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- Title
- Retention and learning in normal and brain-lesioned rhesus monkeys after a six-year interval
- Creator
- Marshall, Bruce Ray
- Date
- 1971
- Collection
- Electronic Theses & Dissertations
- Title
- Development of a spice formulation for pure culture fermented cucumber pickles
- Creator
- Marshall, Cecelia Kuhnley
- Date
- 1971
- Collection
- Electronic Theses & Dissertations
- Title
- Timelessness and process-reactive schizophrenia
- Creator
- Brand, Don J.
- Date
- 1975
- Collection
- Electronic Theses & Dissertations
- Title
- Effects of an ion exchange resin artificial kidney in dogs
- Creator
- Richardson, John H.
- Date
- 1960
- Collection
- Electronic Theses & Dissertations
- Title
- Silage removal from the horizontal silo
- Creator
- Rich, Nathan Harold
- Date
- 1953
- Collection
- Electronic Theses & Dissertations
- Title
- A study of the relative length of the forcing period required by the new lily Lilium longiflorum variety downingi, as compared to the standard Easter lily varieties L. longiflorum varieties giganteum and erabu
- Creator
- Roberts, Evan P.
- Date
- 1941
- Collection
- Electronic Theses & Dissertations
- Title
- A follow-up study of former students enrolled in agriculture in Flathead county high school, Kalispell, Montana during the period 1913 to 1949
- Creator
- Robinson, Henry Edward
- Date
- 1952
- Collection
- Electronic Theses & Dissertations
- Title
- Variation in feed efficiency and carcass characteristics of individually fed swine
- Creator
- Vorkapich, Mike
- Date
- 1955
- Collection
- Electronic Theses & Dissertations
- Title
- The effect of growth-restriction on voluntary physical activity engagement in mice
- Creator
- Leszczynski, Eric
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
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INTRODUCTION. Current evidence suggests that early life growth restriction reduces physical activity engagement. Therefore, the purpose of this investigation was to examine the effects of early life growth-restriction on levels of wheel running in mice, and determine if known biological mechanisms regulate physical activity engagement. METHODS. Using a cross-fostering, protein-restricted nutritive model, mice were growth-restricted during either gestation (GUN; N = 3 litters) or postnatal...
Show moreINTRODUCTION. Current evidence suggests that early life growth restriction reduces physical activity engagement. Therefore, the purpose of this investigation was to examine the effects of early life growth-restriction on levels of wheel running in mice, and determine if known biological mechanisms regulate physical activity engagement. METHODS. Using a cross-fostering, protein-restricted nutritive model, mice were growth-restricted during either gestation (GUN; N = 3 litters) or postnatal life (PUN; N = 3 litters), along with a well fed control group (CON; N = 3 litters). At 21 days of age, all mice pups were weaned and fed a non-restrictive healthy diet for the remainder of the study. At 45 days of age mice were individually housed in cages with free moving running wheels to assess physical activity engagement. At day 70, mice were euthanized, and the nucleus accumbens was analyzed for dopamine receptor 1 expression. Skeletal muscle fiber type and cross-sectional area of the soleus, extensor digitorom longus, and diaphragm were analyzed by immunohistochemistry. The soleus from the other hind leg was evaluated for calsequestrin 1 and annexin A6 expression. RESULTS. The PUN female mice had a reduction (P = 0.0221) in wheel revolutions per day as compared to the GUN and CON females. PUN female mice also expressed significantly higher Drd1(P = 0.0247) and Casq1 (P = 0.0398) compared to the other groups. CONCLUSION. Growth-restriction during lactation reduced physical activity in female mice by reducing the central drive to be active and displayed a more fatigable skeletal muscle phenotype.
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- Title
- Techniques and results of applying thiourea to synthetic and grass silage media for the control of Stomoxys calcitrans Linnaeus
- Creator
- Weinburgh, Harry B.
- Date
- 1956
- Collection
- Electronic Theses & Dissertations
- Title
- A survey study of the metazoan fauna of the psammolittoral zone of Mud Lake, Barry County, Michigan
- Creator
- Weber, Peter Gotthilf
- Date
- 1963
- Collection
- Electronic Theses & Dissertations
- Title
- River valley lands in Southwestern Ontario
- Creator
- Weber, Edward J.
- Date
- 1966
- Collection
- Electronic Theses & Dissertations
- Title
- A study of the development and awareness of the need for creative uses of leisure time of high school students in a working class community
- Creator
- Welch, Gordon R.
- Date
- 1967
- Collection
- Electronic Theses & Dissertations
- Title
- The initial phase of pathogenesis in Victoria blight of oats
- Creator
- Yoder, Olen C.
- Date
- 1968
- Collection
- Electronic Theses & Dissertations
- Title
- Friction equivalents of take-offs in rectangular ducts
- Creator
- Yohn, James Harold
- Date
- 1950
- Collection
- Electronic Theses & Dissertations
- Title
- The effect of chain extender on the molecular weight and hydrolytic degradation of poly(lactic acid)
- Creator
- Limsukon, Wanwarang
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
-
"The effect of chain extender (Cex) on the molecular weight properties and hydrolytic degradation of modified PLA films (PLA--Cex) was determined and compared with PLA without Cex (PLA--Con). Effects of the Cex content and the residence time on the molecular weight were reviewed using melt blending and compression molding. A response surface methodology was applied to design the experiments and estimate the optimal conditions for obtaining the maximum weight average and number average...
Show more"The effect of chain extender (Cex) on the molecular weight properties and hydrolytic degradation of modified PLA films (PLA--Cex) was determined and compared with PLA without Cex (PLA--Con). Effects of the Cex content and the residence time on the molecular weight were reviewed using melt blending and compression molding. A response surface methodology was applied to design the experiments and estimate the optimal conditions for obtaining the maximum weight average and number average molecular weight achieved at 1.5 wt% Cex and residence time of 17 minutes. The hydrolytic degradation experiments were run in water from 40 to 95 °C and in 50% ethanol from 40 to 85 °C. The rate of hydrolytic degradation of PLA--Cex film was estimated using mathematical models, and it was considerably lower than that of PLA--Con in all conditions. The activation energy for hydrolysis above Tg was determined using the Arrhenius equation, showing no significant difference between PLA--Cex and PLA--Con. The Vogel-Tammann-Fulcher (VTF) and the Williams-Landel-Ferry (WLF) models were used for studying the hydrolytic degradation of polymers over a broad range of temperature crossing Tg. A master curve was constructed using the time-temperature superposition principle. The experimental data at 85 °C were used to predict the degradation behavior at 40 °C. It was found that PLA--Cex would take approximately 72 percent more time than PLA--Con to degrade to soluble oligomer chains."--Page ii.
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- Title
- Therapeutically targeting autophagy in non-small cell lung cancer
- Creator
- Yco, Lisette Pangilinan
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
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Autophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC....
Show moreAutophagy is a conserved catabolic pathway which sequesters intracellular components in lysosomes to recycle macromolecules for cell maintenance. The role of autophagy in tumor cells is dynamic and depends on many factors including tumor types, tumor stages, and activity of several tumor suppressors and oncogenes. In this thesis, I wanted to improve our understanding of the unique relationship of autophagy with tumor suppressor p53 and oncogenic KRAS in cancer cells, particularly in NSCLC. First, I demonstrated that stabilized nuclear wild-type p53 through HDM2 inhibition with MK-8242 or nutlin-3a could induce autophagy in tumor cells through transactivation of several autophagy-related genes (DRAM, FOXO3A, SESN2, and MRCKα) and autophagy core genes (ATG4A and ULK1). In addition, I found that inhibiting of KRAS G12C signaling and suppressing mTORC1 activity by selective KRAS G12C inhibitor, ARS-853, could drive autophagy response in KRAS G12C NSCLC cell lines. Since autophagy could also promote survival under stress induced by several anticancer agents, I designed a combination study using newly reported selective ULK1 inhibitor, ULK-101, with ARS-853 in KRAS mutant NSCLC. Autophagy inhibition with ULK-101 dramatically enhanced the ability of selective KRAS G12C inhibitor to impair the viability of KRAS G12C NSCLC. Together, my study provided evidence that autophagy serves as a survival pathway in tumor cells and that future assessment of small molecule that target autophagy core proteins may be potential cancer therapeutic option in p53 wild-type and KRAS G12C NSCLC.
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- Title
- Guidelines to religious station management : a descriptive analysis of the objectives, and practices of station DYSR, Dumaguete City, Philippines
- Creator
- Songco, Ernesto Isip
- Date
- 1966
- Collection
- Electronic Theses & Dissertations
- Title
- Associations of four PROMIS self-efficacy for managing chronic conditions measures and the patient activation measure (PAM) among acute stroke survivors : an analysis of the Michigan Stroke Transitions Trial (MISTT) data
- Creator
- Fritz, Michele Christine
- Date
- 2019
- Collection
- Electronic Theses & Dissertations
- Description
-
"BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self...
Show more"BACKGROUND: Successful stroke transitions rely on effective self-management abilities to address stroke deficits and to prevent recurrent stroke. Patient activation and self-efficacy (confidence) are two behavioral constructs that influence successful self-management and are associated with healthier lifestyles and better health outcomes. OBJECTIVE: This cross-sectional, secondary analysis of the Michigan Stroke Transitions Trial aimed to determine the associations between 4 PROMIS self-efficacy (SE) measures [managing medications and treatment, activities of daily living, emotions, and social interactions] and the Patient Activation Measure (PAM). METHODS: Self-reported outcomes were collected 7-days after returning home. PAM measures skill, knowledge, and confidence to manage health and healthcare, while PROMIS SE measures confidence across 4 unique domains. Independent associations of patient characteristics with each PROMIS SE and PAM were determined using a staged multivariable regression model-building approach. Finally, multivariable regression between each PROMIS SE and PAM were explored along with confounding and interaction effects. Variables significantly associated with both SE and PAM were considered as confounders and moderators. Age and education were forced into all models. RESULTS: For 180 patients mean PAM scores were 64.5 (SD: 16) and SE T-scores were near the standard mean of 50 except for SE for managing daily activities (43.5, SD: 7.5). PAM was positively correlated with each SE measure (r=0.28 to r=0.46). Only perceived emotional support and post-stroke disability were associated with both PAM and SE. Emotional support attenuated the association between all SE domains and PAM, whereas post-stroke disability only affected SE for managing daily activities. After adjusting for potential confounders, SE for managing daily activities was no longer associated with PAM. No significant interactions were found. CONCLUSIONS: During acute stroke recovery, PROMIS SE and PAM are associated. It is important to account for perceived support and disability. Longitudinal MISTT analyses will explore mediation effects to help inform causal associations between demographic, clinical, and psychosocial factors, intervention effects, and outcomes."--Page ii.
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- Title
- The use of fungicidal sprays to reduce mold counts in black raspberries
- Creator
- Young, William Justin
- Date
- 1955
- Collection
- Electronic Theses & Dissertations