Search results

Title: Finding optimized bounding boxes of polytopes in d-dimensional space and their properties in k-dimensional projections
Creator: Shahid, Salman (Of Michigan State University)
Date: 2014
Collection: Electronic Theses & Dissertations
Description: Using minimal bounding boxes to encapsulate or approximate a set of points in d-dimensional space is a non-trivial problem that has applications in a variety of fields including collision detection, object rendering, high dimensional databases and statistical analysis to name a few. While a significant amount of work has been done on the three dimensional variant of the problem (i.e. finding the minimum volume bounding box of a set of points in three dimensions), it is difficult to find a...
Show moreUsing minimal bounding boxes to encapsulate or approximate a set of points in d-dimensional space is a non-trivial problem that has applications in a variety of fields including collision detection, object rendering, high dimensional databases and statistical analysis to name a few. While a significant amount of work has been done on the three dimensional variant of the problem (i.e. finding the minimum volume bounding box of a set of points in three dimensions), it is difficult to find a simple method to do the same for higher dimensions. Even in three dimensions existing methods suffer from either high time complexity or suboptimal results with a speed up in execution time. In this thesis we present a new approach to find the optimized minimum bounding boxes of a set of points defining convex polytopes in d-dimensional space. The solution also gives the optimal bounding box in three dimensions with a much simpler implementation while significantly speeding up the execution time for a large number of vertices. The basis of the proposed approach is a series of unique properties of the k-dimensional projections that are leveraged into an algorithm. This algorithm works by constructing the convex hulls of a given set of points and optimizing the projections of those hulls in two dimensional space using the new concept of Simultaneous Local Optimal. We show that the proposed algorithm provides significantly better performances than those of the current state of the art approach on the basis of time and accuracy. To illustrate the importance of the result in terms of a real world application, the optimized bounding box algorithm is used to develop a method for carrying out range queries in high dimensional databases. This method uses data transformation techniques in conjunction with a set of heuristics to provide significant performance improvement.
Show less

Title: Non-coding RNA identification in large-scale genomic data
Creator: Yuan, Cheng
Date: 2014
Collection: Electronic Theses & Dissertations
Description: Noncoding RNAs (ncRNAs), which function directly as RNAs without translating into proteins, play diverse and important biological functions. ncRNAs function not only through their primary structures, but also secondary structures, which are defined by interactions between Watson-Crick and wobble base pairs. Common types of ncRNA include microRNA, rRNA, snoRNA, tRNA. Functions of ncRNAs vary among different types. Recent studies suggest the existence of large number of ncRNA genes....
Show moreNoncoding RNAs (ncRNAs), which function directly as RNAs without translating into proteins, play diverse and important biological functions. ncRNAs function not only through their primary structures, but also secondary structures, which are defined by interactions between Watson-Crick and wobble base pairs. Common types of ncRNA include microRNA, rRNA, snoRNA, tRNA. Functions of ncRNAs vary among different types. Recent studies suggest the existence of large number of ncRNA genes. Identification of novel and known ncRNAs becomes increasingly important in order to understand their functionalities and the underlying communities.Next-generation sequencing (NGS) technology sheds lights on more comprehensive and sensitive ncRNA annotation. Lowly transcribed ncRNAs or ncRNAs from rare species with low abundance may be identified via deep sequencing. However, there exist several challenges in ncRNA identification in large-scale genomic data. First, the massive volume of datasets could lead to very long computation time, making existing algorithms infeasible. Second, NGS has relatively high error rate, which could further complicate the problem. Third, high sequence similarity among related ncRNAs could make them difficult to identify, resulting in incorrect output. Fourth, while secondary structures should be adopted for accurate ncRNA identification, they usually incur high computational complexity. In particular, some ncRNAs contain pseudoknot structures, which cannot be effectively modeled by the state-of-the-art approach. As a result, ncRNAs containing pseudoknots are hard to annotate.In my PhD work, I aimed to tackle the above challenges in ncRNA identification. First, I designed a progressive search pipeline to identify ncRNAs containing pseudoknot structures. The algorithms are more efficient than the state-of-the-art approaches and can be used for large-scale data. Second, I designed a ncRNA classification tool for short reads in NGS data lacking quality reference genomes. The initial homology search phase significantly reduces size of the original input, making the tool feasible for large-scale data. Last, I focused on identifying 16S ribosomal RNAs from NGS data. 16S ribosomal RNAs are very important type of ncRNAs, which can be used for phylogenic study. A set of graph based assembly algorithms were applied to form longer or full-length 16S rRNA contigs. I utilized paired-end information in NGS data, so lowly abundant 16S genes can also be identified. To reduce the complexity of problem and make the tool practical for large-scale data, I designed a list of error correction and graph reduction techniques for graph simplification.
Show less

Title: Semi=supervised learning with side information : graph-based approaches
Creator: Liu, Yi
Date: 2007
Collection: Electronic Theses & Dissertations

Title: TEACHERS IN SOCIAL MEDIA : A DATA SCIENCE PERSPECTIVE
Creator: Karimi, Hamid
Date: 2021
Collection: Electronic Theses & Dissertations
Description: Social media has become an integral part of human life in the 21st century. The number of social media users was estimated to be around 3.6 billion individuals in 2020. Social media platforms (e.g., Facebook) have facilitated interpersonal communication, diffusion of information, the creation of groups and communities, to name a few. As far as education systems are concerned, online social media has transformed and connected traditional social networks within the schoolhouse to a broader and...
Show moreSocial media has become an integral part of human life in the 21st century. The number of social media users was estimated to be around 3.6 billion individuals in 2020. Social media platforms (e.g., Facebook) have facilitated interpersonal communication, diffusion of information, the creation of groups and communities, to name a few. As far as education systems are concerned, online social media has transformed and connected traditional social networks within the schoolhouse to a broader and expanded world outside. In such an expanded virtual space, teachers engage in various activities within their communities, e.g., exchanging instructional resources, seeking new teaching methods, engaging in online discussions. Therefore, given the importance of teachers in social media and its tremendous impact on PK-12 education, in this dissertation, we investigate teachers in social media from a data science perspective. Our investigation in this direction is essentially an interdisciplinary endeavor bridging modern data science and education. In particular, we have made three contributions, as briefly discussed in the following. Current teachers in social media studies suffice to a small number of surveyed teachers while thousands of other teachers are on social media. This hinders us from conducting large-scale data-driven studies pertinent to teachers in social media. Aiming to overcome this challenge and further facilitate data-driven studies related to teachers in social media, we propose a novel method that automatically identifies teachers on Pinterest, an image-based social media popular among teachers. In this framework, we formulate the teacher identification problem as a positive unlabelled (PU) learning where positive samples are surveyed teachers, and unlabelled samples are their online friends. Using our framework, we build the largest dataset of teachers on Pinterest. With this dataset at our disposal, we perform an exploratory analysis of teachers on Pinterest while considering their genders. Our analysis incorporates two crucial aspects of teachers in social media. First, we investigate various online activities of male and female teachers, e.g., topics and sources of their curated resources, the professional language employed to describe their resources. Second, we investigate male and female teachers in the context of the social network (the graph) they belong to, e.g., structural centrality, gender homophily. Our analysis and findings in this part of the dissertation can serve as a valuable reference for many entities concerned with teachers' gender, e.g., principals, state, and federal governments.Finally, in the third part of the dissertation, we shed light on the diffusion of teacher-curated resources on Pinterest. First, we introduce three measures to characterize the diffusion process. Then, we investigate these three measures while considering two crucial characteristics of a resource, e.g., the topic and the source. Ultimately, we investigate how teacher attributes (e.g., the number of friends) affect the diffusion of their resources. The conducted diffusion analysis is the first of its kind and offers a deeper understating of the complex mechanism driving the diffusion of resources curated by teachers on Pinterest.
Show less

Title: Automated Speaker Recognition in Non-ideal Audio Signals Using Deep Neural Networks
Creator: Chowdhury, Anurag
Date: 2021
Collection: Electronic Theses & Dissertations
Description: Speaker recognition entails the use of the human voice as a biometric modality for recognizing individuals. While speaker recognition systems are gaining popularity in consumer applications, most of these systems are negatively affected by non-ideal audio conditions, such as audio degradations, multi-lingual speech, and varying duration audio. This thesis focuses on developing speaker recognition systems robust to non-ideal audio conditions.Firstly, a 1-Dimensional Convolutional Neural...
Show moreSpeaker recognition entails the use of the human voice as a biometric modality for recognizing individuals. While speaker recognition systems are gaining popularity in consumer applications, most of these systems are negatively affected by non-ideal audio conditions, such as audio degradations, multi-lingual speech, and varying duration audio. This thesis focuses on developing speaker recognition systems robust to non-ideal audio conditions.Firstly, a 1-Dimensional Convolutional Neural Network (1D-CNN) is developed to extract noise-robust speaker-dependent speech characteristics from the Mel Frequency Cepstral Coefficients (MFCC). Secondly, the 1D-CNN-based approach is extended to develop a triplet-learning-based feature-fusion framework, called 1D-Triplet-CNN, for improving speaker recognition performance by judiciously combining MFCC and Linear Predictive Coding (LPC) features. Our hypothesis rests on the observation that MFCC and LPC capture two distinct aspects of speech: speech perception and speech production. Thirdly, a time-domain filterbank called DeepVOX is learned from vast amounts of raw speech audio to replace commonly-used hand-crafted filterbanks, such as the Mel filterbank, in speech feature extractors. Finally, a vocal style encoding network called DeepTalk is developed to learn speaker-dependent behavioral voice characteristics to improve speaker recognition performance. The primary contribution of the thesis is the development of deep learning-based techniques to extract discriminative, noise-robust physical and behavioral voice characteristics from non-ideal speech audio. A large number of experiments conducted on the TIMIT, NTIMIT, SITW, NIST SRE (2008, 2010, and 2018), Fisher, VOXCeleb, and JukeBox datasets convey the efficacy of the proposed techniques and their importance in improving speaker recognition performance in non-ideal audio conditions.
Show less

Title: EFFICIENT AND PORTABLE SPARSE SOLVERS FOR HETEROGENEOUS HIGH PERFORMANCE COMPUTING SYSTEMS
Creator: Rabbi, Md Fazlay
Date: 2022
Collection: Electronic Theses & Dissertations
Description: Sparse matrix computations arise in the form of the solution of systems of linear equations, matrix factorization, linear least-squares problems, and eigenvalue problems in numerous computational disciplines ranging from quantum many-body problems, computational fluid dynamics, machine learning and graph analytics. The scale of problems in these scientific applications typically necessitates execution on massively parallel architectures. Moreover, due to the irregular data access patterns and...
Show moreSparse matrix computations arise in the form of the solution of systems of linear equations, matrix factorization, linear least-squares problems, and eigenvalue problems in numerous computational disciplines ranging from quantum many-body problems, computational fluid dynamics, machine learning and graph analytics. The scale of problems in these scientific applications typically necessitates execution on massively parallel architectures. Moreover, due to the irregular data access patterns and low arithmetic intensities of sparse matrix computations, achieving high performance and scalability is very difficult. These challenges are further exacerbated by the increasingly complex deep memory hierarchies of the modern architectures as they typically integrate several layers of memory storage. Data movement is an important bottleneck against efficiency and energy consumption in large-scale sparse matrix computations. Minimizing data movement across layers of the memory and overlapping data movement with computations are keys to achieving high performance in sparse matrix computations. My thesis work contributes towards systematically identifying algorithmic challenges of the sparse solvers and providing optimized and high performing solutions for both shared memory architectures and heterogeneous architectures by minimizing data movements between different memory layers. For this purpose, we first introduce a shared memory task-parallel framework focusing on optimizing the entire solvers rather than a specific kernel. As most of the recent (or upcoming) supercomputers are equipped with Graphics Processing Unit (GPU), we decided to evaluate the efficacy of the directive-based programming models (i.e., OpenMP and OpenACC) in offloading computations on GPU to achieve performance portability. Being inspired by the promising results of this work, we port and optimize our shared memory task-parallel framework on GPU accelerated systems to execute problem sizes that exceed device memory.
Show less

Title: EXTENDED REALITY (XR) & GAMIFICATION IN THE CONTEXT OF THE INTERNET OF THINGS (IOT) AND ARTIFICIAL INTELLIGENCE (AI)
Creator: Pappas, Georgios
Date: 2021
Collection: Electronic Theses & Dissertations
Description: The present research develops a holistic framework for and way of thinking about Deep Technologies related to Gamification, eXtended Reality (XR), the Internet of Things (IoT), and Artificial Intelligence (AI). Starting with the concept of gamification and the immersive technology of XR, we create interconnections with the IoT and AI implementations. While each constituent technology has its own unique impact, our approach uniquely addresses the combinational potential of these technologies...
Show moreThe present research develops a holistic framework for and way of thinking about Deep Technologies related to Gamification, eXtended Reality (XR), the Internet of Things (IoT), and Artificial Intelligence (AI). Starting with the concept of gamification and the immersive technology of XR, we create interconnections with the IoT and AI implementations. While each constituent technology has its own unique impact, our approach uniquely addresses the combinational potential of these technologies that may have greater impact than any technology on its own. To approach the research problem more efficiently, the methodology followed includes its initial division into smaller parts. For each part of the research problem, novel applications were designed and developed including gamified tools, serious games and AR/VR implementations. We apply the proposed framework in two different domains: autonomous vehicles (AVs), and distance learning.Specifically, in chapter 2, an innovative hybrid tool for distance learning is showcased where, among others, the fusion with IoT provides a novel pseudomultiplayer mode. This mode may transform advanced asynchronous gamified tools to synchronous by enabling or disabling virtual events and phenomena enhancing the student experience. Next, in Chapter 3, along with gamification, the combination of XR with IoT data streams is presented but this time in an automotive context. We showcase how this fusion of technologies provides low-latency monitoring of vehicle characteristics, and how this can be visualized in augmented and virtual reality using low-cost hardware and services. This part of our proposed framework provides the methodology of creating any type of Digital Twin with near real-time data visualization.Following that, in chapter 4 we establish the second part of the suggested holistic framework where Virtual Environments (VEs), in general, can work as synthetic data generators and thus, be a great source of artificial suitable for training AI models. This part of the research includes two novel implementations the Gamified Digital Simulator (GDS) and the Virtual LiDAR Simulator.Having established the holistic framework, in Chapter 5, we now “zoom in” to gamification exploring deeper aspects of virtual environments and discuss how serious games can be combined with other facets of virtual layers (cyber ranges,virtual learning environments) to provide enhanced training and advanced learning experiences. Lastly, in chapter 6, “zooming out” from gamification an additional enhancement layer is presented. We showcase the importance of human-centered design of via an implementation that tries to simulate the AV-pedestrian interactions in a virtual and safe environment.
Show less

Title: Applying evolutionary computation techniques to address environmental uncertainty in dynamically adaptive systems
Creator: Ramirez, Andres J.
Date: 2013
Collection: Electronic Theses & Dissertations
Description: A dynamically adaptive system (DAS) observes itself and its execution environment at run time to detect conditions that warrant adaptation. If an adaptation is necessary, then a DAS changes its structure and/or behavior to continuously satisfy its requirements, even as its environment changes. It is challenging, however, to systematically and rigorously develop a DAS due to environmental uncertainty. In particular, it is often infeasible for a human to identify all possible combinations of...
Show moreA dynamically adaptive system (DAS) observes itself and its execution environment at run time to detect conditions that warrant adaptation. If an adaptation is necessary, then a DAS changes its structure and/or behavior to continuously satisfy its requirements, even as its environment changes. It is challenging, however, to systematically and rigorously develop a DAS due to environmental uncertainty. In particular, it is often infeasible for a human to identify all possible combinations of system and environmental conditions that a DAS might encounter throughout its lifetime. Nevertheless, a DAS must continuously satisfy its requirements despite the threat that this uncertainty poses to its adaptation capabilities. This dissertation proposes a model-based framework that supports the specification, monitoring, and dynamic reconfiguration of a DAS to explicitly address uncertainty. The proposed framework uses goal-oriented requirements models and evolutionary computation techniques to derive and fine-tune utility functions for requirements monitoring in a DAS, identify combinations of system and environmental conditions that adversely affect the behavior of a DAS, and generate adaptations on-demand to transition the DAS to a target system configuration while preserving system consistency. We demonstrate the capabilities of our model-based framework by applying it to an industrial case study involving a remote data mirroring network that efficiently distributes data even as network links fail and messages are dropped, corrupted, and delayed.
Show less

Title: Towards Robust and Reliable Communication for Millimeter Wave Networks
Creator: Zarifneshat, Masoud
Date: 2022
Collection: Electronic Theses & Dissertations
Description: The future generations of wireless networks benefit significantly from millimeter wave technology (mmW) with frequencies ranging from about 30 GHz to 300 GHz. Specifically, the fifth generation of wireless networks has already implemented the mmW technology and the capacity requirements defined in 6G will also benefit from the mmW spectrum. Despite the attractions of the mmW technology, the mmW spectrum has some inherent propagation properties that introduce challenges. The first is that free...
Show moreThe future generations of wireless networks benefit significantly from millimeter wave technology (mmW) with frequencies ranging from about 30 GHz to 300 GHz. Specifically, the fifth generation of wireless networks has already implemented the mmW technology and the capacity requirements defined in 6G will also benefit from the mmW spectrum. Despite the attractions of the mmW technology, the mmW spectrum has some inherent propagation properties that introduce challenges. The first is that free space pathloss in mmW is more severe than that in the sub 6 GHz band. To make the mmW signal travel farther, communication systems need to use phased array antennas to concentrate the signal power to a limited direction in space at each given time. Directional communication can incur high overhead on the system because it needs to probe the space for finding signal paths. To have efficient communication in the mmW spectrum, the transmitter and the receiver should align their beams on strong signal paths which is a high overhead task. The second is a low diffraction of the mmW spectrum. The low diffraction causes almost any object including the human body to easily block the mmW signal degrading the mmW link quality. Avoiding and recovering from the blockage in the mmW communications, especially in dynamic environments, is particularly challenging because of the fast changes of the mmW channel. Due to the unique characteristics of the mmW propagation, the traditional user association methods perform poorly in the mmW spectrum. Therefore, we propose user association methods that consider the inherent propagation characteristics of the mmW signal. We first propose a method that collects the history of blockage incidents throughout the network and exploits the historical blockage incidents to associate user equipment to the base station with lower blockage possibility. The simulation results show that our proposed algorithm performs better in terms of improving the quality of the links and blockage rate in the network. User association based only on one objective may deteriorate other objectives. Therefore, we formulate a biobjective optimization problem to consider two objectives of load balance and blockage possibility in the network. We conduct Lagrangian dual analysis to decrease time complexity. The results show that our solution to the biobjective optimization problem has a better outcome compared to optimizing each objective alone. After we investigate the user association problem, we further look into the problem of maintaining a robust link between a transmitter and a receiver. The directional propagation of the mmW signal creates the opportunity to exploit multipath for a robust link. The main reasons for the link quality degradation are blockage and link movement. We devise a learning-based prediction framework to classify link blockage and link movement efficiently and quickly using diffraction values for taking appropriate mitigating actions. The simulations show that the prediction framework can predict blockage with close to 90% accuracy. The prediction framework will eliminate the need for time-consuming methods to discriminate between link movement and link blockage. After detecting the reason for the link degradation, the system needs to do the beam alignment on the updated mmW signal paths. The beam alignment on the signal paths is a high overhead task. We propose using signaling in another frequency band to discover the paths surrounding a receiver working in the mmW spectrum. In this way, the receiver does not have to do an expensive beam scan in the mmW band. Our experiments with off-the-shelf devices show that we can use a non-mmW frequency band's paths to align the beams in mmW frequency. In this dissertation, we provide solutions to the fundamental problems in mmW communication. We propose a user association method that is designed for mmW networks considering challenges of mmW signal. A closed-form solution for a biobjective optimization problem to optimize both blockage and load balance of the network is also provided. Moreover, we show that we can efficiently use the out-of-band signal to exploit multipath created in mmW communication. The future research direction includes investigating the methods proposed in this dissertation to solve some of the classic problems in the wireless networks that exist in the mmW spectrum.
Show less

Title: Variational Bayes inference of Ising models and their applications
Creator: Kim, Minwoo
Date: 2022
Collection: Electronic Theses & Dissertations
Description: Ising models originated in statistical physics have been widely used in modeling spatialdata and computer vision problems. However, statistical inference of this model and its application to many practical fields remain challenging due to intractable nature of the normalizing constant in the likelihood. This dissertation consists of two main themes, (1) parameter estimation of Ising model and (2) structured variable selection based on the Ising model using variational Bayes (VB).In Chapter 1,...
Show moreIsing models originated in statistical physics have been widely used in modeling spatialdata and computer vision problems. However, statistical inference of this model and its application to many practical fields remain challenging due to intractable nature of the normalizing constant in the likelihood. This dissertation consists of two main themes, (1) parameter estimation of Ising model and (2) structured variable selection based on the Ising model using variational Bayes (VB).In Chapter 1, we review the background, research questions and development of Isingmodel, variational Bayes, and other statistical concepts. An Ising model basically deal with a binary random vector in which each component is dependent on its neighbors. There exist various versions of Ising model depending on parameterization and neighboring structure. In Chapter 2, with two-parameter Ising model, we describe a novel procedure for the pa- rameter estimation based on VB which is computationally efficient and accurate compared to existing methods. Traditional pseudo maximum likelihood estimate (PMLE) can pro- vide accurate results only for smaller number of neighbors. A Bayesian approach based on Markov chain Monte Carlo (MCMC) performs better even with a large number of neighbors. Computational costs of MCMC, however, are quite expensive in terms of time. Accordingly, we propose a VB method with two variational families, mean-field (MF) Gaussian family and bivariate normal (BN) family. Extensive simulation studies validate the efficacy of the families. Using our VB methods, computing times are remarkably decreased without dete- rioration in performance accuracy, or in some scenarios we get much more accurate output. In addition, we demonstrates theoretical properties of the proposed VB method under MF family. The main theoretical contribution of our work lies in establishing the consistency of the variational posterior for the Ising model with the true likelihood replaced by the pseudo- likelihood. Under certain conditions, we first derive the rates at which the true posterior based on the pseudo-likelihood concentrates around the εn- shrinking neighborhoods of the true parameters. With a suitable bound on the Kullback-Leibler distance between the true and the variational posterior, we next establish the rate of contraction for the variational pos- terior and demonstrate that the variational posterior also concentrates around εn-shrinking neighborhoods of the true parameter.In Chapter 3, we propose a Bayesian variable selection technique for a regression setupin which the regression coefficients hold structural dependency. We employ spike and slab priors on the regression coefficients as follows: (i) In order to capture the intrinsic structure, we first consider Ising prior on latent binary variables. If a latent variable takes one, the corresponding regression coefficient is active, otherwise, it is inactive. (ii) Employing spike and slab prior, we put Gaussian priors (slab) on the active coefficients and inactive coefficients will be zeros with probability one (spike).
Show less

Title: Computational Frameworks for Indel-Aware Evolutionary Analysis using Large-Scale Genomic Sequence Data
Creator: Wang, Wei
Date: 2021
Collection: Electronic Theses & Dissertations
Description: With the development of sequencing techniques, genetic sequencing data has been extensively used in evolutionary studies.The phylogenetic reconstruction problem, which is the reconstruction of evolutionary history from biomolecular sequences, is a fundamental problem. The evolutionary relationship between organisms is often represented by phylogeny, which is a tree or network representation. The most widely-used approach for reconstructing phylogenies from sequencing data involves two phases:...
Show moreWith the development of sequencing techniques, genetic sequencing data has been extensively used in evolutionary studies.The phylogenetic reconstruction problem, which is the reconstruction of evolutionary history from biomolecular sequences, is a fundamental problem. The evolutionary relationship between organisms is often represented by phylogeny, which is a tree or network representation. The most widely-used approach for reconstructing phylogenies from sequencing data involves two phases: multiple sequence alignment and phylogenetic reconstruction from the aligned sequences. As the amount of biomolecular sequence data increases, it has become a major challenge to develop efficient and accurate computational methods for phylogenetic analyses of large-scale sequencing data. Due to the complexity of the phylogenetic reconstruction problem in modern phylogenetic studies, the traditional sequence-based phylogenetic analysis methods involve many over-simplified assumptions. In this thesis, we describe our contribution in relaxing some of these over-simplified assumptions in the phylogenetic analysis.Insertion and deletion events, referred to as indels, carry much phylogenetic information but are often ignored in the reconstruction process of phylogenies. We take into account the indel uncertainties in multiple phylogenetic analyses by applying resampling and re-estimation. Another over-simplified assumption that we contributed to is adopted by many commonly used non-parametric algorithms for the resampling of biomolecular sequences, all sites in an MSA are evolved independently and identically distributed (i.i.d). Many evolution events, such as recombination and hybridization, may produce intra-sequence and functional dependence in biomolecular sequences that violate this assumption. We introduce SERES, a resampling algorithm for biomolecular sequences that can produce resampled replicates that preserve the intra-sequence dependence. We describe the application of the SERES resampling and re-estimation approach to two classical problems: the multiple sequence alignment support estimation and recombination-aware local genealogical inference. We show that these two statistical inference problems greatly benefit from the indel-aware resampling and re-estimation approach and the reservation of intra-sequence dependence.A major drawback of SERES is that it requires parameters to ensure the synchronization of random walks on unaligned sequences.We introduce RAWR, a non-parametric resampling method designed for phylogenetic tree support estimation that does not require extra parameters. We show that the RAWR-based resampling and re-estimation method produces comparable or typically better performance than the traditional bootstrap approach on the phylogenetic tree support estimation problem. We further relax the commonly used assumption of phylogeny.Evolutionary history is usually considered as a tree structure. Evolutionary events that cause reticulated gene flow are ignored. Previous studies show that alignment uncertainty greatly impacts downstream tree inference and learning. However, there is little discussion about the impact of MSA uncertainties on the phylogenetic network reconstruction. We show evidence that the errors introduced in MSA estimation decrease the accuracy of the inferred phylogenetic network, and an indel-aware reconstruction method is needed for phylogenetic network analysis. In this dissertation, we introduce our contribution to phylogenetic estimation using biomolecular sequence data involving complex evolutionary histories, such as sequence insertion and deletion processes and non-tree-like evolution.
Show less

Title: Predicting the Properties of Ligands Using Molecular Dynamics and Machine Learning
Creator: Donyapour, Nazanin
Date: 2022
Collection: Electronic Theses & Dissertations
Description: The discovery and design of new drugs requires extensive experimental assays that are usually very expensive and time-consuming. To cut down the cost and time of the drug development process and help design effective drugs more efficiently, various computational methods have been developed that are referred to collectively as in silico drug design. These in silico methods can be used to not only determine compounds that can bind to a target receptor but to determine whether compounds show...
Show moreThe discovery and design of new drugs requires extensive experimental assays that are usually very expensive and time-consuming. To cut down the cost and time of the drug development process and help design effective drugs more efficiently, various computational methods have been developed that are referred to collectively as in silico drug design. These in silico methods can be used to not only determine compounds that can bind to a target receptor but to determine whether compounds show ideal drug-like properties. I have provided solutions to these problems by developing novel methods for molecular simulation and molecular property prediction. Firstly, we have developed a new enhanced sampling MD algorithm called Resampling of Ensembles by Variation Optimization or “REVO” that can generate binding and unbinding pathways of ligand-target interactions. These pathways are useful for calculating transition rates and Residence Times (RT) of protein-ligand complexes. This can be particularly useful for drug design as studies for some systems show that the drug efficacy correlates more with RT than the binding affinity. This method is generally useful for generating long-timescale transitions in complex systems, including alternate ligand binding poses and protein conformational changes. Secondly, we have developed a technique we refer to as “ClassicalGSG” to predict the partition coefficient (log P) of small molecules. log P is one of the main factors in determining the drug likeness of a compound, as it helps determine bioavailability, solubility, and membrane permeability. This method has been very successful compared to other methods in literature. Finally, we have developed a method called ``Flexible Topology'' that we hope can eventually be used to screen a database of potential ligands while considering ligand-induced conformational changes. After discovering molecules with drug-like properties in the drug design pipeline, Virtual Screening (VS) methods are employed to perform an extensive search on drug databases with hundreds of millions of compounds to find candidates that bind tightly to a molecular target. However, in order for this to be computationally tractable, typically, only static snapshots of the target are used, which cannot respond to the presence of the drug compound. To efficiently capture drug-target interactions during screening, we have developed a machine-learning algorithm that employs Molecular Dynamics (MD) simulations with a protein of interest and a set of atoms called “Ghost Particles”. During the simulation, the Flexible Topology method induces forces that constantly modify the ghost particles and optimizes them toward drug-like molecules that are compatible with the molecular target.
Show less

Title: Robust Learning of Deep Neural Networks under Data Corruption
Creator: Liu, Boyang
Date: 2022
Collection: Electronic Theses & Dissertations
Description: Training deep neural networks in the presence of corrupted data is challenging as the corrupted data points may significantly impact generalization performance of the models. Unfortunately, the data corruption issue widely exists in many application domains, including but not limited to, healthcare, environmental sciences, autonomous driving, and social media analytics. Although there have been some previous studies that aim to enhance the robustness of machine learning models against data...
Show moreTraining deep neural networks in the presence of corrupted data is challenging as the corrupted data points may significantly impact generalization performance of the models. Unfortunately, the data corruption issue widely exists in many application domains, including but not limited to, healthcare, environmental sciences, autonomous driving, and social media analytics. Although there have been some previous studies that aim to enhance the robustness of machine learning models against data corruption, most of them either lack theoretical robustness guarantees or unable to scale to the millions of model parameters governing deep neural networks. The goal of this thesis is to design robust machine learning algorithms that 1) effectively deal with different types of data corruption, 2) have sound theoretical guarantees on robustness, and 3) scalable to large number of parameters in deep neural networks.There are two general approaches to enhance model robustness against data corruption. The first approach is to detect and remove the corrupted data while the second approach is to design robust learning algorithms that can tolerate some fraction of corrupted data. In this thesis, I had developed two robust unsupervised anomaly detection algorithms and two robust supervised learning algorithm for corrupted supervision and backdoor attack. Specifically, in Chapter 2, I proposed the Robust Collaborative Autoencoder (RCA) approach to enhance the robustness of vanilla autoencoder methods against natural corruption. In Chapter 3, I developed Robust RealNVP, a robust density estimation technique for unsupervised anomaly detection tasks given concentrated anomalies. Chapter 4 presents the Provable Robust Learning (PRL) approach, which is a robust algorithm against agnostic corrupted supervision. In Chapter 5, a meta-algorithm to defend against backdoor attacks is proposed by exploring the connection between label corruption and backdoor data poisoning attack. Extensive experiments on multiple benchmark datasets have demonstrated the robustness of the proposed algorithms under different types of corruption.
Show less

Title: The Evolutionary Origins of Cognition : Understanding the early evolution of biological control systems and general intelligence
Creator: Carvalho Pontes, Anselmo
Date: 2021
Collection: Electronic Theses & Dissertations
Description: In the last century, we have made great strides towards understanding natural cognition and recreating it artificially. However, most cognitive research is still guided by an inadequate theoretical framework that equates cognition to a computer system executing a data processing task. Cognition, whether natural or artificial, is not a data processing system; it is a control system.At cognition's core is a value system that allows it to evaluate current conditions and decide among two or more...
Show moreIn the last century, we have made great strides towards understanding natural cognition and recreating it artificially. However, most cognitive research is still guided by an inadequate theoretical framework that equates cognition to a computer system executing a data processing task. Cognition, whether natural or artificial, is not a data processing system; it is a control system.At cognition's core is a value system that allows it to evaluate current conditions and decide among two or more courses of action. Memory, learning, planning, and deliberation, rather than being essential cognitive abilities, are features that evolved over time to support the primary task of deciding “what to do next”. I used digital evolution to recreate the early stages in the evolution of natural cognition, including the ability to learn. Interestingly, I found cognition evolves in a predictable manner, with more complex abilities evolving in stages, by building upon previous simpler ones. I initially investigated the evolution of dynamic foraging behaviors among the first animals known to have a central nervous system, Ediacaran microbial mat miners. I then followed this up by evolving more complex forms of learning. I soon encountered practical limitations of the current methods, including exponential demand of computational resources and genetic representations that were not conducive to further scaling. This type of complexity barrier has been a recurrent issue in digital evolution. Nature, however, is not limited in the same ways; through evolution, it has created a language to express robust, modular, and flexible control systems of arbitrary complexity and apparently open-ended evolvability. The essential features of this language can be captured in a digital evolution platform. As an early demonstration of this, I evolved biologically plausible regulatory systems for virtual cyanobacteria. These systems regulate the cells' growth, photosynthesis and replication given the daily light cycle, the cell's energy reserves, and levels of stress. Although simple, this experimental system displays dynamics and decision-making mechanisms akin to biology, with promising potential for open-ended evolution of cognition towards general intelligence.
Show less

Title: Towards Accurate Ranging and Versatile Authentication for Smart Mobile Devices
Creator: Li, Lingkun
Date: 2022
Collection: Electronic Theses & Dissertations
Description: Internet of Things (IoTs) was rapidly developed during past years. Smart devices, such as smartphones, smartwatches, and smart assistants, which are equipped with smart chips as well as sensors, provide users with many easy used functions and lead them to a more convenient life. In this dissertation, we carefully studied the birefringence of the transparent tape, the nonlinear effects of the microphone, and the phase characteristic of the reflected ultrasound, and make use of such effects to...
Show moreInternet of Things (IoTs) was rapidly developed during past years. Smart devices, such as smartphones, smartwatches, and smart assistants, which are equipped with smart chips as well as sensors, provide users with many easy used functions and lead them to a more convenient life. In this dissertation, we carefully studied the birefringence of the transparent tape, the nonlinear effects of the microphone, and the phase characteristic of the reflected ultrasound, and make use of such effects to design three systems, RainbowLight, Patronus, and BreathPass, to provide users with accurate localization, privacy protection, and authentication, respectively.RainbowLight leverages observation direction-varied spectrum generated by a polarized light passing through a birefringence material, i.e., transparent tape, to provide localization service. We characterize the relationship between observe direction, light interference and the special spectrum, and using it to calculate the direction to a chip after taking a photo containing the chip. With multiple chips, RainbowLight designs a direction intersection based method to derive the location. In this dissertation, we build the theoretical basis of using polarized light and birefringence phenomenon to perform localization. Based on the theoretical model, we design and implement the RainbowLight on the mobile device, and evaluate the performance of the system. The evaluation results show that RainbowLight achieves 1.68 cm of the median error in the X-axis, 2 cm of the median error in the Y-axis, 5.74 cm of the median error in Z-axis, and 7.04 cm of the median error with the whole dimension.It is the first system that could only use the reflected lights in the space to perform visible light positioning. Patronus prevents unauthorized speech recording by leveraging the nonlinear effects of commercial off-the-shelf microphones. The inaudible ultrasound scramble interferes recording of unauthorized devices and can be canceled on authorized devices through an adaptive filter. In this dissertation, we carefully studied the nonlinear effects of ultrasound on commercial microphones. Based on the study, we proposed an optimized configuration to generate the scramble. It would provide privacy protection againist unauthorized recordings that does not disturb normal conversations. We designed, implemented a system including hardware and software components. Experiments results show that only 19.7% of words protected by Patronus' scramble can be recognized by unauthorized devices. Furthermore, authorized recordings have 1.6x higher perceptual evaluation of speech quality (PESQ) score and, on average, 50% lower speech recognition error rates than unauthorized recordings. BreathPass uses speakers to emit ultrasound signals. The signals are reflected off the chest wall and abdomen and then back to the microphone, which records the reflected signals. The system then extracts the fingerprints from the breathing pattern, and use these fingerprints to perform authentication. In this dissertation, we characterized the challenge of conducting authentication with the breathing pattern. After addressing these challenges, we designed such a system and implemented a proof-of-concept application on Android platform.We also conducted comprehensive experiments to evaluate the performance under different scenarios. BreathPass achieves an overall accuracy of 83%, a true positive rate of 73%, and a false positive rate of 5%, according to performance evaluation results. In general, this dissertation provides an enhanced ranging and versatile authentication systems of Internet of Things.
Show less

Title: Investigating the Role of Sensor Based Technologies to Support Domestic Activities in Sub-Saharan Africa
Creator: Chidziwisano, George Hope
Date: 2022
Collection: Electronic Theses & Dissertations
Description: In sub-Saharan Africa (SSA), homes face various challenges including insecurity, unreliable power supply, and extreme weather conditions. While the use of sensor-based technologies is increasing in industrialized countries, it is unclear how they can be used to support domestic activities in SSA. The availability of low-cost sensors and the widespread adoption of mobile phones presents an opportunity to collect real-time data and utilize proactive methods to monitor these challenges. This...
Show moreIn sub-Saharan Africa (SSA), homes face various challenges including insecurity, unreliable power supply, and extreme weather conditions. While the use of sensor-based technologies is increasing in industrialized countries, it is unclear how they can be used to support domestic activities in SSA. The availability of low-cost sensors and the widespread adoption of mobile phones presents an opportunity to collect real-time data and utilize proactive methods to monitor these challenges. This dissertation presents three studies that build upon each other to explore the role of sensor-based technologies in SSA. I used a technology probes method to develop three sensor-based systems that support domestic security (M-Kulinda), power blackout monitoring (GridAlert) and poultry farming (NkhukuApp). I deployed M-Kulinda in 20 Kenyan homes, GridAlert in 18 Kenyan homes, and NkhukuProbe in 15 Malawian home-based chicken coops for one month. I used interview, observation, diary, and data logging methods to understand participants’ experiences using the probes. Findings from these studies suggest that people in Kenya and Malawi want to incorporate sensor-based technologies into their everyday activities, and they quickly find unexpected ways to use them. Participants’ interactions with the probes prompted detailed reflections about how they would integrate sensor-based technologies in their homes (e.g., monitoring non-digital tools). These reflections are useful for motivating new design concepts in HCI. I use these findings to motivate a discussion about unexplored areas that could benefit from sensor-based technologies. Further, I discuss recommendations for designing sensor-based technologies that support activities in some Kenyan and Malawian homes. This research contributes to HCI by providing design implications for sensor-based applications in Kenyan and Malawian homes, employing a technology probes method in a non-traditional context, and developing prototypes of three novel systems.
Show less

Title: Discrete de Rham-Hodge Theory
Creator: Zhao, Rundong
Date: 2020
Collection: Electronic Theses & Dissertations
Description: We present a systematic treatment to 3D shape analysis based on the well-established de Rham-Hodge theory in differential geometry and topology. The computational tools we developed are widely applicable to research areas such as computer graphics, computer vision, and computational biology. We extensively tested it in the context of 3D structure analysis of biological macromolecules to demonstrate the efficacy and efficiency of our method in potential applications. Our contributions are...
Show moreWe present a systematic treatment to 3D shape analysis based on the well-established de Rham-Hodge theory in differential geometry and topology. The computational tools we developed are widely applicable to research areas such as computer graphics, computer vision, and computational biology. We extensively tested it in the context of 3D structure analysis of biological macromolecules to demonstrate the efficacy and efficiency of our method in potential applications. Our contributions are summarized in the following aspects. First, we present a compendium of discrete Hodge decompositions of vector fields, which provides the primary building block of the de Rham-Hodge theory for computations performed on the commonly used tetrahedral meshes embedded in the 3D Euclidean space. Second, we present a real-world application of the above computational tool to 3D shape analysis on biological macromolecules. Finally, we extend the above method to an evolutionary de Rham-Hodge method to provide a unified paradigm for the multiscale geometric and topological analysis of evolving manifolds constructed from a filtration, which induces a family of evolutionary de Rham complexes. Our work on the decomposition of vector fields, spectral shape analysis on static shapes, and evolving shapes has already shown its effectiveness in biomolecular applications and will lead to a rich set of features for machine learning-based shape analysis currently under development.
Show less

Title: SIGN LANGUAGE RECOGNIZER FRAMEWORK BASED ON DEEP LEARNING ALGORITHMS
Creator: Akandeh, Atra
Date: 2021
Collection: Electronic Theses & Dissertations
Description: According to the World Health Organization (WHO, 2017), 5% of the world’s population have hearing loss. Most people with hearing disabilities communicate via sign language, which hearing people find extremely difficult to understand. To facilitate communication of deaf and hard of hearing people, developing an efficient communication system is a necessity. There are many challenges associated with the Sign Language Recognition (SLR) task, namely, lighting conditions, complex background,...
Show moreAccording to the World Health Organization (WHO, 2017), 5% of the world’s population have hearing loss. Most people with hearing disabilities communicate via sign language, which hearing people find extremely difficult to understand. To facilitate communication of deaf and hard of hearing people, developing an efficient communication system is a necessity. There are many challenges associated with the Sign Language Recognition (SLR) task, namely, lighting conditions, complex background, signee body postures, camera position, occlusion, complexity and large variations in hand posture, no word alignment, coarticulation, etc.Sign Language Recognition has been an active domain of research since the early 90s. However, due to computational resources and sensing technology constraints, limited advancement has been achieved over the years. Existing sign language translation systems mostly can translate a single sign at a time, which makes them less effective in daily-life interaction. This work develops a novel sign language recognition framework using deep neural networks, which directly maps videos of sign language sentences to sequences of gloss labels by emphasizing critical characteristics of the signs and injecting domain-specific expert knowledge into the system. The proposed model also allows for combining data from variant sources and hence combating limited data resources in the SLR field.
Show less

Title: Network analysis with negative links
Creator: Derr, Tyler Scott
Date: 2020
Collection: Electronic Theses & Dissertations
Description: As we rapidly continue into the information age, the rate at which data is produced has created an unprecedented demand for novel methods to effectively extract insightful patterns. We can then seek to understand the past, make predictions about the future, and ultimately take actionable steps towards improving our society. Thus, due to the fact that much of today's big data can be represented as graphs, emphasis is being taken to harness the natural structure of data through network analysis...
Show moreAs we rapidly continue into the information age, the rate at which data is produced has created an unprecedented demand for novel methods to effectively extract insightful patterns. We can then seek to understand the past, make predictions about the future, and ultimately take actionable steps towards improving our society. Thus, due to the fact that much of today's big data can be represented as graphs, emphasis is being taken to harness the natural structure of data through network analysis. Traditionally, network analysis has focused on networks having only positive links, or unsigned networks. However, in many real-world systems, relations between nodes in a graph can be both positive and negative, or signed networks. For example, in online social media, users not only have positive links such as friends, followers, and those they trust, but also can establish negative links to those they distrust, towards their foes, or block and unfriend users.Thus, although signed networks are ubiquitous due to their ability to represent negative links in addition to positive links, they have been significantly under explored. In addition, due to the rise in popularity of today's social media and increased polarization online, this has led to both an increased attention and demand for advanced methods to perform the typical network analysis tasks when also taking into consideration negative links. More specifically, there is a need for methods that can measure, model, mine, and apply signed networks that harness both these positive and negative relations. However, this raises novel challenges, as the properties and principles of negative links are not necessarily the same as positive links, and furthermore the social theories that have been used in unsigned networks might not apply with the inclusion of negative links.The chief objective of this dissertation is to first analyze the distinct properties negative links have as compared to positive links and towards improving network analysis with negative links by researching the utility and how to harness social theories that have been established in a holistic view of networks containing both positive and negative links. We discover that simply extending unsigned network analysis is typically not sufficient and that although the existence of negative links introduces numerous challenges, they also provide unprecedented opportunities for advancing the frontier of the network analysis domain. In particular, we develop advanced methods in signed networks for measuring node relevance and centrality (i.e., signed network measuring), present the first generative signed network model and extend/analyze balance theory to signed bipartite networks (i.e., signed network modeling), construct the first signed graph convolutional network which learns node representations that can achieve state-of-the-art prediction performance and then furthermore introduce the novel idea of transformation-based network embedding (i.e., signed network mining), and apply signed networks by creating a framework that can infer both link and interaction polarity levels in online social media and constructing an advanced comprehensive congressional vote prediction framework built around harnessing signed networks.
Show less

Title: MICROBLOG GUIDED CRYPTOCURRENCY TRADING AND FRAMING ANALYSIS
Creator: Pawlicka Maule, Anna Paula
Date: 2020
Collection: Electronic Theses & Dissertations
Description: With 56 million people actively trading and investing in cryptocurrency online and globally, there is an increasing need for an automatic social media analysis tool to help understand trading discourse and behavior. Previous works have shown the usefulness of modeling microblog discourse for the prediction of trading stocks and their price fluctuations, as well as content framing. In this work, I present a natural language modeling pipeline that leverages language and social network behaviors...
Show moreWith 56 million people actively trading and investing in cryptocurrency online and globally, there is an increasing need for an automatic social media analysis tool to help understand trading discourse and behavior. Previous works have shown the usefulness of modeling microblog discourse for the prediction of trading stocks and their price fluctuations, as well as content framing. In this work, I present a natural language modeling pipeline that leverages language and social network behaviors for the prediction of cryptocurrency day trading actions and their associated framing patterns. Specifically, I present two modeling approaches. The first determines if the tweets of a 24-hour period can be used to guide day trading behavior, specifically if a cryptocurrency investor should buy, sell, or hold their cryptocurrencies in order to make a trading profit. The second is an unsupervised deep clustering approach to automatically detect framing patterns. My contributions include the modeling pipeline for this novel task, a new dataset of cryptocurrency-related tweets from influential accounts, and a transaction volume dataset. The experiments executed show that this weakly-supervised trading pipeline achieves an 88.78% accuracy for day trading behavior predictions and reveals framing fluctuations prior to and during the COVID-19 pandemic that could be used to guide investment actions.
Show less

MSU Libraries

Digital Repository

Enabled Filters

Pages

Pages

MSU Libraries

Digital Repository

You are here

Search results

Pages

Pages