Search results

Title: ASSESSMENT OF CROSS-FREQUENCY PHASE-AMPLITUDE COUPLING IN NEURONAL OSCILLATIONS
Creator: Munia, Tamanna Tabassum Khan
Date: 2021
Collection: Electronic Theses & Dissertations
Description: Oscillatory activity in the brain has been associated with a wide variety of cognitive processes including decision making, feedback processing, and working memory control. The high temporal resolution provided by electroencephalography (EEG) enables the study of variation of oscillatory power and coupling across time. Various forms of neural synchrony across frequency bands have been suggested as the mechanism underlying neural binding. Recently, a considerable amount of work has focused on...
Show moreOscillatory activity in the brain has been associated with a wide variety of cognitive processes including decision making, feedback processing, and working memory control. The high temporal resolution provided by electroencephalography (EEG) enables the study of variation of oscillatory power and coupling across time. Various forms of neural synchrony across frequency bands have been suggested as the mechanism underlying neural binding. Recently, a considerable amount of work has focused on phase-amplitude coupling (PAC)– a form of cross-frequency coupling where the amplitude of a high-frequency signal is modulated by the phase of low-frequency oscillations.The existing methods for assessing PAC have certain limitations which can influence the final PAC estimates and the subsequent neuroscientific findings. These limitations include low frequency resolution, narrowband assumption, and inherent requirement of bandpass filtering. These methods are also limited to quantifying univariate PAC and cannot capture inter-areal cross frequency coupling between different brain regions. Given the availability of multi-channel recordings, a multivariate analysis of phase-amplitude coupling is needed to accurately quantify the coupling across multiple frequencies and brain regions. Moreover, the existing PAC measures are usually stationary in nature, focusing on phase-amplitude modulations within a particular time window or over arbitrary sliding short time windows. Therefore, there is a need for computationally efficient measures that can quantify PAC with a high-frequency resolution, track the variation of PAC with time, both in bivariate and multivariate settings and provide a better insight into the spatially distributed dynamic brain networks across different frequency bands.In this thesis, we introduce a PAC computation technique that aims to overcome some of these drawbacks and extend it to multi-channel settings for quantifying dynamic cross-frequency coupling in the brain. The main contributions of the thesis are threefold. First, we present a novel time frequency based PAC (t-f PAC) measure based on a high-resolution complex time-frequency distribution, known as the Reduced Interference Distribution (RID)-Rihaczek. This t-f PAC measure overcomes the drawbacks associated with filtering by extracting instantaneous phase and amplitude components directly from the t-f distribution and thus provides high resolution PAC estimates. Following the introduction of a complex time-frequency-based high resolution PAC measure, we extend this measure to multi-channel settings to quantify the inter-areal PAC across multiple frequency bands and brain regions. We propose a tensor-based representation of multi-channel PAC based on Higher Order Robust PCA (HoRPCA). The proposed method can identify the significantly coupled brain regions along with the frequency bands that are involved in the observed couplings while accurately discarding the non-significant or spurious couplings. Finally, we introduce a matching pursuit based dynamic PAC (MP-dPAC) measure that allows us to compute PAC from time and frequency localized atoms that best describe the signal and thus capture the temporal variation of PAC using a data-driven approach. We evaluate the performance of the proposed methods on both synthesized and real EEG data collected during a cognitive control-related error processing study. Based on our results, we posit that the proposed multivariate and dynamic PAC measures provide a better insight into understanding the spatial, spectral, and temporal dynamics of cross-frequency phase-amplitude coupling in the brain.
Show less

Title: Signal Processing Based Distortion Mitigation in Interferometric Radar Angular Velocity Estimation
Creator: Klinefelter, Eric
Date: 2021
Collection: Electronic Theses & Dissertations
Description: Interferometric angular velocity estimation is a relatively recent radar technique which uses a pair of widely spaced antenna elements and a correlation receiver to directly measure the angular velocity of a target. Traditional radar systems measure range, radial velocity (Doppler), and angle, while angular velocity is typically derived as the time-rate change of the angle measurements. The noise associated with the derived angular velocity estimate is statistically correlated with the angle...
Show moreInterferometric angular velocity estimation is a relatively recent radar technique which uses a pair of widely spaced antenna elements and a correlation receiver to directly measure the angular velocity of a target. Traditional radar systems measure range, radial velocity (Doppler), and angle, while angular velocity is typically derived as the time-rate change of the angle measurements. The noise associated with the derived angular velocity estimate is statistically correlated with the angle measurements, and thus provides no additional information to traditional state space trackers. Interferometric angular velocity estimation, on the other hand, provides an independent measurement, thus forming a basis in R2 for both position and velocity.While promising results have been presented for single target interferometric angular velocity estimation, there is a known issue which arises when multiple targets are present. The ideal interferometric response with multiple targets would contain only the mixing product between like targets across the antenna responses, yet instead, the mixing product between all targets is generated, resulting in unwanted `cross-terms' or intermodulation distortion. To date, various hardware based methods have been presented, which are effective, though they tend to require an increased number of antenna elements, a larger physical system baseline, or signals with wide bandwidths. Presented here are novel methods for signal processing based interferometric angular velocity estimation distortion mitigation, which can be performed with only a single antenna pair and traditional continuous-wave or frequency-modulated continuous wave signals.In this work, two classes of distortion mitigation methods are described: model-based and response decomposition. Model-based methods use a learned or analytic model with traditional non-linear optimization techniques to arrive at angular velocity estimates based on the complete interferometric signal response. Response decomposition methods, on the other hand, aim to decompose the individual antenna responses into separate responses pertaining to each target, then associate like targets between antenna responses. By performing the correlation in this manner, the cross-terms, which typically corrupt the interferometric response, are mitigated. It was found that due to the quadratic scaling of distortion terms, model-based methods become exceedingly difficult as the number of targets grows large. Thus, the method of response decomposition is selected and results on measured radar signals are presented. For this, a custom single-board millimeter-wave interferometric radar was developed, and angular velocity measurements were performed in an enclosed environment consisting of two robotic targets. A set of experiments was designed to highlight easy, medium, and difficult cases for the response decomposition algorithm, and results are presented herein.
Show less

Title: LIDAR AND CAMERA CALIBRATION USING A MOUNTED SPHERE
Creator: Li, Jiajia
Date: 2020
Collection: Electronic Theses & Dissertations
Description: Extrinsic calibration between lidar and camera sensors is needed for multi-modal sensor data fusion. However, obtaining precise extrinsic calibration can be tedious, computationally expensive, or involve elaborate apparatus. This thesis proposes a simple, fast, and robust method performing extrinsic calibration between a camera and lidar. The only required calibration target is a hand-held colored sphere mounted on a whiteboard. The convolutional neural networks are developed to automatically...
Show moreExtrinsic calibration between lidar and camera sensors is needed for multi-modal sensor data fusion. However, obtaining precise extrinsic calibration can be tedious, computationally expensive, or involve elaborate apparatus. This thesis proposes a simple, fast, and robust method performing extrinsic calibration between a camera and lidar. The only required calibration target is a hand-held colored sphere mounted on a whiteboard. The convolutional neural networks are developed to automatically localize the sphere relative to the camera and the lidar. Then using the localization covariance models, the relative pose between the camera and lidar is derived. To evaluate the accuracy of our method, we record image and lidar data of a sphere at a set of known grid positions by using two rails mounted on a wall. The accurate calibration results are demonstrated by projecting the grid centers into the camera image plane and finding the error between these points and the hand-labeled sphere centers.
Show less

Title: Harnessing low-pass filter defects for improving wireless link performance : measurements and applications
Creator: Renani, Alireza Ameli
Date: 2018
Collection: Electronic Theses & Dissertations
Description: "The design trade-offs of transceiver hardware are crucial to the performance of wireless systems. The effect of such trade-offs on individual analog and digital components are vigorously studied, but their systemic impacts beyond component-level remain largely unexplored. In this dissertation, we present an in-depth study to characterize the surprisingly notable systemic impacts of low-pass filter design, which is a small yet indispensable component used for shaping spectrum and rejecting...
Show more"The design trade-offs of transceiver hardware are crucial to the performance of wireless systems. The effect of such trade-offs on individual analog and digital components are vigorously studied, but their systemic impacts beyond component-level remain largely unexplored. In this dissertation, we present an in-depth study to characterize the surprisingly notable systemic impacts of low-pass filter design, which is a small yet indispensable component used for shaping spectrum and rejecting interference. Using a bottom-up approach, we examine how signal-level distortions caused by the trade-offs of low-pass filter design propagate to the upper-layers of wireless communication, reshaping bit error patterns and degrading link performance of today's 802.11 systems. Moreover, we propose a novel unequal error protection algorithm that harnesses low-pass filter defects for improving wireless LAN throughput, particularly to be used in forward error correction, channel coding, and applications such as video streaming. Lastly, we conduct experiments to evaluate the unequal error protection algorithm in video streaming, and we present substantial enhancements of video quality in mobile environments."--Page ii.
Show less

Title: Assessment of functional connectivity in the human brain : multivariate and graph signal processing methods
Creator: Villafañe-Delgado, Marisel
Date: 2017
Collection: Electronic Theses & Dissertations
Description: "Advances in neurophysiological recording have provided a noninvasive way of inferring cognitive processes. Recent studies have shown that cognition relies on the functional integration or connectivity of segregated specialized regions in the brain. Functional connectivity quantifies the statistical relationships among different regions in the brain. However, current functional connectivity measures have certain limitations in the quantification of global integration and characterization of...
Show more"Advances in neurophysiological recording have provided a noninvasive way of inferring cognitive processes. Recent studies have shown that cognition relies on the functional integration or connectivity of segregated specialized regions in the brain. Functional connectivity quantifies the statistical relationships among different regions in the brain. However, current functional connectivity measures have certain limitations in the quantification of global integration and characterization of network structure. These limitations include the bivariate nature of most functional connectivity measures, the computational complexity of multivariate measures, and graph theoretic measures that are not robust to network size and degree distribution. Therefore, there is a need of computationally efficient and novel measures that can quantify the functional integration across brain regions and characterize the structure of these networks. This thesis makes contributions in three different areas for the assessment of multivariate functional connectivity. First, we present a novel multivariate phase synchrony measure for quantifying the common functional connectivity within different brain regions. This measure overcomes the drawbacks of bivariate functional connectivity measures and provides insights into the mechanisms of cognitive control not accountable by bivariate measures. Following the assessment of functional connectivity from a graph theoretic perspective, we propose a graph to signal transformation for both binary and weighted networks. This provides the means for characterizing the network structure and quantifying information in the graph by overcoming some drawbacks of traditional graph based measures. Finally, we introduce a new approach to studying dynamic functional connectivity networks through signals defined over networks. In this area, we define a dynamic graph Fourier transform in which a common subspace is found from the networks over time based on the tensor decomposition of the graph Laplacian over time."--Pages ii-iii.
Show less

Title: Smartphone-based sensing systems for data-intensive applications
Creator: Moazzami, Mohammad-Mahdi
Date: 2017
Collection: Electronic Theses & Dissertations
Description: "Supported by advanced sensing capabilities, increasing computational resources and the advances in Artificial Intelligence, smartphones have become our virtual companions in our daily life. An average modern smartphone is capable of handling a wide range of tasks including navigation, advanced image processing, speech processing, cross app data processing and etc. The key facet that is common in all of these applications is the data intensive computation. In this dissertation we have taken...
Show more"Supported by advanced sensing capabilities, increasing computational resources and the advances in Artificial Intelligence, smartphones have become our virtual companions in our daily life. An average modern smartphone is capable of handling a wide range of tasks including navigation, advanced image processing, speech processing, cross app data processing and etc. The key facet that is common in all of these applications is the data intensive computation. In this dissertation we have taken steps towards the realization of the vision that makes the smartphone truly a platform for data intensive computations by proposing frameworks, applications and algorithmic solutions. We followed a data-driven approach to the system design. To this end, several challenges must be addressed before smartphones can be used as a system platform for data-intensive applications. The major challenge addressed in this dissertation include high power consumption, high computation cost in advance machine learning algorithms, lack of real-time functionalities, lack of embedded programming support, heterogeneity in the apps, communication interfaces and lack of customized data processing libraries. The contribution of this dissertation can be summarized as follows. We present the design, implementation and evaluation of the ORBIT framework, which represents the first system that combines the design requirements of a machine learning system and sensing system together at the same time. We ported for the first time off-the-shelf machine learning algorithms for real-time sensor data processing to smartphone devices. We highlighted how machine learning on smartphones comes with severe costs that need to be mitigated in order to make smartphones capable of real-time data-intensive processing. From application perspective we present SPOT. SPOT aims to address some of the challenges discovered in mobile-based smart-home systems. These challenges prevent us from achieving the promises of smart-homes due to heterogeneity in different aspects of smart devices and the underlining systems. We face the following major heterogeneities in building smart-homes:: (i) Diverse appliance control apps (ii) Communication interface, (iii) Programming abstraction. SPOT makes the heterogeneous characteristics of smart appliances transparent, and by that it minimizes the burden of home automation application developers and the efforts of users who would otherwise have to deal with appliance-specific apps and control interfaces. From algorithmic perspective we introduce two systems in the smartphone-based deep learning area: Deep-Crowd-Label and Deep-Partition. Deep neural models are both computationally and memory intensive, making them difficult to deploy on mobile applications with limited hardware resources. On the other hand, they are the most advanced machine learning algorithms suitable for real-time sensing applications used in the wild. Deep-Partition is an optimization-based partitioning meta-algorithm featuring a tiered architecture for smartphone and the back-end cloud. Deep-Partition provides a profile-based model partitioning allowing it to intelligently execute the Deep Learning algorithms among the tiers to minimize the smartphone power consumption by minimizing the deep models feed-forward latency. Deep-Crowd-Label is prototyped for semantically labeling user's location. It is a crowd-assisted algorithm that uses crowd-sourcing in both training and inference time. It builds deep convolutional neural models using crowd-sensed images to detect the context (label) of indoor locations. It features domain adaptation and model extension via transfer learning to efficiently build deep models for image labeling. The work presented in this dissertation covers three major facets of data-driven and compute-intensive smartphone-based systems: platforms, applications and algorithms; and helps to spurs new areas of research and opens up new directions in mobile computing research."--Pages ii-iii.
Show less

Title: Higher-order data reduction through clustering, subspace analysis and compression for applications in functional connectivity brain networks
Creator: Ozdemir, Alp
Date: 2017
Collection: Electronic Theses & Dissertations
Description: "With the recent advances in information technology, collection and storage of higher-order datasets such as multidimensional data across multiple modalities or variables have become much easier and cheaper than ever before. Tensors, also known as multiway arrays, provide natural representations for higher-order datasets and provide a way to analyze them by preserving the multilinear relations in these large datasets. These higher-order datasets usually contain large amount of redundant...
Show more"With the recent advances in information technology, collection and storage of higher-order datasets such as multidimensional data across multiple modalities or variables have become much easier and cheaper than ever before. Tensors, also known as multiway arrays, provide natural representations for higher-order datasets and provide a way to analyze them by preserving the multilinear relations in these large datasets. These higher-order datasets usually contain large amount of redundant information and summarizing them in a succinct manner is essential for better inference. However, existing data reduction approaches are limited to vector-type data and cannot be applied directly to tensors without vectorizing. Developing more advanced approaches to analyze tensors effectively without corrupting their intrinsic structure is an important challenge facing Big Data applications. This thesis addresses the issue of data reduction for tensors with a particular focus on providing a better understanding of dynamic functional connectivity networks (dFCNs) of the brain. Functional connectivity describes the relationship between spatially separated neuronal groups and analysis of dFCNs plays a key role for interpreting complex brain dynamics in different cognitive and emotional processes. Recently, graph theoretic methods have been used to characterize the brain functionality where bivariate relationships between neuronal populations are represented as graphs or networks. In this thesis, the changes in these networks across time and subjects will be studied through tensor representations. In Chapter 2, we address a multi-graph clustering problem which can be thought as a tensor partitioning problem. We introduce a hierarchical consensus spectral clustering approach to identify the community structure underlying the functional connectivity brain networks across subjects. New information-theoretic criteria are introduced for selecting the optimal community structure. Effectiveness of the proposed algorithms are evaluated through a set of simulations comparing with the existing methods as well as on FCNs across subjects. In Chapter 3, we address the online tensor data reduction problem through a subspace tracking perspective. We introduce a robust low-rank+sparse structure learning algorithm for tensors to separate the low-rank community structure of connectivity networks from sparse outliers. The proposed framework is used to both identify change points, where the low-rank community structure changes significantly, and summarize this community structure within each time interval. Finally, in Chapter 4, we introduce a new multi-scale tensor decomposition technique to efficiently encode nonlinearities due to rotation or translation in tensor type data. In particular, we develop a multi-scale higher-order singular value decomposition (MS-HoSVD) approach where a given tensor is first permuted and then partitioned into several sub-tensors each of which can be represented as a low-rank tensor increasing the efficiency of the representation. We derive a theoretical error bound for the proposed approach as well as provide analysis of memory cost and computational complexity. Performance of the proposed approach is evaluated on both data reduction and classification of various higher-order datasets."--Pages ii-iii.
Show less

Title: Convolutional neural networks for automated cell detection in magnetic resonance imaging data
Creator: Afridi, Muhammad Jamal
Date: 2017
Collection: Electronic Theses & Dissertations
Description: Cell-based therapy (CBT) is emerging as a promising solution for a large number of serious health issues such as brain injuries and cancer. Recent advances in CBT, has heightened interest in the non-invasive monitoring of transplanted cells in in vivo MRI (Magnetic Resonance Imaging) data. These cells appear as dark spots in MRI scans. However, to date, these spots are manually labeled by experts, which is an extremely tedious and a time consuming process. This limits the ability to conduct...
Show moreCell-based therapy (CBT) is emerging as a promising solution for a large number of serious health issues such as brain injuries and cancer. Recent advances in CBT, has heightened interest in the non-invasive monitoring of transplanted cells in in vivo MRI (Magnetic Resonance Imaging) data. These cells appear as dark spots in MRI scans. However, to date, these spots are manually labeled by experts, which is an extremely tedious and a time consuming process. This limits the ability to conduct large scale spot analysis that is necessary for the long term success of CBT. To address this gap, we develop methods to automate the spot detection task. In this regard we (a) assemble an annotated MRI database for spot detection in MRI; (b) present a superpixel based strategy to extract regions of interest from MRI; (c) design a convolutional neural network (CNN) architecture for automatically characterizing and classifying spots in MRI; (d) propose a transfer learning approach to circumvent the issue of limited training data, and (e) propose a new CNN framework that exploits labeling behavior of the expert in the learning process. Extensive experiments convey the benefits of the proposed methods.
Show less

Title: Unconstrained 3D face reconstruction from photo collections
Creator: Roth, Joseph (Software engineer)
Date: 2016
Collection: Electronic Theses & Dissertations
Description: This thesis presents a novel approach for 3D face reconstruction from unconstrained photo collections. An unconstrained photo collection is a set of face images captured under an unknown and diverse variation of poses, expressions, and illuminations. The output of the proposed algorithm is a true 3D face surface model represented as a watertight triangulated surface with albedo data colloquially referred to as texture information. Reconstructing a 3D understanding of a face based on 2D input...
Show moreThis thesis presents a novel approach for 3D face reconstruction from unconstrained photo collections. An unconstrained photo collection is a set of face images captured under an unknown and diverse variation of poses, expressions, and illuminations. The output of the proposed algorithm is a true 3D face surface model represented as a watertight triangulated surface with albedo data colloquially referred to as texture information. Reconstructing a 3D understanding of a face based on 2D input is a long-standing computer vision problem. Traditional photometric stereo-based reconstruction techniques work on aligned 2D images and produce a 2.5D depth map reconstruction. We extend face reconstruction to work with a true 3D model, allowing us to enjoy the benefits of using images from all poses, up to and including profiles. To use a 3D model, we propose a novel normal field-based Laplace editing technique which allows us to deform a triangulated mesh to match the observed surface normals. Unlike prior work that require large photo collections, we formulate an approach to adapt to photo collections with few images of potentially poor quality. We achieve this through incorporating prior knowledge about face shape by fitting a 3D Morphable Model to form a personalized template before using a novel analysis-by-synthesis photometric stereo formulation to complete the fine face details. A structural similarity-based quality measure allows evaluation in the absence of ground truth 3D scans. Superior large-scale experimental results are reported on Internet, synthetic, and personal photo collections.
Show less

Title: Efficient and secure system design in wireless communications
Creator: Song, Tianlong
Date: 2016
Collection: Electronic Theses & Dissertations
Description: Efficient and secure information transmission lies in the core part of wireless system design and networking. Comparing with its wired counterpart, in wireless communications, the total available spectrum has to be shared by different services. Moreover, wireless transmission is more vulnerable to unauthorized detection, eavesdropping and hostile jamming due to the lack of a protective physical boundary.Today, the two most representative highly efficient communication systems are CDMA (used...
Show moreEfficient and secure information transmission lies in the core part of wireless system design and networking. Comparing with its wired counterpart, in wireless communications, the total available spectrum has to be shared by different services. Moreover, wireless transmission is more vulnerable to unauthorized detection, eavesdropping and hostile jamming due to the lack of a protective physical boundary.Today, the two most representative highly efficient communication systems are CDMA (used in 3G) and OFDM (used in 4G), and OFDM is regarded as the most efficient system. This dissertation will focus on two topics: (1) Explore more spectrally efficient system design based on the 4G OFDM scheme; (2) Investigate robust wireless system design and conduct capacity analysis under different jamming scenarios. The main results are outlined as follows.First, we develop two spectrally efficient OFDM-based multi-carrier transmission schemes: one with message-driven idle subcarriers (MC-MDIS), and the other with message-driven strengthened subcarriers (MC-MDSS). The basic idea in MC-MDIS is to carry part of the information, named carrier bits, through idle subcarrier selection while transmitting the ordinary bits regularly on all the other subcarriers. When the number of subcarriers is much larger than the adopted constellation size, higher spectral and power efficiency can be achieved comparing with OFDM. In MC-MDSS, the idle subcarriers are replaced by strengthened ones, which, unlike idle ones, can carry both carrier bits and ordinary bits. Therefore, MC-MDSS achieves even higher spectral efficiency than MC-MDIS.Second, we consider jamming-resistant OFDM system design under full-band disguised jamming, where the jamming symbols are taken from the same constellation as the information symbols over each subcarrier. It is shown that due to the symmetricity between the authorized signal and jamming, the BER of the traditional OFDM system is lower bounded by a modulation specific constant. We develop an optimal precoding scheme, which minimizes the BER of OFDM systems under full-band disguised jamming. It is shown that the most efficient way to combat full-band disguised jamming is to concentrate the total available power and distribute it uniformly over a particular number of subcarriers instead of the entire spectrum. The precoding scheme is further randomized to reinforce the system jamming resistance.Third, we consider jamming mitigation for CDMA systems under disguised jamming, where the jammer generates a fake signal using the same spreading code, constellation and pulse shaping filter as that of the authorized signal. Again, due to the symmetricity between the authorized signal and jamming, the receiver cannot really distinguish the authorized signal from jamming, leading to complete communication failure. In this research, instead of using conventional scrambling codes, we apply advanced encryption standard (AES) to generate the security-enhanced scrambling codes. Theoretical analysis shows that: the capacity of conventional CDMA systems without secure scrambling under disguised jamming is actually zero, while the capacity can be significantly increased by secure scrambling.Finally, we consider a game between a power-limited authorized user and a power-limited jammer, who operate independently over the same spectrum consisting of multiple bands. The strategic decision-making is modeled as a two-party zero-sum game, where the payoff function is the capacity that can be achieved by the authorized user in presence of the jammer. We first investigate the game under AWGN channels. It is found that: either for the authorized user to maximize its capacity, or for the jammer to minimize the capacity of the authorized user, the best strategy is to distribute the power uniformly over all the available spectrum. Then, we consider fading channels. We characterize the dynamic relationship between the optimal signal power allocation and the optimal jamming power allocation, and propose an efficient two-step water pouring algorithm to calculate them.
Show less

Title: Kernel methods for biosensing applications
Creator: Khan, Hassan Aqeel
Date: 2015
Collection: Electronic Theses & Dissertations
Description: This thesis examines the design noise robust information retrieval techniques basedon kernel methods. Algorithms are presented for two biosensing applications: (1)High throughput protein arrays and (2) Non-invasive respiratory signal estimation.Our primary objective in protein array design is to maximize the throughput byenabling detection of an extremely large number of protein targets while using aminimal number of receptor spots. This is accomplished by viewing the proteinarray as a...
Show moreThis thesis examines the design noise robust information retrieval techniques basedon kernel methods. Algorithms are presented for two biosensing applications: (1)High throughput protein arrays and (2) Non-invasive respiratory signal estimation.Our primary objective in protein array design is to maximize the throughput byenabling detection of an extremely large number of protein targets while using aminimal number of receptor spots. This is accomplished by viewing the proteinarray as a communication channel and evaluating its information transmission capacity as a function of its receptor probes. In this framework, the channel capacitycan be used as a tool to optimize probe design; the optimal probes being the onesthat maximize capacity. The information capacity is first evaluated for a small scaleprotein array, with only a few protein targets. We believe this is the first effort toevaluate the capacity of a protein array channel. For this purpose models of theproteomic channel's noise characteristics and receptor non-idealities, based on experimental prototypes, are constructed. Kernel methods are employed to extend thecapacity evaluation to larger sized protein arrays that can potentially have thousandsof distinct protein targets. A specially designed kernel which we call the ProteomicKernel is also proposed. This kernel incorporates knowledge about the biophysicsof target and receptor interactions into the cost function employed for evaluation of channel capacity.For respiratory estimation this thesis investigates estimation of breathing-rateand lung-volume using multiple non-invasive sensors under motion artifact and highnoise conditions. A spirometer signal is used as the gold standard for evaluation oferrors. A novel algorithm called the segregated envelope and carrier (SEC) estimation is proposed. This algorithm approximates the spirometer signal by an amplitudemodulated signal and segregates the estimation of the frequency and amplitude in-formation. Results demonstrate that this approach enables effective estimation ofboth breathing rate and lung volume. An adaptive algorithm based on a combination of Gini kernel machines and wavelet filltering is also proposed. This algorithm is titledthe wavelet-adaptive Gini (or WAGini) algorithm, it employs a novel wavelet trans-form based feature extraction frontend to classify the subject's underlying respiratorystate. This information is then employed to select the parameters of the adaptive kernel machine based on the subject's respiratory state. Results demonstrate significantimprovement in breathing rate estimation when compared to traditional respiratoryestimation techniques.
Show less

Title: High-dimensional learning from random projections of data through regularization and diversification
Creator: Aghagolzadeh, Mohammad
Date: 2015
Collection: Electronic Theses & Dissertations
Description: Random signal measurement, in the form of random projections of signal vectors, extends the traditional point-wise and periodic schemes for signal sampling. In particular, the well-known problem of sensing sparse signals from linear measurements, also known as Compressed Sensing (CS), has promoted the utility of random projections. Meanwhile, many signal processing and learning problems that involve parametric estimation do not consist of sparsity constraints in their original forms. With the...
Show moreRandom signal measurement, in the form of random projections of signal vectors, extends the traditional point-wise and periodic schemes for signal sampling. In particular, the well-known problem of sensing sparse signals from linear measurements, also known as Compressed Sensing (CS), has promoted the utility of random projections. Meanwhile, many signal processing and learning problems that involve parametric estimation do not consist of sparsity constraints in their original forms. With the increasing popularity of random measurements, it is crucial to study the generic estimation performance under the random measurement model. In this thesis, we consider two specific learning problems (named below) and present the following two generic approaches for improving the estimation accuracy: 1) by adding relevant constraints to the parameter vectors and 2) by diversification of the random measurements to achieve fast decaying tail bounds for the empirical risk function.The first problem we consider is Dictionary Learning (DL). Dictionaries are extensions of vector bases that are specifically tailored for sparse signal representation. DL has become increasingly popular for sparse modeling of natural images as well as sound and biological signals, just to name a few. Empirical studies have shown that typical DL algorithms for imaging applications are relatively robust with respect to missing pixels in the training data. However, DL from random projections of data corresponds to an ill-posed problem and is not well-studied. Existing efforts are limited to learning structured dictionaries or dictionaries for structured sparse representations to make the problem tractable. The main motivation for considering this problem is to generate an adaptive framework for CS of signals that are not sparse in the signal domain. In fact, this problem has been referred to as 'blind CS' since the optimal basis is subject to estimation during CS recovery. Our initial approach, similar to some of the existing efforts, involves adding structural constraints on the dictionary to incorporate sparse and autoregressive models. More importantly, our results and analysis reveal that DL from random projections of data, in its unconstrained form, can still be accurate given that measurements satisfy the diversity constraints defined later.The second problem that we consider is high-dimensional signal classification. Prior efforts have shown that projecting high-dimensional and redundant signal vectors onto random low-dimensional subspaces presents an efficient alternative to traditional feature extraction tools such as the principle component analysis. Hence, aside from the CS application, random measurements present an efficient sampling method for learning classifiers, eliminating the need for recording and processing high-dimensional signals while most of the recorded data is discarded during feature extraction. We work with the Support Vector Machine (SVM) classifiers that are learned in the high-dimensional ambient signal space using random projections of the training data. Our results indicate that the classifier accuracy can be significantly improved by diversification of the random measurements.
Show less

Title: Adaptive independent component analysis : theoretical formulations and application to CDMA communication system with electronics implementation
Creator: Albataineh, Zaid
Date: 2014
Collection: Electronic Theses & Dissertations
Description: Blind Source Separation (BSS) is a vital unsupervised stochastic area that seeks to estimate the underlying source signals from their mixtures with minimal assumptions about the source signals and/or the mixing environment. BSS has been an active area of research and in recent years has been applied to numerous domains including biomedical engineering, image processing, wireless communications, speech enhancement, remote sensing, etc. Most recently, Independent Component Analysis (ICA) has...
Show moreBlind Source Separation (BSS) is a vital unsupervised stochastic area that seeks to estimate the underlying source signals from their mixtures with minimal assumptions about the source signals and/or the mixing environment. BSS has been an active area of research and in recent years has been applied to numerous domains including biomedical engineering, image processing, wireless communications, speech enhancement, remote sensing, etc. Most recently, Independent Component Analysis (ICA) has become a vital analytical approach in BSS. In spite of active research in BSS, however, many foundational issues still remain in regards to convergence speed, performance quality and robustness in realistic or adverse environments. Furthermore, some of the developed BSS methods are computationally expensive, sensitive to additive and background noise, and not suitable for a real4time or real world implementation. In this thesis, we first formulate new effective ICA4based measures and their corresponding robust adaptive algorithms for the BSS in dynamic "convolutive mixture" environments. We demonstrate their superior performance to present competing algorithms. Then we tailor their application within wireless (CDMA) communication systems and Acoustic Separation Systems. We finally explore a system realization of one of the developed algorithms among ASIC or FPGA platforms in terms of real time speed, effectiveness, cost, and economics of scale. Firstly, we propose a new class of divergence measures for Independent Component Analysis (ICA) for estimating sources from mixtures. The Convex Cauchy4Schwarz Divergence (CCS4DIV) is formed by integrating convex functions into the Cauchy4Schwarz inequality. The new measure is symmetric and convex with respect to the joint probability, where the degree of convexity can be tuned by a (convexity) parameter. A non4parametric (ICA) algorithm generated from the proposed divergence is developed exploiting convexity parameters and employing the Parzen window4based distribution estimates. The new contrast function results in effective parametric and non4parametric ICA4based computational algorithms. Moreover, two pairwise iterative schemes are proposed to tackle the high dimensionality of sources. Secondly, a new blind detection algorithm, based on fourth order cumulant matrices, is presented and applied to the multi4user symbol estimation problem in Direct Sequence Code Division Multiple Access (DS4CDMA) systems. In addition, we propose three new blind receiver schemes, which are based on the state space structures. These so4called blind state4space receivers (BSSR) do not require knowledge of the propagation parameters or spreading code sequences of the users but relies on the statistical independence assumption among the source signals. Lastly, system realization of one of the developed algorithms has been explored among ASIC or FPGA platforms in terms of cost, effectiveness, and economics of scale. Based on our findings of current stat4of4the4art electronics, programmable FPGA designs are deemed to be the most effective technology to be used for ICA hardware implementation at this time.In this thesis, we first formulate new effective ICA-based measures and their corresponding robust adaptive algorithms for the BSS in dynamic "convolutive mixture" environments. We demonstrate their superior performance to present competing algorithms. Then we tailor their application within wireless (CDMA) communication systems and Acoustic Separation Systems. We finally explore a system realization of one of the developed algorithms among ASIC or FPGA platforms in terms of real time speed, effectiveness, cost, and economics of scale.We firstly investigate several measures which are more suitable for extracting different source types from different mixing environments in the learning system. ICA for instantaneous mixtures has been studied here as an introduction to the more realistic convolutive mixture environments. Convolutive mixtures have been investigated in the time/frequency domains and we demonstrate that our approaches succeed in resolving the standing problem of scaling and permutation ambiguities in present research. We propose a new class of divergence measures for Independent Component Analysis (ICA) for estimating sources from mixtures. The Convex Cauchy-Schwarz Divergence (CCS-DIV) is formed by integrating convex functions into the Cauchy-Schwarz inequality. The new measure is symmetric and convex with respect to the joint probability, where the degree of convexity can be tuned by a (convexity) parameter. A non-parametric (ICA) algorithm generated from the proposed divergence is developed exploiting convexity parameters and employing the Parzen window-based distribution estimates. The new contrast function results in effective parametric and non-parametric ICA-based computational algorithms. Moreover, two pairwise iterative schemes are proposed to tackle the high dimensionality of sources. These wo pairwise non-parametric ICA algorithms are based on the new high-performance Convex Cauchy-Schwarz Divergence (CCS-DIV). These two schemes enable fast and efficient de-mixing of sources in real-world applications where the dimensionality of the sources is higher than two.Secondly, the more challenging problem in communication signal processing is to estimate the source signals and their channels in the presence of other co-channel signals and noise without the use of a training set. Blind techniques are promising to integrate and optimize the wireless communication designs i.e. equalizers/ filters/ combiners through its potential in suppressing the inter-symbol interference (ISI), adjacent channel interference, co-channel and the multi access interference MAI. Therefore, a new blind detection algorithm, based on fourth order cumulant matrices, is presented and applied to the multi-user symbol estimation problem in Direct Sequence Code Division Multiple Access (DS-CDMA) systems. The blind detection is to estimate multiple symbol sequences in the downlink of a DS-CDMA communication system using only the received wireless data and without any knowledge of the user spreading codes. The proposed algorithm takes advantage of higher cumulant matrix properties to reduce the computational load and enhance performance. In addition, we address the problem of blind multiuser equalization in the wideband CDMA system, in the noisy multipath propagation environment. Herein, we propose three new blind receiver schemes, which are based on the state space structures. These so-called blind state-space receivers (BSSR) do not require knowledge of the propagation parameters or spreading code sequences of the users but relies on the statistical independence assumption among the source signals. We then develop and derive three update-laws in order to enhance the performance of the blind detector. Also, we upgrade three semi-blind adaptive detectors based on the incorporation of the RAKE receiver and the stochastic gradient algorithms which are used in several blind adaptive signal processing algorithms, namely FastICA, RobustICA, and principle component analysis PCA. Through simulation evidence, we verify the significant bit error rate (BER) and computational speed improvements achieved by these algorithms in comparison to other leading algorithms.Lastly, system realization of one of the developed algorithms has been explored among ASIC or FPGA platforms in terms of cost, effectiveness, and economics of scale. Based on our findings of current stat-of-the-art electronics, programmable FPGA designs are deemed to be the most effective technology to be used for ICA hardware implementation at this time.
Show less

Title: Scalable pulsed mode computation architecture using integrate and fire structure based on margin propagation
Creator: Hindo, Thamira
Date: 2014
Collection: Electronic Theses & Dissertations
Description: Neuromorphic computing architectures mimic the brain to implement efficient computations for sensory applications in a different way from that of the traditional Von Neumann architecture. The goal of neuromorphic computing systems is to implement sensory devices and systems that operate as efficiently as their biological equivalents. Neuromorphic computing consists of several potential components including parallel processing instead of synchronous processing, hybrid (pulse) computation...
Show moreNeuromorphic computing architectures mimic the brain to implement efficient computations for sensory applications in a different way from that of the traditional Von Neumann architecture. The goal of neuromorphic computing systems is to implement sensory devices and systems that operate as efficiently as their biological equivalents. Neuromorphic computing consists of several potential components including parallel processing instead of synchronous processing, hybrid (pulse) computation instead of digital computation, neuron models as a basic core of the processing instead of the arithmetic logic units, and analog VLSI design instead of digital VLSI design. In this work a new neuromorphic computing architecture is proposed and investigated for the implementation of algorithms based on using the pulsed mode with a neuron-based circuit.The proposed architecture goal is to implement approximate non-linear functions that are important components of signal processing algorithms. Some of the most important signal processing algorithms are those that mimic biological systems such as hearing, sight and touch. The designed architecture is pulse mode and it maps the functions into an algorithm called margin propagation. The designed structure is a special network of integrate-and-fire neuron-based circuits that implement the margin propagation algorithm using integration and threshold operations embedded in the transfer function of the neuron model. The integrate-and-fire neuron units in the network are connected together through excitatory and inhibitory paths to impose constraints on the network firing-rate. The advantages of the pulse-based, integrate-and-fire margin propagation (IFMP) algorithmic unit are to implement complex non-linear and dynamic programming functions in a scalable way; to implement functions using cascaded design in parallel or serial architecture; to implement the modules in low power and small size circuits of analog VLSI; and to achieve a wide dynamic range since the input parameters of IFMP module are mapped in the logarithmic domain.The newly proposed IFMP algorithmic unit is investigated both on a theoretically basis and an experimental performance basis. The IFMP algorithmic unit is implemented with a low power analog circuit. The circuit is simulated using computer aided design tools and it is fabricated in a 0.5 micron CMOS process. The hardware performance of the fabricated IFMP algorithmic architecture is also measured. The application of the IFMP algorithmic architecture is investigate for three signal processing algorithms including sequence recognition, trace recognition using hidden Markov model and binary classification using a support vector machine. Additionally, the IFMP architecture is investigated for the application of the winner-take-all algorithm, which is important for hearing, sight and touch sensor systems.
Show less

Title: Stochastic modeling of routing protocols for cognitive radio networks
Creator: Soltani, Soroor
Date: 2013
Collection: Electronic Theses & Dissertations
Description: Cognitive radios are expected torevolutionize wireless networking because of their ability tosense, manage and share the mobile available spectrum.Efficient utilization of the available spectrum could be significantly improved by incorporating different cognitive radio based networks. Challenges are involved in utilizing the cognitive radios in a network, most of which rise from the dynamic nature of available spectrum that is not present in traditional wireless networks. The set of available...
Show moreCognitive radios are expected torevolutionize wireless networking because of their ability tosense, manage and share the mobile available spectrum.Efficient utilization of the available spectrum could be significantly improved by incorporating different cognitive radio based networks. Challenges are involved in utilizing the cognitive radios in a network, most of which rise from the dynamic nature of available spectrum that is not present in traditional wireless networks. The set of available spectrum blocks(channels) changes randomly with the arrival and departure of the users licensed to a specific spectrum band. These users are known as primary users. If a band is used by aprimary user, the cognitive radio alters its transmission power level ormodulation scheme to change its transmission range and switches to another channel.In traditional wireless networks, a link is stable if it is less prone to interference. In cognitive radio networks, however, a link that is interference free might break due to the arrival of its primary user. Therefore, links' stability forms a stochastic process with OFF and ON states; ON, if the primary user is absent. Evidently, traditional network protocols fail in this environment. New sets of protocols are needed in each layer to cope with the stochastic dynamics of cognitive radio networks.In this dissertation we present a comprehensive stochastic framework and a decision theory based model for the problem of routing packets from a source to a destination in a cognitive radio network. We begin by introducing two probability distributions called ArgMax and ArgMin for probabilistic channel selection mechanisms, routing, and MAC protocols. The ArgMax probability distribution locates the most stable link from a set of available links. Conversely, ArgMin identifies the least stable link. ArgMax and ArgMin together provide valuable information on the diversity of the stability of available links in a spectrum band. Next, considering the stochastic arrival of primary users, we model the transition of packets from one hop to the other by a Semi-Markov process and develop a Primary Spread Aware Routing Protocol (PSARP) that learns the dynamics of the environment and adapts its routing decision accordingly. Further, we use a decision theory framework. A utility function is designed to capture the effect of spectrum measurement, fluctuation of bandwidth availability and path quality. A node cognitively decides its best candidate among its neighbors by utilizing a decision tree. Each branch of the tree is quantified by the utility function and a posterior probability distribution, constructed using ArgMax probability distribution, which predicts the suitability of available neighbors. In DTCR (Decision Tree Cognitive Routing), nodes learn their operational environment and adapt their decision making accordingly. We extend the Decision tree modeling to translate video routing in a dynamic cognitive radio network into a decision theory problem. Then terminal analysis backward induction is used to produce our routing scheme that improves the peak signal-to-noise ratio of the received video.We show through this dissertation that by acknowledging the stochastic property of the cognitive radio networks' environment and constructing strategies using the statistical and mathematical tools that deal with such uncertainties, the utilization of these networks will greatly improve.
Show less

Title: Nanoengineered tissue scaffolds for regenerative medicine in neural cell systems
Creator: Tiryaki, Volkan Mujdat
Date: 2013
Collection: Electronic Theses & Dissertations
Description: Central nervous system (CNS) injuries present one of the most challenging problems. Regeneration in the mammal CNS is often limited because the injured axons cannot regenerate beyond the lesion. Implantation of a scaffolding material is one of the possible approaches to this problem. Recent implantations by our collaborative research group using electrospun polyamide nanofibrillar scaffolds have shown promising results in vitro and in vivo. The physical properties of the tissue scaffolds have...
Show moreCentral nervous system (CNS) injuries present one of the most challenging problems. Regeneration in the mammal CNS is often limited because the injured axons cannot regenerate beyond the lesion. Implantation of a scaffolding material is one of the possible approaches to this problem. Recent implantations by our collaborative research group using electrospun polyamide nanofibrillar scaffolds have shown promising results in vitro and in vivo. The physical properties of the tissue scaffolds have been neglected for many years, and it has only recently been recognized that significant aspects include nanophysical properties such as nanopatterning, surface roughness, local elasticity, surface polarity, surface charge, and growth factor presentation as well as the better-known biochemical cues.The properties of: surface polarity, surface roughness, local elasticity and local work of adhesion were investigated in this thesis. The physical and nanophysical properties of the cell culture environments were evaluated using contact angle and atomic force microscopy (AFM) measurements. A new capability, scanning probe recognition microscopy (SPRM), was also used to characterize the surface roughness of nanofibrillar scaffolds. The corresponding morphological and protein expression responses of rat model cerebral cortical astrocytes to the polyamide nanofibrillar scaffolds versus comparative culture surfaces were investigated by AFM and immunocytochemistry. Astrocyte morphological responses were imaged using AFM and phalloidin staining for F-actin. Activation of the corresponding Rho GTPase regulators was investigated using immunolabeling with Cdc42, Rac1, and RhoA. The results supported the hypothesis that the extracellular environment can trigger preferential activation of members of the Rho GTPase family, with demonstrable morphological consequences for cerebral cortical astrocytes. Astrocytes have a special role in the formation of the glial scar in response to traumatic injury. The glial scar biomechanically and biochemically blocks axon regeneration, resulting in paralysis. Astrocytes involved in glial scar formation become reactive, with development of specific morphologies and inhibitory protein expressions. Dibutyryl cyclic adenosine monophosphate (dBcAMP) was used to induce astrocyte reactivity. The directive importance of nanophysical properties for the morphological and protein expression responses of dBcAMP-stimulated cerebral cortical astrocytes was investigated by immunocytochemistry, Western blotting, and AFM. Nanofibrillar scaffold properties were shown to reduce immunoreactivity responses, while PLL Aclar properties were shown to induce responses reminiscent of glial scar formation. Comparison of the responses for dBcAMP-treated reactive-like and untreated astrocytes indicated that the most influential directive nanophysical cues may differ in wound-healing versus untreated situations.Finally, a new cell shape index (CSI) analysis system was developed using volumetric AFM height images of cells cultured on different substrates. The new CSI revealed quantitative cell spreading information not included in the conventional CSI. The system includes a floating feature selection algorithm for cell segmentation that uses a total of 28 different textural features derived from two models: the gray level co-occurance matrix and local statistics texture features. The quantitative morphometry of untreated and dBcAMP-treated cerebral cortical astrocytes was investigated using the new and conventional CSI, and the results showed that quantitative astrocyte spreading and stellation behavior was induced by variations in nanophysical properties.
Show less

Title: Tracking single-units in chronic neural recordings for brain machine interface applications
Creator: Eleryan, Ahmed Ibrahim
Date: 2013
Collection: Electronic Theses & Dissertations
Description: Ensemble recording of multiple single-unit activity has been used to study the mechanisms of neural population coding over prolonged periods of time, and to perform reliable neural decoding in neuroprosthetic motor control applications. However, there are still many challenges towards achieving reliable stable single-units recordings. One primary challenge is the variability in spike waveform features and firing characteristics of single units recorded using chronically implanted...
Show moreEnsemble recording of multiple single-unit activity has been used to study the mechanisms of neural population coding over prolonged periods of time, and to perform reliable neural decoding in neuroprosthetic motor control applications. However, there are still many challenges towards achieving reliable stable single-units recordings. One primary challenge is the variability in spike waveform features and firing characteristics of single units recorded using chronically implanted microelectrodes, making it challenging to ascertain the identity of the recorded neurons across days. In this study, I present a fast and efficient algorithm that tracks multiple single-units recorded in non-human primates performing brain control of a robotic limb, based on features extracted from units' average waveforms and interspike intervals histograms. The algorithm requires a relatively short recording duration to perform the analysis and can be applied at the start of each recording session without requiring the subject to be engaged in a behavioral task. The algorithm achieves a classification accuracy of up to 90% compared to manual tracking. I also explore using the algorithm to develop an automated technique for unit selection to perform reliable decoding of movement parameters from neural activity.
Show less

Title: Reducing the number of ultrasound array elements with the matrix pencil method
Creator: Sales, Kirk L.
Date: 2012
Collection: Electronic Theses & Dissertations
Description: Phased arrays are diversely applied with some specific areas including biomedical imaging and therapy, non-destructive testing, radar and sonar. In this thesis, the matrix pencil method is employed to reduce the number of elements in a linear ultrasound phased array. The non-iterative, linear method begins with a specified pressure beam pattern, reduces the dimensionality of the problem, then calculates the element locations and apodization of a reduced array. Computer simulations demonstrate...
Show morePhased arrays are diversely applied with some specific areas including biomedical imaging and therapy, non-destructive testing, radar and sonar. In this thesis, the matrix pencil method is employed to reduce the number of elements in a linear ultrasound phased array. The non-iterative, linear method begins with a specified pressure beam pattern, reduces the dimensionality of the problem, then calculates the element locations and apodization of a reduced array. Computer simulations demonstrate a close comparison between the initial array beam pattern and the reduced array beam pattern for four different linear arrays. The number of elements in a broadside-steered linear array is shown to decrease by approximately 50% with the reduced array beam pattern closely approximating the initial array beam pattern in the far-field. While the method returns a slightly tapered spacing between elements, for the arrays considered, replacing the tapered spacing with a suitably-selected uniform spacing provides very little change in the main beam and low-angle side lobes.
Show less

Title: A multivariate time-frequency based phase synchrony measure and applications to dynamic brain network analysis
Creator: Mutlu, Ali Yener
Date: 2012
Collection: Electronic Theses & Dissertations
Description: Irregular, non-stationary, and noisy multichannel data are abound in many fields of research. Observations of multichannel data in nature include changes in weather, the dynamics of satellites in the solar system, the time evolution of the magnetic field of celestial bodies, population growth in ecology and the dynamics of the action potentials in neurons.One particular application of interest is the functional integration of neuronal networks in the human brain. Human brain is known to be...
Show moreIrregular, non-stationary, and noisy multichannel data are abound in many fields of research. Observations of multichannel data in nature include changes in weather, the dynamics of satellites in the solar system, the time evolution of the magnetic field of celestial bodies, population growth in ecology and the dynamics of the action potentials in neurons.One particular application of interest is the functional integration of neuronal networks in the human brain. Human brain is known to be one of the most complex biological systems and quantifying functional neural coordination in the brain is a fundamental problem. It has been recently proposed that networks of highly nonlinear and non-stationary reciprocal interactions are the key features of functional integration. Among many linear and nonlinear measures of dependency, time-varying phase synchrony has been proposed as a promising measure of connectivity. Current state-of-the-art in time-varying phase estimation uses either the Hilbert transform or the complex wavelet transform of the signals. Both of these methods have some major drawbacks such as the assumption that the signals are narrowband for the Hilbert transform and the non-uniform time-frequency resolution inherent to the wavelet analysis. Furthermore, the current phase synchrony measures are limited to quantifying bivariate relationships and do not reveal any information about multivariate synchronization patterns which are important for understanding the underlying oscillatory networks.In this dissertation, a new phase estimation method based on the Rihaczek distribution and Reduced Interference Rihaczek distribution belonging to Cohen's class is proposed. These distributions offer phase estimates with uniformly high time-frequency resolution which can be used for defining time and frequency dependent phase synchrony within the same frequency band as well as across different frequency bands. Properties of the phase estimator and the corresponding phase synchrony measure are evaluated both analytically and through simulations showing the effectiveness of the new measures compared to existing ones. The proposed distribution is then extended to quantify the cross-frequency phase synchronization between two signals across different frequencies. In addition, a cross frequency-spectral lag distribution is introducedto quantify the amount of amplitude modulation between signals. Furthermore, the notion of bivariate synchrony is extended to multivariate synchronization to quantify the relationships within and across groups of signals. Measures of multiple correlation and complexity are used as well as a more direct multivariate synchronization measure, `Hyperspherical Phase Synchrony', is proposed. This new measure is based on computing pairwise phase differences to create a multidimensional phase difference vector and mapping this vector to a high dimensional space. Hyperspherical phase synchrony offers lower computational complexity and is more robust to noise compared to the existing measures.Finally, a subspace analysis framework is proposed for studying time-varying evolution of functional brain connectivity. The proposed approach identifies event intervals accounting for the underlying neurophysiological events and extracts key graphs for describing the particular intervals with minimal redundancy. Results from the application to EEG data indicate the effectiveness of the proposed framework in determining the event intervals and summarizing brain activity with a few number of representative graphs.
Show less

Title: Theory, synthesis and implementation of current-mode CMOS piecewise-linear circuits using margin propagation
Creator: Gu, Ming
Date: 2012
Collection: Electronic Theses & Dissertations
Description: Achieving high energy-efficiency is a key requirement for many emerging smart sensors and portable computing systems. While digital signal processing (DSP) has been the de-facto technique for implementing ultra-low power systems, analog signal processing (ASP) provides an attractive and alternate approach that can not only achieve high energy efficiency but also high computational density. Conventional ASP techniques are based on a top-down design approach, where proven mathematical...
Show moreAchieving high energy-efficiency is a key requirement for many emerging smart sensors and portable computing systems. While digital signal processing (DSP) has been the de-facto technique for implementing ultra-low power systems, analog signal processing (ASP) provides an attractive and alternate approach that can not only achieve high energy efficiency but also high computational density. Conventional ASP techniques are based on a top-down design approach, where proven mathematical principles and related algorithms are mapped and emulated using computational primitives inherent in the device physics. An example being the translinear principle, which is the state-of-the-art ASP technique, that uses the exponential current-to-voltage characteristics for designing ultra-low-power analog processors. However, elegant formulations could result from a bottom-up approach where device and bias independent computational primitives (e.g. current and charge conservation principles) are used for designing "approximate" analog signal processors. The hypothesis of this proposal is that many signal processing algorithms exhibit an inherent calibration ability due to which their performance remains unaffected by the use of "approximate" analog computing techniques. In this research, we investigate the theory, synthesis and implementation of high performance analog processors using a novel piecewise-linear (PWL) approximation algorithm called margin propagation (MP). MP principle utilizes only basic conservation laws of physical quantities (current, charge, mass, energy) for computing and therefore is scalable across devices (silicon, MEMS, microfluidics). However, there are additional advantages of MP-based processors when implemented using CMOS current-mode circuits, which includes: 1) the operation of the MP processor requires only addition, subtraction and threshold operations and hence is independent of transistor biasing (weak, moderate and strong inversion) and robust to variations in environmental conditions (e.g. temperature); and 2) improved dynamic range and faster convergence as compared to the translinear implementations. We verify our hypothesis using two analog signal processing applications: (a) design of high-performance analog low-density parity check (LDPC) decoders for applications in sensor networks; and (b) design of ultra-low-power analog support vector machines (SVM) for smart sensors. Our results demonstrate that an algorithmic framework for designing margin propagation (MP) based LDPC decoders can be used to trade-off its BER performance with its energy efficiency, making the design attractive for applications with adaptive energy-BER constraints. We have verified this trade-off using an analog current-mode implementation of an MP-based (32,8) LDPC decoder. Measured results from prototypes fabricated in a 0.5 μm CMOS process show that the BER performance of the MP-based decoder outperforms a benchmark state-of-the-art min-sum decoder at SNR levels greater than 3.5 dB and can achieve energy efficiencies greater than 100pJ/bit at a throughput of 12.8 Mbps. In the second part of this study, MP principle is used for designing an energy-scalable support vector machine (SVM) whose power and speed requirements can be configured dynamically without any degradation in performance. We have verified the energy-scaling property using a current-mode implementation of an SVM operating with 8 dimensional feature vectors and 18 support vectors. The prototype fabricated in a 0.5μm CMOS process has integrated an array of floating gate transistors that serve as storage for up to 2052 SVM parameters. The SVM prototype also integrates novel circuits that have been designed for interfacing with an external digital processor. This includes a novel current-input current-output logarithmic amplifier circuit that can achieve a dynamic range of 120dB while consuming nanowatts of power. Another novel circuit includes a varactor based temperature compensated floating-gate memory that demonstrates a superior programming range than other temperature compensated floating-gate memories.
Show less

MSU Libraries

Digital Repository

Enabled Filters

Pages

Pages

MSU Libraries

Digital Repository

You are here

Search results

Pages

Pages