In the world of medical informatics, biomarkers play a pivotal role in determining the physical state of human beings, distinguishing the pathologic from the clinically normal. In recent years, behavioral markers, due to their availability and low cost, have attracted a lot of attention as a potential supplement to biomarkers. “Language markers” such as spoken words and lexical preference have been shown to be both cost-effective as well as predictive of complex diseases such as mild... Show moreIn the world of medical informatics, biomarkers play a pivotal role in determining the physical state of human beings, distinguishing the pathologic from the clinically normal. In recent years, behavioral markers, due to their availability and low cost, have attracted a lot of attention as a potential supplement to biomarkers. “Language markers” such as spoken words and lexical preference have been shown to be both cost-effective as well as predictive of complex diseases such as mild cognitive impairment (MCI).However, language markers, although universal, do not possess many of the favorable properties that characterize traditional biomakers. For example, different people may exhibit similar use of language under certain conversational contexts (non-unique), and a person's lexical preferences may change over time (non-stationary). As a result, it is unclear whether any set of language markers can be measured in a consistent manner. My thesis projects provide solutions to some of the limitations of language markers: (1) We formalize the problem of learning a dialog policy to measure language markers as an optimization problem which we call persona authentication. We provide a learning algorithm for finding such a dialog policy that can generalize to unseen personalities. (2) We apply our dialog policy framework on real-world data for MCI prediction and show that the proposed pipeline improves prediction against supervised learning baselines. (3) To address non-stationarity, we introduce an effective way to do temporally-dependent and non-i.i.d. feature selection through an adversarial learning framework which we call precision sensing. (4) Finally, on the prediction side, we propose a method for improving the sample efficiency of classifiers by retaining privileged information (auxiliary features available only at training time). Show less
