness-Taylor puncture test
- Creator
- Jeong, Sanghyup
- Date
- 1997
- Collection
- Electronic Theses & Dissertations
- Title
- Techniques for measuring in-situ oil drop distribution and concentration
- Creator
- Rushlow, Thomas Mark
- Date
- 1988
- Collection
- Electronic Theses & Dissertations